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  4. NR2F2-IN-1 free base

NR2F2-IN-1 (free base) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F2-IN-1 (free base) substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F2-IN-1 (free base) directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation.

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NR2F2-IN-1 free base Chemical Structure

NR2F2-IN-1 free base Chemical Structure

CAS No. : 452087-38-6

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Based on 1 publication(s) in Google Scholar

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Description

NR2F2-IN-1 (free base) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F2-IN-1 (free base) substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F2-IN-1 (free base) directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation[1].

Molecular Weight

329.42

Formula

C17H19N3O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC(C(OC)=C1)=CC=C1CCNC2=C3C=C(C)SC3=NC=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (379.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0356 mL 15.1782 mL 30.3564 mL
5 mM 0.6071 mL 3.0356 mL 6.0713 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0356 mL 15.1782 mL 30.3564 mL 75.8910 mL
5 mM 0.6071 mL 3.0356 mL 6.0713 mL 15.1782 mL
10 mM 0.3036 mL 1.5178 mL 3.0356 mL 7.5891 mL
15 mM 0.2024 mL 1.0119 mL 2.0238 mL 5.0594 mL
20 mM 0.1518 mL 0.7589 mL 1.5178 mL 3.7945 mL
25 mM 0.1214 mL 0.6071 mL 1.2143 mL 3.0356 mL
30 mM 0.1012 mL 0.5059 mL 1.0119 mL 2.5297 mL
40 mM 0.0759 mL 0.3795 mL 0.7589 mL 1.8973 mL
50 mM 0.0607 mL 0.3036 mL 0.6071 mL 1.5178 mL
60 mM 0.0506 mL 0.2530 mL 0.5059 mL 1.2648 mL
80 mM 0.0379 mL 0.1897 mL 0.3795 mL 0.9486 mL
100 mM 0.0304 mL 0.1518 mL 0.3036 mL 0.7589 mL
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NR2F2-IN-1 free base Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NR2F2-IN-1452087-38-6OthersCOUP-TFII ,NR2F2orphan nuclear receptorInhibitorinhibitorinhibit

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