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By Research Areas:	Cancer (517) Cardiovascular Disease (200) Endocrinology (78) Infection (199) Inflammation/Immunology (419) Metabolic Disease (314) Neurological Disease (385)
Click Chemistry:	ADC Synthesis (1) TCO (3) Labeling and Fluorescence Imaging (6) DBCO (36) PROTAC Synthesis (1) BCN (2) Azide (9) Tetrazine (5) Alkynes (12)
Oligonucleotides:	Thymine Nucleotide (1) Solvents (2) Preservatives (1) Cosolvents (1) Nucleotide Analogs (3) mRNA (1) Phospholipids (3) siRNA drugs (2) Antisense Oligonucleotides (5) Cytidine Nucleotide (1) Cholesterol (1) siRNAs (2) pH Modifiers (1) Antioxidants (1) Pegylated Lipids (3) Guanine Nucleotide (1) Aptamers (1) Polymers (1) Chelating Agents (1)

2095

Inhibitors & Agonists

Screening Libraries

122

Fluorescent Dye

134

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

322

Natural
Products

418

Recombinant Proteins

152

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133852A

*FD-1080 free* acid** 1 Publications Verification	Fluorescent Dye	Others
FD-1080 free acid is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 free acid can be used for in vivo imaging .

HY-120801A

*APX-115 free* base** 2 Publications Verification Ewha-18278 Free base; Isuzinaxib Free base	NADPH Oxidase	Inflammation/Immunology Endocrinology
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with K_i values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury .

HY-108717A

*Recombinant Proteinase K (DNase & RNase free, animal free)* 2 Publications Verification Recombinant Protease K (DNase & RNase Free, animal Free)	Ser/Thr Protease	Others
Recombinant Proteinase K (Protease K) (DNase & RNase free, animal free) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K (DNase & RNase free, animal free) is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K (DNase & RNase free, animal free) can be use for promoting methods of viral nucleic acid extraction, and detection. This product is of molecular biology grade, free of animal-derived ingredients, and is recombinantly purified from yeast .

HY-19806

Ceftolozane CXA-101 Free base; FR264205 Free base	Antibiotic Bacterial	Infection
Ceftolozane (CXA-101 free base; FR264205 free base) is a cephalosporin antibiotic with potent activity againstPseudomonas aeruginosa and strains Enterobacteriaceae, with MICs of 0.5 and 0.25-0.5 mg/L .

HY-100444

*SIS3 free* base** 105+ Cited Publications	TGF-beta/Smad	Inflammation/Immunology
SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2 .

HY-174406A

*MT-125 free* base**	Myosin PDGFR Reactive Oxygen Species (ROS) Ferroptosis Akt mTOR ERK	Inflammation/Immunology Cancer
MT-125 free base is a specific and well-tolerated inhibitor of non-muscle myosin IIA (K_i,NMIIA = 2.7 μM) and IIB (EC₅₀ = 1.7 μM). MT-125 free base can pass through the blood-brain barrier. MT-125 free base induces ferroptosis and DNA damage by increasing the levels of reactive oxygen species (ROS) within tumor cells. MT-125 free base can enhance the PDGFR signaling pathway. MT-125 free base can be used for research on glioblastoma.

HY-B1354

Cefpiramide SM-1652 Free acid; Wy-44635 Free acid	Beta-lactamase Antibiotic Bacterial	Infection
Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase .

HY-W030796

*Lactisole free* acid** 3 Publications Verification	Taste Receptor	Metabolic Disease
Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets .

HY-13342AS

*Apatinib-d8 free* base** YN968D1-d8 Free base	Src VEGFR Autophagy c-Kit RET	Cancer
Apatinib-d₈ (free base) is the deuterium labeled Apatinib free base . Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC₅₀=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC₅₀s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ .

HY-W098021

2,2-Dimethoxy-2-phenylacetophenone Photoinitiator-651	Biochemical Assay Reagents	Others
2,2-Dimethoxy-2-phenylacetophenone is a hydrophobic benzoin ether-based free radical photoinitiator. 2,2-Dimethoxy-2-phenylacetophenone undergoes α-cleavage upon UV irradiation to generate benzoyl and substituted benzyl free radicals, thereby initiating photopolymerization reactions. 2,2-Dimethoxy-2-phenylacetophenone serves as a hydrophobic free radical photoinitiator for the photopolymerization of acrylamide and trimethylolpropane triacrylate in specific systems .

HY-108882D

Recombinant DNase I Protease & RNase free, animal free	DNA/RNA Synthesis	Others
Recombinant DNase I (Protease & RNase free, animal free) is a recombinant deoxyribonuclease that degrades DNA. Recombinant DNase I (Protease & RNase free, animal free) is essential for limiting inflammatory responses and maintaining homeostasis. This product is recombinant bovine pancreatic DNase I, purified by chromatography, free of animal-derived components, RNase and protease, and contains glycine as a stabilizer .

HY-139192A

*Brophenexin free* base** 3 Publications Verification NMDAR/TRPM4-IN-2 Free base	iGluR TRP Channel ERK	Neurological Disease
Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC₅₀ of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss .

