FOXA1 Antibody (YA1102)
(Synonyms: FOXA1; Forkhead box A1; Forkhead box protein A1; HNF-3-alpha; TCF3A; HNF3A; Transcription factor 3A)FOXA1 Antibody (YA1102) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXA1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.152.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
FOXA1 Antibody (YA1102) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXA1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 49 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 49 kDa
Recombinant protein of human FOXA1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.152.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FOXA1 belongs to FOXA protein family. FOXA contains a winged helix structure necessary for binding to the target DNA, the structure consists of three alpha-helices arranged in a helix-turn-helix core flanked by rings. FOXA1, 2 and 3 have substantial homology in the DNA binding domain, FOXA1 has 95% sequence homology with FOXA3 and 90% homology with FOXA2. FOXA1 gene-inactivated mice died early in life, but their livers appeared histologically normal. Mice with islet-specific deficiency of FOXA1 exhibited decreased glucose-stimulated insulin release and reduced pancreatic insulin content. Consistent with the reduction in glucagon gene expression levels, the content of glucagon was reduced in FOXA1-, FOXA2-, and FOXA1/FOXA2-deficient α cells, and it seems that only the combined silencing of FOXA1 and FOXA2 can affect the secretion of glucagon[1].
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:It is highly expressed in prostate cancer and ESR1-positive breast tumors. It is overexpressed in esophageal adenocarcinoma and lung adenocarcinoma. -
Isoforms & Post-Translational Modification
P55317 has 2 isomers: P55317-1: 49148 Da (predicted); P55317-2: 45468 Da (predicted).
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Subunit
Binds DNA as a monomer (By similarity). Interacts with FOXA2. Interacts with NKX2-1. Interacts with HDAC7. Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A. Interacts with AR. Interacts with NR0B2 (By similarity)
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SwissProt ID
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Synonyms
FOXA1; Forkhead box A1; Forkhead box protein A1; HNF-3-alpha; TCF3A; HNF3A; Transcription factor 3A
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Research Field
Epigenetics and Nuclear Signaling
Documentation
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