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Fmoc protecting groups

" in MedChemExpress (MCE) Product Catalog:

111

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19

Biochemical Assay Reagents

53

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7

Isotope-Labeled Compounds

5

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y1636

    Amino Acid Derivatives Drug Intermediate Metabolic Disease
    Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .
    Fmoc-Arg(Pbf)-OH
  • HY-Y1169

    4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate; Fmoc-L-Asp(OtBu)-OH

    Amino Acid Derivatives Others
    Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is an aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .
    Fmoc-Asp(OtBu)-OH
  • HY-W010712
    Fmoc-His(Trt)-OH
    1 Publications Verification

    Amino Acid Derivatives Others
    Fmoc-His(Trt)-OH is a histidine derivative with a trityl (Trt) group protecting the His side chain. Fmoc-His(Trt)-OH also has an Fmoc group protecting the α-NH2 group. Fmoc-His(Trt)-OH can be used in solid-phase peptide synthesis to prevent racemization and byproduct formation. Fmoc-His(Trt)-OH acts as a protected histidine precursor in solid-phase peptide synthesis (SPPS), participating in peptide chain construction through amide bond formation. Fmoc-His(Trt)-OH can be precisely incorporated into the target peptide sequence, ensuring correct peptide chain synthesis and reducing impurity formation. Fmoc-His(Trt)-OH is mainly used in the solid-phase synthesis research of pharmaceutical peptides and bioactive peptides, and is particularly suitable for the preparation of peptide drugs requiring precise control of histidine configuration .
    Fmoc-His(Trt)-OH
  • HY-79647

    N-(Fmoc-oxy)succinimide

    Biochemical Assay Reagents Others
    Fmoc-OSu (N-(Fmoc-oxy)succinimide) is an acylating agent that targets amino groups (-NH2). It can selectively protect the amino groups of amino acids by covalently binding with primary or secondary amines through nucleophilic substitution reactions. Fmoc-OSu forms a stable amide bond with the amino group to avoid side reactions of the amino group in peptide synthesis. It can also be used as a fluorescent labeling reagent to react with glycosylamines for efficient labeling of N-sugar chains. Fmoc-OSu can be used as an Fmoc protection strategy in peptide synthesis, and as a fluorescent labeling and analysis method for N-sugar chains .
    Fmoc-OSu
  • HY-W013081
    Fmoc-Gln(Trt)-OH
    1 Publications Verification

    Amino Acid Derivatives Others
    Fmoc-Gln(Trt)-OH is a glutamine derivative containing amine protecting group Fmoc. Fmoc-Gln(Trt)-OH can be used in solid-phase peptide synthesis .
    Fmoc-Gln(Trt)-OH
  • HY-W048739

    Amino Acid Derivatives Others
    Fmoc-α-Me-Leu-OH is a leucine derivative with an Fmoc protecting group, which can be used to synthesize peptides with oxytocin receptor agonist activity .
    Fmoc-α-Me-Leu-OH
  • HY-W048688

    Amino Acid Derivatives Others
    Fmoc-Trp(Me)-OH is an amino acid derivative. Fmoc-Trp(Me)-OH is formed by introducing a methyl group onto the nitrogen atom (N-1 position) of the indole ring of tryptophan (Trp) and protecting the amino group with Fmoc (9-fluorenylmethyloxycarbonyl). Fmoc-Trp(Me)-OH can be used in the synthesis of proteins or peptides .
    Fmoc-Trp(Me)-OH
  • HY-78933

    Microtubule/Tubulin ADC Payload Cancer
    Fmoc-MMAE is a protective group-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Fmoc-MMAE can be used in the synthesis of ADC .
    Fmoc-MMAE
  • HY-W008876

    Amino Acid Derivatives Drug Intermediate Biochemical Assay Reagents Others
    Fmoc-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize the inhibitory cystine knot (ICK) peptide ProTx-II .
    Fmoc-Pen(Trt)-OH
  • HY-137002

    Amino Acid Derivatives Biochemical Assay Reagents Others
    Fmoc-N-Me-Arg(Pbf)-OH is an amino acid derivative containing a guanidinium protecting group on the arginine side chain. Fmoc-N-Me-Arg(Pbf)-OH is used in the synthesis of neurotensin-derived NTS1 ligands for PET imaging .
    Fmoc-N-Me-Arg(Pbf)-OH
  • HY-W010922

    Amino Acid Derivatives Others
    Fmoc-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bicyclic peptide tachykinin NK2 antagonists .
    Fmoc-Dap(Boc)-OH
  • HY-W007056

    Amino Acid Derivatives Biochemical Assay Reagents Drug Intermediate Infection
    Fmoc-N-me-Trp(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptide antibiotics with antibacterial activity against Pseudomonas aeruginosa .
    Fmoc-N-me-Trp(Boc)-OH
  • HY-W008064

    Fmoc-L-Citrulline

    Amino Acid Derivatives Cancer
    Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif .
    Fmoc-Cit-OH
  • HY-W425682

