FOXA1
FOXA1 belongs to FOXA protein family. FOXA contains a winged helix structure necessary for binding to the target DNA, the structure consists of three alpha-helices arranged in a helix-turn-helix core flanked by rings. FOXA1, 2 and 3 have substantial homology in the DNA binding domain, FOXA1 has 95% sequence homology with FOXA3 and 90% homology with FOXA2. FOXA1 gene-inactivated mice died early in life, but their livers appeared histologically normal. Mice with islet-specific deficiency of FOXA1 exhibited decreased glucose-stimulated insulin release and reduced pancreatic insulin content. Consistent with the reduction in glucagon gene expression levels, the content of glucagon was reduced in FOXA1-, FOXA2-, and FOXA1/FOXA2-deficient α cells, and it seems that only the combined silencing of FOXA1 and FOXA2 can affect the secretion of glucagon[1].
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FOXA1 Related Products (1)
Related Products (1)
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WX-02-23
0 ImagesWX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of SF3B1. WX-02-23 remodels FOXA1's chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis. WX-02-23 can be used for research on cancers such as prostate cancer.
