2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. FOXA
  5. FOXA1 Isoform

FOXA1

FOXA1 belongs to FOXA protein family. FOXA contains a winged helix structure necessary for binding to the target DNA, the structure consists of three alpha-helices arranged in a helix-turn-helix core flanked by rings. FOXA1, 2 and 3 have substantial homology in the DNA binding domain, FOXA1 has 95% sequence homology with FOXA3 and 90% homology with FOXA2. FOXA1 gene-inactivated mice died early in life, but their livers appeared histologically normal. Mice with islet-specific deficiency of FOXA1 exhibited decreased glucose-stimulated insulin release and reduced pancreatic insulin content. Consistent with the reduction in glucagon gene expression levels, the content of glucagon was reduced in FOXA1-, FOXA2-, and FOXA1/FOXA2-deficient α cells, and it seems that only the combined silencing of FOXA1 and FOXA2 can affect the secretion of glucagon[1].

FOXA1 Related Products (1):

Cat. No. Product Name Effect Purity
  • HY-168534
    WX-02-23
    		99.88%
    WX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of SF3B1. WX-02-23 remodels FOXA1's chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis. WX-02-23 can be used for research on cancers such as prostate cancer.