136030-33-6
Chemical Structure
Fmoc-Tic-OH
- CAS No.: 136030-33-6
- Formula:C25H21NO4
- Molecular Weight:399.44
IUPAC Name: (S)-2-(((9H-fluoren-9-yl)methoxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
InChIKey: LIRBCUNCXDZOOU-QHCPKHFHSA-N
SMILES: O=C(N1CC2=C(C=CC=C2)C[C@H]1C(O)=O)OCC3C4=C(C5=C3C=CC=C5)C=CC=C4
Biological Activity: Fmoc-Tic-OH, an Fmoc-protected derivative of Tic, is a solid-phase peptide synthesis monomer. Fmoc-Tic-OH protects the amino group of Tic via a base-labile Fmoc group, allowing conformationally constrained Tic residues to be stepwise coupled to peptide chains, and the Fmoc protecting group can be removed under piperidine conditions. Fmoc-Tic-OH can be used for peptide synthesis and opioid receptor ligand research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fmoc-Tic-OH | 99.38% | Fmoc-Tic-OH, an Fmoc-protected derivative of Tic, is a solid-phase peptide synthesis monomer. Fmoc-Tic-OH protects the amino group of Tic via a base-labile Fmoc group, allowing conformationally constrained Tic residues to be stepwise coupled to peptide chains, and the Fmoc protecting group can be removed under piperidine conditions. Fmoc-Tic-OH can be used for peptide synthesis and opioid receptor ligand research. | ||||||||||||||||||||
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References
- [1]. Kumar V, et al. A solid-phase synthetic strategy for labeled peptides: synthesis of a biotinylated derivative of the delta opioid receptor antagonist TIPP (Tyr-Tic-Phe-Phe-OH). Organic letters. 2003 Mar 06;5(5):613-6. [Content Brief]
- [2]. Balboni G, et al. Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism. Journal of medicinal chemistry. 2004 Jul 29;47(16):4066-71.
