14 Results for "

FN14

" in MedChemExpress (MCE) Product Catalog:
Products (14)

14 Results for "FN14" in MCE Product Catalog:

5
5 Cited Publications
Art. -Nr.: HY-122575
CAS. Nr.: 4431-00-9
Reinheit:  ≥92.0%
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively . Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase . Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis . Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway . Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM . Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 µM .
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1
1 Cited Publications
Art. -Nr.: HY-P72434
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF12A; Fibroblast growth factor-inducible immediate-early response protein 14; FN14; CD266 antigen and tweak-receptor
Species:  
Source:  
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Art. -Nr.: HY-P99361
CAS. Nr.: 1062149-33-0
Synonyms: PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)

Target:  

TNF Receptor

Forschungsgebiete:  

Cancer

Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .
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Art. -Nr.: HY-113763
CAS. Nr.: 951612-19-4
Target:  

TNF Receptor

Forschungsgebiete:  

Others

L524-0366 is a specific, dose-dependent TWEAK-Fn14 inhibitor. L524-0366 specifically binds to the Fn14 surface with a KD of 7.12 μM, competitively inhibiting the binding of Fn14 to TWEAK (inhibition rate reaching 16%). L524-0366 inhibits TWEAK-induced glioma cell migration without potential cytotoxic effects .
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Art. -Nr.: HY-P991433

Target:  

TNF Receptor

Forschungsgebiete:  

Cancer

BIIB036 is a human IgG1 monoclonal antibody (mAb) targeting TNFRSF12A/Fn14. BIIB036 inhibits the growth of patient-derived primary colorectal tumors in SCID mice .
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Art. -Nr.: HY-RS14803
Forschungsgebiete:  

Others

TNFRSF12A Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF12A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Art. -Nr.: HY-P72435
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF12A; Fibroblast growth factor-inducible immediate-early response protein 14; FN14; CD266 antigen and tweak-receptor
Species:  
Source:  
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Art. -Nr.: HY-P71909
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD 266; CD266; CD266 antigen; FGF inducible 14; FGF-inducible 14; Fibroblast growth factor inducible immediate early response protein 14; Fibroblast growth factor-inducible immediate-early response protein 14; FN 14; FN14; TNFRSF 12A; TNFRSF12A; TNR12_HUMAN; Tumor necrosis factor receptor superfamily member 12A; TWEAK R; Tweak receptor; Tweak-receptor; TweakR
Species:  
Source:  
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Art. -Nr.: HY-P810450
Synonyms: FN14, TNFRSF 12A, Tweak receptor, TweakR,

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IF-Tissue, IP

Reactivity:  

Human, Mouse, Rat

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Art. -Nr.: HY-P82931
Synonyms: CD266 antigen; FGF inducible 14; Fibroblast growth factor inducible immediate early response protein 14; FN14; TNFRSF 12A; Tweak receptor; TweakR

Host:  

Rabbit

Application:  

WB, IHC-P, IP

Reactivity:  

Human, Mouse, Rat

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Art. -Nr.: HY-RS17480
Forschungsgebiete:  

Others

Tnfrsf12a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf12a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Art. -Nr.: HY-P82931A
Synonyms: CD266 antigen; FGF inducible 14; Fibroblast growth factor inducible immediate early response protein 14; FN14; TNFRSF 12A; Tweak receptor; TweakR

Host:  

Rabbit

Application:  

WB, IHC-P, IP

Reactivity:  

Human, Mouse, Rat

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Art. -Nr.: HY-RS23938
Forschungsgebiete:  

Others

Tnfrsf12a Rat Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf12a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Art. -Nr.: HY-P992321

Target:  

TNF Receptor NF-κB STAT

Forschungsgebiete:  

Cancer

BAY-356, a potent TWEAK receptor agonist, is an aglycosylated anti-TWEAK receptor antibody. BAY-356 triggers TWEAKR hyperactivation, activates NFκB and STAT1 pathways, and undergoes TWEAKR-dependent internalization. BAY-356 can be used for the research of colorectal cancer, bladder cancer, non-small cell lung cancer and pancreatic cancer[1][2].
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