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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
FoxA
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "FoxA" in MCE Product Catalog:
Cat. No.: HY-168534
CAS No.: 2929223-35-6
WX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of SF3B1. WX-02-23 remodels FOXA1's chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis. WX-02-23 can be used for research on cancers such as prostate cancer .
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NR2F2-IN-1 (free base) is a COUP-TFII (orphan nuclear receptor NR2F2) inhibitor with antitumor activity against prostate cancer. NR2F2-IN-1 (free base) directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators including FOXA1. NR2F2-IN-1 (free base) can be used for the research of prostate cancer .
Synonyms: Desferrioxamine E; Nocardamin
Cat. No.: HY-RS05037
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FOXA2 Human Pre-designed siRNA Set A contains three designed siRNAs for FOXA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-156190
CAS No.: 1049691-47-5
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NR2F2-IN-1 is a COUP-TFII (orphan nuclear receptor NR2F2) inhibitor with antitumor activity against prostate cancer. NR2F2-IN-1 directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators including FOXA1. NR2F2-IN-1 can be used for the research of prostate cancer .
Cat. No.: HY-179433
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PROTAC AR Degrader-12 is a highly efficient PROTAC targeting AR coactivator binding site (AR-CBS). PROTAC AR Degrader-12 induces AR degradation in a ubiquitin proteasome system (UPS) pathway-dependent manner. PROTAC AR Degrader-12 inhibits tumor cell growth by affecting DNA replication and cell division PROTAC AR Degrader-12 could not only effectively degrade AR, but also potently inhibit the proliferation of MCF-7 and multiple mutant or resistant BC cells. PROTAC AR Degrader-12 effectively blocked estrogen receptor α (ERα) signaling through a dual mechanism involving ERα protein downregulation and suppression of its transcriptional activity. PROTAC AR Degrader-12 significantly inhibits the mRNA expression of FOXA1, GREB1, SRC, and PELP1. PROTAC AR Degrader-12 can be used for the study of breast cancer .
Cat. No.: HY-RS05036
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FOXA1 Human Pre-designed siRNA Set A contains three designed siRNAs for FOXA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-174679
Human FOXA2 mRNA encodes the human forkhead box A2 (FOXA2) protein, a member of the forkhead class of DNA-binding proteins. FOXA2 is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues.
Cat. No.: HY-RS05038
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FOXA3 Human Pre-designed siRNA Set A contains three designed siRNAs for FOXA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23794
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Foxa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Foxa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-174681
Human FOXA1 mRNA encodes the human forkhead box A1 (FOXA1) protein, a member of the forkhead class of DNA-binding proteins. FOXA1 is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues.
Cat. No.: HY-174678
Human FOXA3 mRNA encodes the human forkhead box A3 (FOXA3) protein which is thought to act as a ''pioneer'' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites.
Cat. No.: HY-RS17339
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Foxa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Foxa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18820
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Foxa2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Foxa2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20927
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Foxa3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Foxa3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25310
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Foxa2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Foxa2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27444
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Foxa3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Foxa3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-185180
CAS No.: 14836-73-8
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Ferrioxamine B is a bacterial desferrioxamine siderophore produced by actinomycetes. Ferrioxamine B acts as a ligand for FpvB and FoxA, and is transported into Pseudomonas aeruginosa via the FpvB and FoxA transporters. Ferrioxamine B competitively binds to FpvB, thereby antagonizing the uptake of thiostrepton into Pseudomonas aeruginosa. Ferrioxamine B can provide an iron source to support the growth of Pseudomonas aeruginosa under iron-limiting conditions .
Cat. No.: HY-181421
CAS No.: 2929223-36-7
WX-02-43 is a weak covalent inhibitor of SF3B1, and is the (1S,3R) enantiomer of WX-02-23 (HY-168534). WX-02-43 cannot effectively covalently modify the C258 site in the DNA-binding domain of FOXA1, and its inhibitory activity against SF3B1 is also weaker than that of WX-02-23. WX-02-43 serves as a negative control probe that fails to remodel the chromatin binding pattern and transcriptional activity of FOXA1. WX-02-43 can be used in studies on cancers such as prostate cancer to verify the specific effects of WX-02-23 on FOXA1 and SF3B1 targets .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