HY-135218A

*AV-153 free* base** 1 Publications Verification	DNA/RNA Synthesis	Cancer
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity .

HY-106408

Nelonemdaz Salfaprodil Free base; Neu2000	iGluR	Neurological Disease
Nelonemdaz (Salfaprodil free base) is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Nelonemdaz is also a free radical scavenger. Nelonemdaz has excellent neuroprotection against NMDA- and free radical-induced cell death .

HY-107607

*FPL-55712 free* base**	Leukotriene Receptor	Inflammation/Immunology
FPL-55712 free base is a leukotriene receptor antagonist. FPL-55712 free base is also an antagonist of slow reacting substance of anaphylaxis (*SRS-A). FPL-55712 free* base inhibits leukotriene-induced bronchoconstriction .**

HY-16031

*AFP464 free* base** NSC710464 Free base	Aryl Hydrocarbon Receptor Integrin Drug Intermediate DNA/RNA Synthesis	Cancer
AFP464 (NSC710464) free base is a prodrug of Aminoflavone (HY-132974) and an agonist of the aryl hydrocarbon receptor (AhR). AFP464 free base downregulates the expression of α6-integrin (α6-integrin), inhibits breast tumor growth, reduces the population of tumor-initiating cells, disrupts mammosphere structure, induces the formation of mucin lake clusters, triggers DNA damage, and exerts antiproliferative activity. AFP464 free base is rapidly converted to Aminoflavone by nonspecific esterases in plasma and cell culture media. AFP464 free base is applicable to research related to breast cancer .

HY-W883690

*LacK free* acid**	Endogenous Metabolite	Others
LacK (free acid) is a lysine derivative used in lactate acylation studies .

HY-148529

Midaglizole (±)-DG5128 Free base; DG5128 Free base	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease
Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo .

HY-P0252B

*α-MSH free* acid** α-Melanocyte-Stimulating Hormone Free acid	Melanocortin Receptor	Neurological Disease
α-MSH free acid (α-Melanocyte-Stimulating Hormone free acid) is an MC3R and MC4R agonist with EC₅₀s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R .

HY-P2932A

*Cholecystokinin-33 free* acid**	Cholecystokinin Receptor	Neurological Disease
Cholecystokinin-33 free acid is an analogue of Cholecystokinin (HY-P2932). C-terminal amidation is important for binding of Cholecystokinin to its receptors, and removing the amide group would decrease Cholecystokinin activity. Cholecystokinin-33 free acid can be used to study C-terminal amidation of Cholecystokinin-33 .

HY-15685A

*Ripasudil free* base** K-115 Free base	ROCK	Neurological Disease
Ripasudil free base (K-115 free base) is a specific inhibitor of ROCK, with IC₅₀s of 19 and 51 nM for ROCK2 and ROCK1, respectively.

HY-P3906

*Melittin free* acid**	Fungal Apoptosis Phospholipase Reactive Oxygen Species (ROS)	Infection
Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways .

HY-147039

*BOLD-100 free* base** NKP-1339 Free base; IT-139 Free base; KP-1339 Free base	HSP Autophagy	Cancer
BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution .

HY-120973

*Butaprost free* acid**	Prostaglandin Receptor TGF-beta/Smad	Endocrinology
Butaprost free acid is a selective prostaglandin E receptor (EP2) agonist with an EC₅₀ of 33 nM and a K_i of 2.4 μM for murine EP2 receptor. Butaprost free acid is less activity against murine EP1, EP3 and EP4 receptors. Butaprost free acid attenuates fibrosis by hampering TGF-β/Smad2 signalling .

HY-131003A

*Taletrectinib free* base** DS-6051b Free base; AB-106 Free base; IBI-344 Free base	ROS Kinase	Cancer
Taletrectinib (DS-6051b) free base is a potent, orally active, and next-generation selective ROS1/NTRK inhibitor. Taletrectinib free base potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC₅₀s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib free base also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants .

HY-122613

*YM543 free* base**	SGLT	Metabolic Disease
YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes .

HY-112095

*EVT-101 free* base** ENS-101 Free base	iGluR	Neurological Disease
EVT-101 free base is a GluN₂B antagonist. EVT-101 free base binds at the same GluN₁/GluN₂B dimer interface as Ifenprodil (HY-12882). EVT-101 free base inhibits calcium influx in chicken-derived cells, with an EC₅₀ of 22 nM. EVT-101 can be used in the research of brain disorders .

HY-15960

*PWT-33597 free* base** VDC-597 Free base	PI3K mTOR Apoptosis	Cancer
PWT-33597 (VDC-597) free base is a dual inhibitor of PI3Kα and mTOR, which can effectively block the signaling downstream of PI3K and mTOR. PWT-33597 free base is capable of inducing tumor cell apoptosis and inhibiting tumor growth. PWT-33597 free base has anti-tumor activity and can be used in the research of tumors such as renal cell carcinoma .

HY-W369099

*HJC0152 free* base**	STAT Apoptosis	Cancer
HJC0152 (free base) is an orally active and potent inhibitor of STAT3. HJC0152 (free base) inhibits cell cycle progression and induces apoptosis. HJC0152 (free base) significantly suppresses MDA-MB-231 xenograft tumor growth in mice .

