Ferrioxamine B 

Ferrioxamine B is a bacterial desferrioxamine siderophore produced by actinomycetes. Ferrioxamine B acts as a ligand for FpvB and FoxA, and is transported into Pseudomonas aeruginosa via the FpvB and FoxA transporters. Ferrioxamine B competitively binds to FpvB, thereby antagonizing the uptake of thiostrepton into Pseudomonas aeruginosa. Ferrioxamine B can provide an iron source to support the growth of Pseudomonas aeruginosa under iron-limiting conditions^[1].

Ferrioxamine B-Fe³⁺ (1 hour) binds FpvB in P. aeruginosa PA14 ΔfpvA ΔfpvB mutant with two distinct sites (K_d1 = 100 ng/mL, K_d2 = 270,000 ng/mL) and is taken up via a proton motive force-dependent mechanism^[1].
Ferrioxamine B (0.0-10 μg/mL) competes with thiostrepton (0.0-17 μg/mL) for binding to FpvB in P. aeruginosa PA14 ΔfpvA ΔfpvB mutant, reducing Thiostrepton (HY-B0990) susceptibility^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

613.51

C₂₅H₄₅FeN₆O₈

14836-73-8

NCCCCCN1[O-][Fe+3]23([O]=C1CCC4=O)([O-]N(CCCCCN5)C(C)=[O]3)[O-]N(CCCCCN4)C(CCC5=O)=[O]2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chan DCK, et al. Pseudomonas aeruginosa FpvB Is a High-Affinity Transporter for Xenosiderophores Ferrichrome and Ferrioxamine B. mBio. 2023;14(1):e0314922.  [Content Brief]