167695-87-6
Chemical Structure
N4Py
- CAS No.: 167695-87-6
- Formula:C23H21N5
- Molecular Weight:367.45
IUPAC Name: 1,1-di(pyridin-2-yl)-N,N-bis(pyridin-2-ylmethyl)methanamine
InChIKey: PRICLFAUAJHZLI-UHFFFAOYSA-N
SMILES: C1(C(C2=CC=CC=N2)N(CC3=CC=CC=N3)CC4=NC=CC=C4)=NC=CC=C1
Biological Activity: N4Py is a bleomycin-mimetic pentadentate ligand that targets intracellular FeII and reversibly chelates a variety of transition metals. N4Py chelates induce apoptosis through two pathways: DNA cleavage via ROS generation and XIAP downregulation via ZnII chelation, with only FeII/FeIII-N4Py exhibiting potent DNA cleavage activity. The folate conjugate of N4Py targets folate receptors, can be intracellularly cleaved, and selectively kills FR-positive cancer cells. N4Py can be used in research on various cancers including nasopharyngeal epidermoid carcinoma, ovarian cancer, and mammary adenocarcinoma[1][2].
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N4Py | N4Py is a bleomycin-mimetic pentadentate ligand that targets intracellular FeII and reversibly chelates a variety of transition metals. N4Py chelates induce apoptosis through two pathways: DNA cleavage via ROS generation and XIAP downregulation via ZnII chelation, with only FeII/FeIII-N4Py exhibiting potent DNA cleavage activity. The folate conjugate of N4Py targets folate receptors, can be intracellularly cleaved, and selectively kills FR-positive cancer cells. N4Py can be used in research on various cancers including nasopharyngeal epidermoid carcinoma, ovarian cancer, and mammary adenocarcinoma. | |||||||||||||||||||||
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- [1]. Geersing A, et al. Importance of Metal-Ion Exchange for the Biological Activity of Coordination Complexes of the Biomimetic Ligand N4Py. Inorganic chemistry. 2018 Jul 02;57(13):7748-7756. [Content Brief]
- [2]. Geersing A. Redox-active N4Py-metal complexes in human cell cultures. Groningen: Rijksuniversiteit Groningen, 2017. ISBN 978-90-367-9760-3.
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