HY-106912A

*L-706000 free* base** MK 499 Free base	Potassium Channel	Cardiovascular Disease
L-706000 (MK 499) free base is a potent hERG channel blocker with an IC₅₀ of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias .

HY-167902

*YM-31636 free* base**	5-HT Receptor	Metabolic Disease
YM-31636 free base is an orally active, potent and selective 5-HT₃ receptor agonist with a K_i value of 0.2 nM. YM-31636 free base induces contraction of isolated guinea pig distal colon. YM-31636 free base induces tachycardia with the relative intrinsic activity of approximately 0.23 in isolated guinea pig right atrium. YM-31636 free base is promising for research of constipation .

HY-120475B

*PBT434 free* base** ATH434 Free base	α-synuclein	Neurological Disease
PBT434 (ATH434) free base is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 free base can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 free base inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 free base prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 free base has the potential for the research of Parkinson’s disease (PD) .

HY-50733

*CX-5011 free* base**	Apoptosis Casein Kinase Ras	Cancer
CX-5011 free base is a potent CK2 inhibitor. CX-5011 free base also is a Rac-1 activator. CX-5011 free base induces methuosis and promotes macropinocytosis. CX-5011 free base induces apoptosis. CX-5011 free base decreases the expression of rpS6 phosphorylation .

HY-109118

*Masupirdine free* base** SUVN-502 Free base	5-HT Receptor	Neurological Disease
Masupirdine free base (SUVN-502 free base) is a potent, selective, orally active, and brain-penetrating 5-HT₆ receptor antagonist (K_i of 2.04 nM for human 5-HT₆ receptor). Masupirdine free base has pro-cognitive effects on all stages of cognition (acquisition, consolidation, and retention), and can reverse Scopolamine (HY-N0296), MK-801 (HY-15084B)-induced and aging-related memory deficits. Masupirdine free base can be used in the research of Alzheimer's disease .

HY-W705784

*T-1032 free* base**	Phosphodiesterase (PDE)	Others
T-1032 free base is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC₅₀ value of 1.0 nM. T-1032 free base shows relaxant effect on isolated rabbit corpus cavernosum. T-1032 free base can be used for the research of erectile dysfunction .

HY-19106

*MCI-727 free* base**	Secretin Receptor	Inflammation/Immunology Endocrinology
MCI-727 free base is an orally active anti-ulcer agent. MCI-727 free base can increase the plasma secretin concentration in rats and dogs. MCI-727 free base can also stimulate the exocrine function of the pancreas in rats by promoting the release of endogenous secretin, and exert preventive and therapeutic effects on mild acute pancreatitis. MCI-727 free base can be used in the research of ulcer-related diseases .

HY-W096638

Glycerylphosphorylcholine	Drug Intermediate	Others
Glycerylphosphorylcholine is a precursor of free choline in mammalian semen .

HY-106088

*Tibenelast free* acid** LY186655 Free acid	Phosphodiesterase (PDE)	Cardiovascular Disease
Tibenelast (LY186655) free acid is a potent and orally active is a phosphodiesterase inhibitor. Tibenelast free acid is an anti-asthma agent Tibenelast free acid increases the heart rate response to isoproterenol (HY-108353). Tibenelast free acid shows anti-anaphylactic shock activity. Tibenelast free acid has the potential for the research of asthma and other respiratory diseases .

HY-B1022A

*Dimesna free* acid** BNP-7787 Free acid	Drug Derivative	Endocrinology Cancer
Dimesna (BNP-7787) free acid, the disulfide form of Mesna (HY-13679), is a platinum-related toxicity protective agent. Dimesna free acid converts to Mesna, which in turn inactivates toxic platinum substances. Dimesna free acid does not interfere with the antitumor activity of platinum compounds. Dimesna free acid does not affect the antiproliferative effects of Cisplatin (HY-17394) or Carboplatin (HY-17393). Dimesna free acid counteracts Cisplatin-induced nephrotoxicity. Dimesna free acid exerts selective protective effects on the kidneys. Dimesna free acid can be used in studies related to ovarian cancer and Cisplatin-induced nephrotoxicity .

HY-172190A

*MS Medium (Agar-Free, Sucrose-Free)*	Biochemical Assay Reagents	Others
MS Medium (Agar-Free, Sucrose-Free) is a culture medium with a high concentration of inorganic salts and ions, making it a relatively stable balanced solution. The quantity and ratio of nutrients in MS Medium (Agar-Free, Sucrose-Free) are suitable to meet the nutritional and physiological needs of plants.

HY-D0116

*Pyranine free* acid** HPTS Free acid; Solvent Green 7 Free acid	Fluorescent Dye	Others
Pyranine (HPTS; Solvent Green 7) free acid is a pH-sensitive fluorescent indicator. Pyranine free acid acts as a class of fluorescent chemosensor for the Cu ⁺ ion. Pyranine free acid is used as a coloring agent, biological stain, optical detecting reagent, and pH indicator (Ex/Em = 450/510 nm) .