    Drug Intermediate Others
    Fmoc-L-Penicillamine is formed by the connection of the Fmoc protecting group and L-Penicillamine through a specific chemical bond. Fmoc-L-Penicillamine plays an important role in organic synthesis, especially in the field of peptide synthesis .
    Fmoc-L-Penicillamine
  • HY-W009118

    Amino Acid Derivatives Others
    Fmoc-5-Ava-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize fatty acid-based dimeric peptides with PSD-95 inhibitory activity .
    Fmoc-5-Ava-OH
  • HY-W019032

    Amino Acid Derivatives Others
    Fmoc-D-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with antibacterial activity .
    Fmoc-D-Dab(Boc)-OH
  • HY-W013154

    Amino Acid Derivatives Others
    Fmoc-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as the biotinylated derivative of the opioid receptor antagonist TIPP .
    Fmoc-Tic-OH
  • HY-79255

    ADC Payload Microtubule/Tubulin Cancer
    Fmoc-MMAF-OMe is an anticancer agent and tubulin polymerization inhibitor with an Fmoc protecting group. The active ingredient of Fmoc-MMAF-OMe, MMAF (HY-15579), is the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs) .
    Fmoc-MMAF-OMe
  • HY-W015987

    Fmoc-NH2

    Biochemical Assay Reagents Others
    9-Fluorenylmethyl carbamate (Fmoc-NH2) is an amide compound with an Fmoc protecting group, which can be used as a photobase initiator to prepare organosilane-based proton exchange membranes .
    9-Fluorenylmethyl carbamate
  • HY-W048697

    Amino Acid Derivatives Others
    Fmoc-D-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize analogs of cyclic lanthionine enkephalin, a δ-opioid receptor selective ligand .
    Fmoc-D-Pen(Trt)-OH
  • HY-W097128

    PROTAC Linkers Cancer
    Fmoc-12-aminododecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
    Fmoc-12-aminododecanoic acid
  • HY-W008024

    Amino Acid Derivatives Others
    Fmoc-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize somatostatin analogs that inhibit neointima formation induced by balloon injury in rats without altering growth hormone release. Fmoc-Dab(Boc)-OH can be used for the synthesis of peptides .
    Fmoc-Dab(Boc)-OH
  • HY-164732

    Amino Acid Derivatives Biochemical Assay Reagents Others
    Fmoc-Lys (DOTA)-OH is an Fmoc-protected Lysine derivative with metal-chelating properties, containing the macrocyclic chelator DOTA. Fmoc-Lys (DOTA)-OH undergoes metallation with Tb or Lu. Fmoc-Lys (DOTA)-OH utilizes metal coordination to protect the carboxyl groups of DOTA. Fmoc-Lys (DOTA)-OH can be used in solid-phase peptide synthesis research .
    Fmoc-Lys(DOTA)-OH
  • HY-W048722

    Fmoc-D-2-Thienylalanine

    Amino Acid Derivatives Others
    Fmoc-D-Thi-OH (Fmoc-D-2-Thienylalanine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize AS-Z-P with thrombin inhibitory activity .
    Fmoc-D-Thi-OH
  • HY-W009056

    PROTAC Linkers Cancer
    Fmoc-7-amino-heptanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. Fmoc-7-amino-heptanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
    Fmoc-7-amino-heptanoic acid
  • HY-W046355

    Radionuclide-Drug Conjugates (RDCs) Amino Acid Derivatives Others
    Fmoc-D-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as DOTA-modified peptides and their metal chelates with cancer diagnostic effects .
    Fmoc-D-Dap(Boc)-OH
  • HY-W041989

    Amino Acid Derivatives Drug Intermediate Biochemical Assay Reagents Others
    Fmoc-Oic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as [desArg 10]HOE 140, which has bradykinin B1 antagonist activity .
    Fmoc-Oic-OH
  • HY-W048730

    Amino Acid Derivatives Others
    Fmoc-Phe(4-tBu)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize rOicPaPhe(p-Me)-NH(2) with platelet aggregation activation inhibitory activity .
    Fmoc-Phe(4-tBu)-OH
  • HY-W009030

    PROTAC Linkers Cancer
    N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
    N-Fmoc-8-aminooctanoic acid
  • HY-Y1636S

    Isotope-Labeled Compounds Amino Acid Derivatives Drug Intermediate Metabolic Disease
    Fmoc-Arg(Pbf)-OH- 13C6, 15N4 is the 13C-labeled and 15N-labeled Fmoc-Arg(Pbf)-OH (HY-Y1636). Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .
    Fmoc-Arg(Pbf)-OH-13C6,15N4
  • HY-151748

    ADC Linker Others
    N3-L-Orn(Fmoc)-OH is a Fmoc-protected ornithine derivative, can be used as a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    N3-L-Orn(Fmoc)-OH
  • HY-W419374

    Amino Acid Derivatives Others
    ivDde-Lys(Fmoc)-OH is a derivative of amino acid with protecting groups. ivDde-Lys(Fmoc)-OH can be used for peptide synthesis .
    ivDde-Lys(Fmoc)-OH
  • HY-W101305

