FOXA
Forkhead Box A
The FOXA transcription factor family contains paradigm mammalian pioneer factors. FOXA factors have recently been shown to bind and induce changes in chromatin accessibility during early liver and pancreatic development. FOXA is a forkhead transcription factor that is expressed in the endoderm lineage across metazoans. Many studies have shown that the forkhead box (FOX) protein subfamily FOXA has a role in regulating glucolipid metabolism and is closely related to hepatic steatosis and nonalcoholic fatty liver disease (NAFLD). FOXA belongs to the Forkhead box protein family, which includes FOXA1, FOXA2 and FOXA3. FOXA can participate in a variety of complex cellular processes and play an important role in many diseases, such as liver fibrosis, hepatocellular carcinoma[1][2].
References:
- [1]. Heslop JA, et al. FoxA factors: the chromatin key and doorstop essential for liver development and function. Genes Dev. 2020 Aug 1;34(15-16):1003-1004. [Content Brief]
- [2]. Yu C, et al. The role of FOXA family transcription factors in glucolipid metabolism and NAFLD. Front Endocrinol (Lausanne). 2023 Jan 31;14:1081500. [Content Brief]
FOXA Isoform Specific Products
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FOXA Related Products (1)
Related Products (1)
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FOXA Isoform Comparison
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WX-02-23
0 ImagesWX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of SF3B1. WX-02-23 remodels FOXA1's chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis. WX-02-23 can be used for research on cancers such as prostate cancer.