HY-106518

*Adimolol free* base** MEN-935 Free base	Adrenergic Receptor	Metabolic Disease
Adimolol (free base) (MEN 935 (free base)) is an antagonist of β- and α-adrenolytic receptor. Adimolol (free base) shows K_is of 5.2 x 10 ^-7, 1.3 x 10 ^-5 mol/L at α₁ and α₂ drenoceptors, respectively. Adimolol (free base) can be used for antihypertensive study .

HY-130320A

*Monophosphoryl lipid A free* acid** Glucopyranosyl lipid A Free acid	Toll-like Receptor (TLR)	Inflammation/Immunology
Monophosphoryl lipid A (free acid) is a toll-like receptor 4 agonist. Monophosphoryl lipid A (free acid) is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A (free acid) can be used for the research of immunization and vaccine .

HY-179182A

Hoagland Nutrient Solution Phosphorus-Free, Calcium nitrate-Free	Biochemical Assay Reagents	Others
Hoagland Nutrient Solution (Phosphorus-Free, Calcium nitrate-Free) is a nutrient solution for hydroponics of plants .

HY-N14699

Diphenicillin Ancillin Free acid; 2-Biphenylyl penicillin Free acid; SKF-12141 Free acid	Penicillin-binding protein (PBP) Bacterial	Infection
Diphenicillin (Ancillin (free acid); 2-Biphenylyl penicillin (free acid); SKF-12141 (free acid)) is a Penicillinase (HY-E70012)- resistant penicillin with antibacterial activity. Diphenicillin shows good antibacterial effects against Gram-positive cocci. Diphenicillin is promising for research of infectious diseases caused by Gram-positive cocci such as staphylococci, pneumococci, and group A streptococci .

HY-W250973

*Galvinoxyl free* radical**	Biochemical Assay Reagents	Others
Galvinoxyl free radical is a stable organism with free radicals .

HY-19651

*Zanapezil free* base** TAK-147 Free base	Cholinesterase (ChE)	Neurological Disease
Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC₅₀=51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with K_i values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD) .

HY-106358R

*Andolast free* base (Standard)** CR 2039 Free base (Standard); Dizolast Free base (Standard)	Reference Standards Phosphodiesterase (PDE)	Inflammation/Immunology
Andolast (free base) (Standard) is the analytical standard of Andolast (free base). This product is intended for research and analytical applications. Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma .

HY-117803

*CP 461 free* base** OSI-461 Free base	Apoptosis	Cancer
CP 461 free base (OSI-461 free base) is a novel pro-apoptotic compound with the activity of inhibiting cyclic guanosine monophosphate phosphodiesterase. CP 461 free base exhibits growth inhibitory activity against a variety of human tumor cell lines in vitro. CP 461 free base selectively induces apoptosis in cancer cell lines but has no effect on normal cells. CP 461 free base can be used in the study of renal cell carcinoma, prostate cancer and Crohn's disease .

HY-119379

*Fonsartan free* acid** HOE-720 Free acid	Angiotensin Receptor	Cardiovascular Disease
Fonsartan (HOE-720) free acid is an orally active angiotensin II receptor (AT1R) antagonist with an IC₅₀ value of 0.48 nM, exhibiting potent antihypertensive activity. Fonsartan free acid dose-dependently inhibits angiotensin II-induced pressor response in rats (ID₅₀ = 0.11 mg/kg) and shows significant long-lasting blood pressure-lowering effects in high-renin animal models. Fonsartan free acid is primarily used in research on hypertension and cardiovascular diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-D0187

L-Glutathione reduced Maximum Cited Publications 54 Publications Verification GSH; γ-L-Glutamyl-L-cysteinyl-glycine	Cardiovascular Disease Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite Reactive Oxygen Species (ROS) Ferroptosis
L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

HY-N0728

α-Linolenic acid 10+ Cited Publications ALA Free base; C18:3 (9Z,12Z,15Z) Free base; C18:3 n-3 Free base	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Labiatae Ulex europaeus L. Disease markers Plants Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Source Classification	Environmental Pollutants Akt PI3K
α-Linolenic acid (ALA (free base); C18:3 (9Z,12Z,15Z) (free base); C18:3 n-3 (free base)) is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-W015913

Pyruvic acid sodium 15+ Cited Publications Sodium 2-oxopropanoate; Acetylformic acid sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) Endogenous Metabolite
Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-B0451

Dopamine 20+ Cited Publications ASL279 Free base	Phenols Polyphenols Endogenous metabolite	Dopamine Receptor Endogenous Metabolite Ferroptosis
Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body . Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

HY-N0091

Hypoxanthine 10+ Cited Publications Purin-6-ol; Sarcine	Natural Products Microorganisms Classification of Application Fields Disease markers Other Diseases Endogenous metabolite Disease Research Fields Cancer Source Classification	Endogenous Metabolite
Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

HY-B0661

Tamsulosin 2 Publications Verification (R)-(-)-YM12617 Free base; LY253351 Free base	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Endocrinology Source Classification Cancer	Adrenergic Receptor Apoptosis
Tamsulosin ((R)-(-)-YM12617 free base) is an orally active antagonist of α₁-adrenergic receptor. Tamsulosin induces Apoptosis. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models .

