2929223-35-6
Chemical Structure
WX-02-23
- CAS No.: 2929223-35-6
- Formula:C26H25N3O5
- Molecular Weight:459.49
InChIKey: YCIHYSVUQSOVJT-NBGIEHNGSA-N
SMILES: O=C(C=C)N([C@H](C(N1CCOCC1)=O)C2)[C@H](C3=CC=C(OCO4)C4=C3)C5=C2C6=C(N5)C=CC=C6
Biological Activity: WX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of SF3B1. WX-02-23 remodels FOXA1's chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis. WX-02-23 can be used for research on cancers such as prostate cancer[1][2][3][4].
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WX-02-23 | 99.88% | WX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of SF3B1. WX-02-23 remodels FOXA1's chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis. WX-02-23 can be used for research on cancers such as prostate cancer. | ||||||||||||||||||||
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- [1]. Won SJ, et al. Redirecting the pioneering function of FOXA1 with covalent small molecules. Mol Cell. 2024;84(21):4125-4141.e10. [Content Brief]
- [2]. Khan KS, et al. A small molecule that reshapes the chromatin dynamics of FOXA1. Mol Cell. 2024;84(21):4049-4051. [Content Brief]
- [3]. Amorello AN, et al. SF3B1 thermostability as an assay for splicing inhibitor interactions. J Biol Chem. 2025;301(2):108135. [Content Brief]
- [4]. Lazear MR, et al. Proteomic discovery of chemical probes that perturb protein complexes in human cells. Mol Cell. 2023;83(10):1725-1742.e12. [Content Brief]
Keywords
