82911-69-1
Chemical Structure
Fmoc-OSu
Synonym(s): N-(Fmoc-oxy)succinimide
- CAS. Nr.: 82911-69-1
- Formula:C19H15NO5
- Molecular Weight:337.33
IUPAC Name: (9H-fluoren-9-yl)methyl (2,5-dioxopyrrolidin-1-yl) carbonate
InChIKey: WMSUFWLPZLCIHP-UHFFFAOYSA-N
SMILES: O=C(N1OC(OCC2C3=CC=CC=C3C4=CC=CC=C24)=O)CCC1=O
Biological Activity: Fmoc-OSu (N-(Fmoc-oxy)succinimide) is an acylating agent that targets amino groups (-NH2). It can selectively protect the amino groups of amino acids by covalently binding with primary or secondary amines through nucleophilic substitution reactions. Fmoc-OSu forms a stable amide bond with the amino group to avoid side reactions of the amino group in peptide synthesis. It can also be used as a fluorescent labeling reagent to react with glycosylamines for efficient labeling of N-sugar chains. Fmoc-OSu can be used as an Fmoc protection strategy in peptide synthesis, and as a fluorescent labeling and analysis method for N-sugar chains[1][2].
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Fmoc-OSu | 99.88% | Fmoc-OSu (N-(Fmoc-oxy)succinimide) is an acylating agent that targets amino groups (-NH2). It can selectively protect the amino groups of amino acids by covalently binding with primary or secondary amines through nucleophilic substitution reactions. Fmoc-OSu forms a stable amide bond with the amino group to avoid side reactions of the amino group in peptide synthesis. It can also be used as a fluorescent labeling reagent to react with glycosylamines for efficient labeling of N-sugar chains. Fmoc-OSu can be used as an Fmoc protection strategy in peptide synthesis, and as a fluorescent labeling and analysis method for N-sugar chains. | ||||||||||||||||||||
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- [1]. Obkircher M, et al. Formation of Fmoc-beta-alanine during Fmoc-protections with Fmoc-OSu. J Pept Sci. 2008 Jun;14(6):763-6. [Content Brief]
- [2]. Wang C, et al. Fmoc N-hydroxysuccinimide ester: A facile and multifunctional role in N-glycan analysis. Anal Chim Acta. 2020 Sep 22;1131:56-67. [Content Brief]
Keywords