HY-14769

Folitixorin 2 Publications Verification 5,10-Methylenetetrafolate; ANX-510 Free acid	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research .

HY-P1934A

Cyclo(L-Phe-L-Pro)	Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification Cancer	Fungal Bacterial IFNAR Reactive Oxygen Species (ROS)
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

HY-16468

Squalamine 1 Publications Verification MSI-1256; ENT-01 Free acid	Infection Triterpenes Animals Classification of Application Fields Terpenoids Marine natural products Other marine organisms Disease Research Fields Cancer	Bacterial HBV FAK Dengue Virus
Squalamine (MSI-1256) is an aminosterol compound with broad-spectrum antiviral activity. Squalamine makes cells less conducive to certain viral replication by altering the electrostatic interactions in the inner membrane of host cells. Squalamine also has antibacterial and antitumor activities. Squalamine has broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, fungi and protozoa. Squalamine inhibits tumor-related angiogenesis and the growth of human breast cancer cells. Squalamine restores the function of enteric nervous system in Parkinson ^,s disease mouse models .

HY-N1579

Pyrogallol 4 Publications Verification	Infection Microorganisms Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Fungal Apoptosis
Pyrogallol is a polyphenol compound, which has anti-fungal and anti-psoriatic properties. Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions.

HY-N1430

Oxyresveratrol 3 Publications Verification trans-Oxyresveratrol	other families Stilbenes Classification of Application Fields Anti-aging Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Tyrosinase HSV Autophagy
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .

HY-Y0678

1,3,5-Trimethoxybenzene 1 Publications Verification TRIMETHYL PHLOROGLUCINOL	Structural Classification Natural Products Rosaceae Plants Rosa rugosa Thunb. Source Classification	Biochemical Assay Reagents
1,3,5-Trimethoxybenzene (TRIMETHYL PHLOROGLUCINOL) is an electrophilic substitution reaction substrate targeting free chlorine (Cl ⁺) and free bromine (Br ⁺). 1,3,5-Trimethoxybenzene has highly selective electrophilic addition characteristics. By capturing halogens, it undergoes specific substitution reactions to generate stable halogenated products. 1,3,5-Trimethoxybenzene can not only quench residual oxidants, but also quantify the halogen concentration by detecting the product without affecting the stability of redox-sensitive disinfection byproducts (DBPs). 1,3,5-Trimethoxybenzene is mainly used in water quality testing and quantitative analysis of free chlorine/bromine in water. At the same time, in phytochemistry, it is a key component of rose fragrance and participates in the study of pollination attraction mechanism .

HY-N3220

Myricetin 3-O-galactoside 1 Publications Verification	Flavonols Flavonoids Rhododendron dauricum Linn. Classification of Application Fields Phenols Polyphenols Metabolic Disease Ericaceae Plants Disease Research Fields Source Classification	Xanthine Oxidase
Myricetin 3-O-galactoside inhibits xanthine oxidase (XO) activity, lipid peroxidation and scavenges the free radical. Myricetin 3-O-galactoside inhibits lipid peroxidation with an IC₅₀ of 160 μg/mL. Antioxidant activity .

HY-N0627

Kaempferol-7-O-β-D-glucopyranoside	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	LDLR
Kaempferol-7-O-β-D-glucopyranoside is a flavonoid glycoside. Kaempferol-7-O-β-D-glucopyranoside exists in the root bark of Cudrania tricuspidata. Kaempferol-7-O-β-D-glucopyranoside inhibits Cu ²⁺-induced lipid peroxidation of low-density lipoprotein. Kaempferol-7-O-β-D-glucopyranoside possesses antioxidant activity and scavenges DPPH free radicals .

HY-N2376

Chrysin-7-O-glucuronide 1 Publications Verification	Structural Classification Classification of Application Fields Flavones Plants Oroxylum indicum (Linn.) Bentham ex Kurz Monophenols Flavonoids Labiatae Other Diseases Phenols Bignoniaceae Medicago truncatula Gaertn. Disease Research Fields Source Classification	Glycosidase Amylases NF-κB
Chrysin-7-O-glucuronide is a flavonoid found in Scutellaria baicalensis. Chrysin-7-O-glucuronide inhibits α-glucosidase and α-amylase with IC₅₀ values of 612.13 and 980.73 μg/mL. Chrysin-7-O-glucuronide suppresses NF-κB signaling activity. Chrysin-7-O-glucuronide scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. Chrysin-7-O-glucuronide can be used for the research of type 2 diabetes and severe acute pancreatitis-induced intestinal mucosal barrier injury .

HY-105088

Pexiganan MSI 78 Free base	Infection Structural Classification Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification	Bacterial
Pexiganan (MSI 78) is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection .

HY-N4118

Cephaeline 1 Publications Verification (-)-Cephaeline; NSC 32944 Free base	Infection Alkaloids Monophenols other families Classification of Application Fields Phenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Filovirus Flavivirus Keap1-Nrf2 Ferroptosis Reactive Oxygen Species (ROS)
Cephaeline ((-)-Cephaeline), a desmethyl analog of Emetine, is a phenolic alkaloid in Indian Ipecac roots isolated from the Cephaelis ipecacuanha. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections. Cephaeline is an inductor of histone H3 acetylation and an inhibitor of mucoepidermoid carcinoma cancer stem cells (MEC), which promotes ferroptosis by inhibiting NRF2 to exert anti-lung cancer efficacy .

