FOXA1 - forkhead box A1 Gene

Also Known as HNF3A; TCF3A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3169

About FOXA1

Cytogenetic location: 14q21.1 Genomic coordinates (GRCh38): 14:37,589,552-37,595,249 (from NCBI)

This gene has 5 transcripts (splice variants), 147 orthologues, 42 paralogues and is associated with 71 phenotypes. Biased expression in prostate (RPKM 46.5), urinary bladder (RPKM 12.0) and 6 other tissues.

Summary

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]

FOXA1 Products (1)

mRNA Protein Name
NM_004496.5 NP_004487.2 hepatocyte nuclear factor 3-alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
9931457 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
25802280 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22722839 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
16087863 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
20160041 GOA
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
16087863 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
19127412 GOA
involved in positive regulation of intracellular estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16087863 GOA
involved in positive regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
16087863 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16331276 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16087863 GOA
involved in response to estradiol IDA
IDA: Inferred from direct assay
16087863 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9931457 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXA1 Protein Structure

Forkhead_N

Forkhead_N: Forkhead N-terminal region (17 - 169)

Forkhead

Forkhead: Forkhead domain (170 - 265)

HNF_C

HNF_C: HNF3 C-terminal domain (397 - 461)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
Protein Preferred Names Protein Names

hepatocyte nuclear factor 3-alpha

  • HNF-3-alpha

FOXA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81357 FOXA1 Antibody (YA1102) IHC-P Human
HY-P81357A FOXA1 Antibody (YA1102)(PBS only) IHC-P Human
HY-P86243 FOXA1 Antibody (YA5935) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Miliaria Profunda

  • Icd10cm:L74.2

  • Snomedct_us_2020_03_01:47317002
Apocrine Sweat Gland Neoplasm

  • Apocrine Tumor

  • Apocrine Neoplasm
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Breast Lobular Carcinoma

  • Cancer, Breast, Lobular

  • Lobular Breast Carcinoma
Suppression Of Tumorigenicity 12

  • Prostate Adenocarcinoma

  • Adenocarcinoma Of Prostate

  • ST12

  • Prostate Adenocarcinoma 1

  • Pac1
Estrogen-Receptor Negative Breast Cancer
Estrogen-Receptor Positive Breast Cancer
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Colon Leiomyoma

  • Colonic Leiomyoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168534 WX-02-23 99.88% Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FOXA1 VGNC VGNC:53490
Rattus norvegicus FOXA1 RGD RGD:2807
Mus musculus FOXA1 MGD MGI:1347472
Bos taurus FOXA1 VGNC VGNC:29077
Macaca mulatta FOXA1 VGNC VGNC:72707
Felis catus FOXA1 VGNC VGNC:67600
Others FOXA1 NCBI