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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
Fe(II)
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "Fe(II)" in MCE Product Catalog:
1
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(E)-4-Oxo-2-nonenal (4-ONE) is one of the major hemolytic decomposition products of lipid hydroperoxides. (E)-4-Oxo-2-nonenal is a major product of the FeII-mediated breakdown of lipid hydroperoxides. (E)-4-Oxo-2-nonenal is a potent transient receptor potential ankyrin 1 (TRPA1) agonist .
Cat. No.: HY-W345885
CAS No.: 87-73-0
Target:
degradation of organic contaminants .
Cat. No.: HY-D2339
CAS No.: 2897614-59-2
Cat. No.: HY-120420
CAS No.: 167695-87-6
Research Areas:
N4Py is a bleomycin-mimetic pentadentate ligand that targets intracellular FeII and reversibly chelates a variety of transition metals. N4Py chelates induce apoptosis through two pathways: DNA cleavage via ROS generation and XIAP downregulation via ZnII chelation, with only FeII/FeIII-N4Py exhibiting potent DNA cleavage activity. The folate conjugate of N4Py targets folate receptors, can be intracellularly cleaved, and selectively kills FR-positive cancer cells. N4Py can be used in research on various cancers including nasopharyngeal epidermoid carcinoma, ovarian cancer, and mammary adenocarcinoma .
Cat. No.: HY-W739372
CAS No.: 25704-18-1
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Poly (sodium 4-styrenesulfonate) is an anionic cation-exchange polyelectrolyte and metal ion binding/retention agent. It selectively retains Cr III and Fe II under pH 1 conditions, and its retention effect on all tested metal ions is enhanced under higher pH conditions. Poly (sodium 4-styrenesulfonate) inhibits nanosheet aggregation through edge-face interactions between aromatic rings and the graphite surface, thereby stabilizing the dispersion of reduced graphene oxide nanosheets. When incorporated into the mixed Nafion coating of bismuth film electrodes, Poly (sodium 4-styrenesulfonate) improves the reproducibility, stability, sensitivity, and anti-fouling capability for trace metal detection .
Cat. No.: HY-175698
Research Areas:
Ferroptosis inducer-9 is a ferroptosis inducer and colchicine site tubulin polymerization inhibitor. Ferroptosis inducer-9 inhibits MCF-7 cell growth with an IC50 of 14 nM and inhibits [ 3H]colchicine binding. Ferroptosis inducer-9 reduces expression of GPX4 and FTH, increases COX2 and ACSL4, lowers GSH, NADP+, and NADPH levels, increases LPO, MDA, and Fe(II) levels, and decreases SOD concentrations. Ferroptosis inducer-9 demonstrates significant anti-tumor efficacy in HCT116 CRC xenograft model. Ferroptosis inducer-9 can be used for the study of triple negative breast cancer (TNBC) and colorectal cancer (CRC) .
Cat. No.: HY-157917
Cat. No.: HY-148340
CAS No.: 185675-92-7
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24RBPyBC is a dinucleating macrocyclic ligand, it contains phenolate pyridine, bipyridine, and amino groups form dinuclear Fe(II) and Fe(III) complexes .
Cat. No.: HY-W130303
CAS No.: 625-77-4
Synonyms: N-Acetylacetamide; Diacetylamine; Diacetimide
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Diacetamide is shown to form a variety of new compounds with a general formula [M(C4H7O2N) 3](ClO4)2, where M = Mn(II), Fe(II), Co(II), Ni(II), or Zn(II). Diacetamide ligands can be used in uranium extraction from wastewater. Diacetamide can be used for amidase synthesis .
Cat. No.: HY-E70583
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Recombinant Ten-Eleven Translocase is a recombinant Fe(II)- and α-ketoglutarate-dependent dioxygenase. Recombinant Ten-Eleven Translocase converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), and then to 5-formylcytosine (5fC) and 5-carboxycytosine (5caC) through a series of oxidation reactions. Then, 5caC is further converted into uracil (U) through the action of a conversion agent or enzyme, and uracil (U) is converted into thymine (T) through PCR, thereby achieving single-base resolution and high-accuracy identification of DNA methylation sites .
Cat. No.: HY-138185
CAS No.: 158792-24-6
Synonyms: SF 2738A
Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs=6.25 and 100 μg/mL) and fungi (MICs=12.5-100 μg/mL). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s=0.3, 0.6, and 0.3 μM, respectively) and NIH373 fibroblasts (IC50=56.6 μM) but not MDA-MD-231 breast cancer cells (IC50=>100 μM). Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions.3 Collismycin A (1 μM) prevents apoptosis in the brain region of zebrafish larvae in a model of neuronal cell death induced by all-trans retinoic acid.
Cat. No.: HY-E71386
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1-Deoxypentalenic acid 11β-hydroxylase (EC 1.14.11.35) requires Fe(II) and ascorbate.
Cat. No.: HY-E70905
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Research Areas:
Taurine Dioxygenase, E. coli (EC 1.14.11.17) is a Fe(II) and α-ketoglutaric aciddependent dioxygenase, which enables E.coli to use taurine as a sulfur source. Taurine Dioxygenase catalyzes the conversion of the amino acid taurine (2-aminoethane-1-sulfonic acid) to sulfite and aminoacetaldehyde.
Cat. No.: HY-E71859
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4-Hydroxysphinganine ceramide fatty acyl 2-hydroxylase (EC 1.14.18.6) is an oxidoreductase that can catalyze multiple reactions, including reaction 1: convert an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine, 2 Fe(II)- [cytochrome b5], O2 and 2 H + into an N-(2R-hydroxyacyl)- 4R-hydroxysphinganine, 2 Fe(III)-[cytochrome b5] and H2O; reaction 2: convert an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base, 2 Fe(II)-[cytochrome b5], O2 and 2 H + into an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base, 2 Fe(III)-[cytochrome b5] and H2O.
Cat. No.: HY-E71559
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2-Hydroxyethylphosphonate dioxygenase (EC 1.13.11.72) requires non-heme-Fe(II).
Cat. No.: HY-149151
CAS No.: 20988-30-1
Category:
Cat. No.: HY-E71279
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β-Carotene 3-hydroxylase (EC 1.14.13.129) requires ferredoxin and Fe (II) . Also acts on other carotenoids with a β-end group.
Cat. No.: HY-W989128
CAS No.: 686723-15-9
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Ethyl 8-hydroxy-α-(2-propynylamino) is a bifunctional iron chelator that inhibits lipid peroxidation (IC50 = 15 μM). Ethyl 8-hydroxy-α-(2-propynylamino) chelates Fe (II) and Fe (III) metal ions, and inhibits iron/ascorbic acid-induced mitochondrial membrane lipid peroxidation. Ethyl 8-hydroxy-α-(2-propynylamino) can be used in the research of oxidative stress and neurodegenerative diseases .
Cat. No.: HY-W1059094
CAS No.: 5998-89-0
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2-(Pyridin-2-yl) oxazole is a bis-heteroaryl compound that serves as a pharmaceutical intermediate for synthesizing active compounds, such as CP4H1 inhibitors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