HY-B0093

Benazepril 2 Publications Verification CGS14824A Free base	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Angiotensin-converting Enzyme (ACE) Apoptosis Reactive Oxygen Species (ROS)
Benazepril (CGS14824A free base) is an orally active angiotensin-converting enzyme (ACE) inhibitor to reduce angiotensin-II production. Benazepril inhibits oxidative stress and inhibits apoptosis by the PI3K/Akt signaling pathway. Benazepril improves diabetic nephropathy and decreases proteinuria. Benazepril can be used in the study of hypertension, heart failure and diabetic nephropathy .

HY-N1478

Gardenoside 2 Publications Verification	Iridoids Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis Source Classification	P2X Receptor Reactive Oxygen Species (ROS)
Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS). Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study .

HY-N8220

2-(2-Phenylethyl)chromone Flidersiachromone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Thymelaeaceae Other Diseases Plants Aquilaria sinensis (Lour.) Spreng. Disease Research Fields Source Classification	Glycosidase
2-(2-Phenylethyl) chromone (Flidersiachromone) is a chromone derivative and antioxidant. 2-(2-Phenylethyl) chromone scavenges ABTS· ⁺ free radicals, and its derivatives exhibit diverse activities including anti-inflammatory, neuroprotective, anti-tumor, and α-glucosidase inhibitory effects. 2-(2-Phenylethyl) chromone is applicable to experimental research in fields such as inflammation-related diseases, tumors, and neurodegenerative diseases .

HY-N3558

Ceanothic acid Emmolic acid	Other Terpenoids Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Bacterial
Ceanothic acid (Emmolic acid) is an orally active pentacyclic triterpenoid. Ceanothic acid inhibits the growth of various oral bacteria, including Streptococcus mutans, Actinomyces viscosus, Porphyromonas gingivalis, and Prevotella intermedia. Ceanothic acid scavenges DPPH and H₂O₂ free radicals. Ceanothic acid inhibits acetic acid (HY-Y0319)-induced writhing response, xylene-induced ear swelling, and carrageenan-induced paw swelling in mice. Ceanothic acid can be used in research related to oral bacterial infections, ovarian cancer, liver cancer, and liver injury .

HY-N0642

α-L-Rhamnose monohydrate	Structural Classification other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Saccharides Monosaccharides Source Classification Cancer	Drug Derivative Calcium Channel
α-L-Rhamnose monohydrate is a neutral sugar present in plants, animals, viruses and bacteria. α-L-Rhamnose monohydrate is a ligand for α-L-rhamnose-recognizing lectin sites, trigger intracellular signaling pathways. α-L-Rhamnose monohydrate induces rhaE and rhaA expression as a specific carbon source in Aspergillus nidulans, while glucose inhibits its cellular uptake. α-L-Rhamnose monohydrate induces rapid and transient increases in intracellular free Ca ²⁺ concentration in normal human dermal fibroblasts .

HY-100528A

Dianemycin 3 Publications Verification Nanchangmycin Free acid	Infection Microorganisms Classification of Application Fields Antibiotics Antiviral Antibacterial Disease Research Disease Research Fields Polyether Antibiotics Source Classification	Bacterial Antibiotic Flavivirus
Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria . Nanchangmycin is a broad spectrum antiviral active against Zika virus .

HY-N10788

Pomonic acid	Triterpenes Structural Classification Terpenoids Verbenaceae Plants Lantana camaraLinn. Source Classification	Acyltransferase
Pomonic acid is an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor. Pomonic acid reduces the esterification of free cholesterol to cholesteryl esters and the accumulation of intracellular cholesteryl esters. Pomonic acid can be used in the research of atherosclerosis .

HY-B1777R

Spermine (Standard) NSC 268508 (Standard); Neuridine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Influenza Virus
Spermine (Standard) is the analytical standard of Spermine. This product is intended for research and analytical applications. Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects.

HY-N7607

Quercetin-3-O-D-glucosyl]-(1-2)-L-rhamnoside	Cardiovascular Disease Flavonols Flavonoids Ginkgoaceae Classification of Application Fields Phenols Polyphenols Plants Ginkgo biloba Disease Research Fields Source Classification	Reactive Oxygen Species (ROS)
Quercetin-3-O-D-glucosyl]-(1-2)-L-rhamnoside is a flavonoid glycoside with antioxidant activity and free radical scavenging activity. Quercetin-3-O-D-glucosyl]-(1-2)-L-rhamnoside can scavenge free radicals such as ABTS+ and can be used in the study of antioxidant-related diseases (such as cardiovascular diseases and neurodegenerative diseases) .

HY-P0303

*Crustacean cardioactive peptide，free* acid**	Cardiovascular Disease Natural Products Animals Neurological Disease Classification of Application Fields Disease Research Fields Source Classification	G Protein-coupled Receptor Kinase (GRK)
Crustacean cardioactive peptide, free acid is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean cardioactive peptide, free acid also modulates the neuronal activity in other arthropods.