    Amino Acid Derivatives Others
    Fmoc-Pen(Acm)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize chemically modified cyclic peptides containing cell adhesion recognition (CAR) sequences .
    Fmoc-Pen(Acm)-OH
  • HY-PS0011

    Drug Intermediate Others
    Fmoc-Gly-Wang resin is a resin containing a glycine protecting group and can be used for the synthesis of peptides .
    Fmoc-Gly-Wang resin
  • HY-W047799

    Amino Acid Derivatives Others
    Fmoc-Phe(4-CONH2)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a small-sized HTLV-I protease inhibitor with hydrophilicity .
    Boc-Dap(Boc)-OH
  • HY-W013081S

    Isotope-Labeled Compounds Amino Acid Derivatives Others
    Fmoc-Gln(Trt)-OH- 13C5, 15N2 is the 13C-labeled and 15N-labeled Fmoc-Gln(Trt)-OH (HY-W013081). Fmoc-Gln(Trt)-OH is a glutamine derivative containing amine protecting group Fmoc. Fmoc-Gln(Trt)-OH can be used in solid-phase peptide synthesis .
    Fmoc-Gln(Trt)-OH-13C5,15N2
  • HY-W088805

    Fmoc-3-carboxypiperidine

    Amino Acid Derivatives Others
    Fmoc-NIP-OH (Fmoc-3-carboxypiperidine) is a Fmoc-protected amino acid derivative commonly used in peptide synthesis .
    Fmoc-NIP-OH
  • HY-W097054

    Amino Acid Derivatives Others
    Fmoc-L-cysteic acid is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize triarylsulfonium compounds for radiolabeling of peptides .
    Fmoc-L-cysteic acid
  • HY-W141765

    Biochemical Assay Reagents Others
    Fmoc-Cit-PAB-OH is a peptide linker containing an Fmoc-protected amine and citrulline residue. The Fmoc group can be deprotected under basic conditions to obtain the free amine, which can be used for further conjugations.
    Fmoc-Cit-PAB-OH
  • HY-W048718

    Fmoc-D-α-t-butylglycine

    Amino Acid Derivatives Others
    Fmoc-D-Tle-OH (Fmoc-D-α-t-butylglycine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize chelating agents that can form a single stereoisomer-enriched form after coordination with metal centers .
    Fmoc-D-Tle-OH
  • HY-W013153

    Amino Acid Derivatives Others
    Fmoc-D-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as [desArg 10]HOE 140, which has bradykinin B1 antagonist activity .
    Fmoc-D-Tic-OH
  • HY-151640

    ADC Linker Others
    Fmoc-DAP-N3 is a click chemistry reagent containing an azide group. Fmoc-DAP-N3 is a short, linear spacer molecule with Fmoc protected amino function. Fmoc-DAP-N3 can be used in click conjugation and amid bond formation either with small molecules or for bioconjugation with proteins and antibodies . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Fmoc-DAP-N3
  • HY-174931

    Biochemical Assay Reagents Others
    HO-PEG1000-NH-Fmoc is a PEG derivative with an Fmoc protecting group and a hydroxyl (OH) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction.
    HO-PEG1000-NH-Fmoc
  • HY-174949B

    Fmoc-NH-PEG3400-Thiol

    Biochemical Assay Reagents Others
    FMOC-NH-PEG3400-SH (FMOC-NH-PEG3400-Thiol) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
    FMOC-NH-PEG3400-SH
  • HY-174961C

    Fmoc-NH-PEG5000-Mal

    Biochemical Assay Reagents Others
    Fmoc-PEG5000-Maleimide (Fmoc-NH-PEG5000-Mal) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
    Fmoc-PEG5000-Maleimide
  • HY-174961

    Fmoc-NH-PEG1000-Mal

    Biochemical Assay Reagents Others
    Fmoc-PEG1000-Maleimide (Fmoc-NH-PEG1000-Mal) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
    Fmoc-PEG1000-Maleimide
  • HY-174896A

    Biochemical Assay Reagents Others
    DSPE-PEG2000-Fmoc is a lipid-containing PEG derivative that can be used to form micelles as nanoparticles for drug delivery . Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
    DSPE-PEG2000-Fmoc
  • HY-43781

    Biochemical Assay Reagents Others
    Fmoc-Lys(Boc)-PAB-OH is a peptide linker containing an Fmoc-protected amine and a Boc-protected lysine residue. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations.
    Fmoc-Lys(Boc)-PAB-OH
  • HY-W338516

    Amino Acid Derivatives Others
    Fmoc-L-Homoarginine hydrochloride is a derivative of amino acid with protecting groups. Fmoc-L-Homoarginine hydrochloride can be used for synthesis of homoarginine containing peptide .
    Fmoc-L-Homoarginine hydrochloride
  • HY-W010712S1

    Isotope-Labeled Compounds Amino Acid Derivatives Others
    Fmoc-His(Trt)-OH- 15N3 is the 15N labeled Fmoc-His(Trt)-OH (HY-W010712). Fmoc-His (Trt)-OH is a histidine derivative. Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation .
    Fmoc-His(Trt)-OH-15N3

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