HY-N10917

Xanthohumol I	Structural Classification Humulus lupulus L. Phenols Polyphenols Plants Moraceae Source Classification	Drug Derivative
Xanthohumol I is a derivative of Chalcone (HY-121054) that can be isolated from Humulus lupulus L. (hops). Xanthohumol I exhibits free radical scavenging activity .

HY-N1449

Neonuezhenide	Oleaceae Classification of Application Fields Ligustrum lucidum Ait. Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Others
Neonuezhenide exhibits strong antioxidant effect against hemolysis of red blood cells induced by free radicals .

HY-W051287

4-Hydroxy-2-butanone	Natural Products Cucurbitaceae Plants Source Classification Benincasa hispida (Thunb.) Cogn.	Endogenous Metabolite
4-Hydroxy-2-butanone is a free volatile component of glycoside precursors in wax gourd .

HY-128030

Makisterone A	Classification of Application Fields Chenopodium quinoa Willd. Plants Disease Research Fields Endocrinology Steroids Source Classification Chenopodiaceae	Others
Makisterone A, a 28-carbon moulting hormone, has been identified as the major free pupal ecdysteroid in the honey bee, Apis mellifera .

HY-124496

Piperitenone	Structural Classification Other Monoterpenes Terpenoids Labiatae Erythrina poeppigiana Plants Source Classification	Mitochondrial Metabolism Reactive Oxygen Species (ROS)
Piperitenone is a terpenoid, and exhibits antioxidant activity. Piperitenone scavenges DPPH free radicals with an IC₅₀ of 22.7 μg/mL, and inhibits the peroxidation of linoleic acid .

HY-100313

*YM-53601 free* base**	Alkaloids Carbazole Alkaloids	Farnesyl Transferase HCV
YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

HY-N8219

Isoarundinin II	Bletilla striata (Thunb. ex Murray) Rchb. f. Structural Classification Classification of Application Fields Orchidaceae Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Reactive Oxygen Species (ROS)
Isoarundinin II is a bibenzyl compound found in the pseudobulbs of Pleione grandiflora (Rolfe) Rolfe. Isoarundinin II scavenges DPPH free radicals .

HY-N3596

Cleomiscosin C Aquillochin	Thymelaeaceae Phenols Polyphenols Plants Aquilaria sinensis (Lour.) Spreng. Source Classification	Others
Cleomiscosin C (Aquillochin) can be isolated from Aquilaria agallocha. Cleomiscosin C has antioxidant activity. Cleomiscosin C inhibits LDL oxidation and free radicals generation .

HY-N8042

Erigeside I	Ulex europaeus L. Phenols Polyphenols Plants Compositae Saccharides Monosaccharides Source Classification	Others
Erigeside I is a free radical scavenger isolated from Erigeron breviscapus .

HY-N16309

*Cyanine 7 free* acid bromide**	Lipid	Fluorescent Dye
Cyanine 7 free acid bromide is a near-infrared fluorescent probe for labelling amine groups such as those on antibodies, nucleic acids, and proteins and can be detected using a variety of fluorescence detection techniques such as microscopy and flow cytometry.

HY-N10176

D-Isofloridoside	Cardiovascular Disease other families Classification of Application Fields Plants Disease Research Fields Saccharides Source Classification	Reactive Oxygen Species (ROS) MMP
D-Isofloridoside, one of the polysaccharide precursors, has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9 .

HY-N15684

Rhodoxanthin	Natural Products Animals Source Classification	Others
Rhodoxanthin is a carotenoid. Rhodoxanthin exerts antioxidant activity via free radical scavenging and lipid peroxidation inhibition. Rhodoxanthin is promising for research of oxidative stress-related diseases (e.g., UV-induced skin damage) .

HY-Y0678R

1,3,5-Trimethoxybenzene (Standard)	Structural Classification Natural Products Rosaceae Plants Rosa rugosa Thunb. Source Classification	Reference Standards Biochemical Assay Reagents
1,3,5-Trimethoxybenzene (TRIMETHYL PHLOROGLUCINOL) is an electrophilic substitution reaction substrate targeting free chlorine (Cl+) and free bromine (Br+). 1,3,5-Trimethoxybenzene has highly selective electrophilic addition characteristics. By capturing halogens, it undergoes specific substitution reactions to generate stable halogenated products. 1,3,5-Trimethoxybenzene can not only quench residual oxidants, but also quantify the halogen concentration by detecting the product without affecting the stability of redox-sensitive disinfection byproducts (DBPs). 1,3,5-Trimethoxybenzene is mainly used in water quality testing and quantitative analysis of free chlorine/bromine in water. At the same time, in phytochemistry, it is a key component of rose fragrance and participates in the study of pollination attraction mechanism .

HY-N16327

*Squarefluor 631/646 free* acid**	Lipid	Fluorescent Dye
Squarefluor 631/646 free acid is a squaraine probe (Ex/Em = 631/646 nm).

HY-106888

*CS-722 Free* base**	Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
CS-722 Free base is a synthesized centrally acting muscle relaxant, and has a muscle relaxant activity and depressant effectson the spinal reflex . CS-722 Free base inhibits spontaneous inhibitory postsynaptic currents and excitatory postsynaptic currents in hippocampal cultures probably by an inhibition of both sodium and calcium currents .

HY-N15440

Mutatochrome Citroxanthin	Natural Products Rosaceae Plants Rosa foetida Herrm. Source Classification	Reactive Oxygen Species (ROS) Endogenous Metabolite
Mutatochrome (Citroxanthin) is a naturally occurring carotenoid pigment found in certain plants. Mutatochrome has antioxidant property to help protect cells from damage caused by free radicals. Mutatochrome can be used for anti-inflammatory and anticancer study .

HY-W015913R

Pyruvic acid sodium (Standard) 5+ Cited Publications Sodium 2-oxopropanoate (Standard); Acetylformic acid sodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite
Sodium 2-oxopropanoate (Standard) is the analytical standard of Sodium 2-oxopropanoate. This product is intended for research and analytical applications. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-N3554

Catechin-7-O-β-D-xylopyranoside (+)-Catechol 7-β-D-xylopyranoside	Betula pendula Roth. Plants Saccharides Betulaceae Monosaccharides Source Classification	Others
Catechin-7-O-β-D-xylopyranoside is an antioxidant compound with strong DPPH free radical scavenging ability. Catechin-7-O-β-D-xylopyranoside can be extracted from birch inner bark and nepeta stem bark .

HY-N8955

Maritimein	Structural Classification Amburana cearensis (Allemão) A.C.Sm. Plants Compositae Saccharides Monosaccharides Source Classification	Reactive Oxygen Species (ROS)
Maritimein is an aurone glucoside and antioxidant with free radical scavenger activity, found in Coreopsis tinctoria Nutt.Maritimein scavenges ABTS•+ radical cations .

HY-N1478R

Gardenoside (Standard)	Structural Classification Iridoids Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis Source Classification	Reference Standards P2X Receptor Reactive Oxygen Species (ROS)
Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS). Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study .

HY-N14699

Diphenicillin Ancillin Free acid; 2-Biphenylyl penicillin Free acid; SKF-12141 Free acid	Natural Products Microorganisms Source Classification	Penicillin-binding protein (PBP) Bacterial
Diphenicillin (Ancillin (free acid); 2-Biphenylyl penicillin (free acid); SKF-12141 (free acid)) is a Penicillinase (HY-E70012)- resistant penicillin with antibacterial activity. Diphenicillin shows good antibacterial effects against Gram-positive cocci. Diphenicillin is promising for research of infectious diseases caused by Gram-positive cocci such as staphylococci, pneumococci, and group A streptococci .

HY-167885

*SN-35210 free* base**	Flavonoids Labiatae Cynara scolymus L. Plants Source Classification	iGluR
SN-35210 free base, an ester analogue, is designed for rapid offset via esterase-mediated hydrolysis .

HY-N16316

*Meso-Cl cyanine 7 free* acid chloride**	Lipid	Fluorescent Dye
Meso-Cl cyanine 7 free acid chloride is a Meso-Cl cyanine fluorescent dye. Meso-Cl cyanine 7 free acid chloride can be used for labelling amine groups such as those on antibodies, nucleic acids, and proteins and can be detected using a variety of fluorescence detection techniques such as microscopy and flow cytometry (Ex/Em = 778/805 nm) .

Cat. No.	Product Name	Chemical Structure

HY-D0187S

L-Glutathione reduced-13C2,15N
L-Glutathione reduced- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Glutathione reduced. L-Glutathione reduced (GSH) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

HY-W015913S

Pyruvic acid-13C3 sodium 1 Publications Verification
Sodium 2-oxopropanoate- ¹³C₃ is the ¹³C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-D0843S

N-Ethylmaleimide-d5
N-Ethylmaleimide-d₅ is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor . N-ethylmaleimide specific inhibits phosphate transport in mitochondria . N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor .

HY-B0351S

Taurine-d4 1 Publications Verification
Taurine-d₄ is the deuterium labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes .

HY-W654342

Spermine-d20
Spermine-d₂₀ (NSC 268508-d₂₀) is deuterium labeled Spermine. Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects .

HY-N0091S5

Hypoxanthine-d4
Hypoxanthine-d₄ is the deuterium labeled Hypoxanthine . Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia .

HY-Y0366S

Lauric acid-13C
Lauric acid- ¹³C is the ¹³C labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-W017018S2

L-Ornithine-1,2,3,4,5-13C5 hydrochloride
L-Ornithine-1,2,3,4,5- ¹³C₅ (hydrochloride) is the ¹³C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.

HY-W015913S3

Pyruvic acid-13C-1 sodium
Sodium 2-oxopropanoate- ¹³C is the ¹³C labeled Sodium 2-oxopropanoate . Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .

HY-13342AS

Apatinib-d8 free base

Apatinib-d₈ (free base) is the deuterium labeled Apatinib free base . Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC₅₀=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC₅₀s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ .

HY-N0091S6

Hypoxanthine-d2 1 Publications Verification
Hypoxanthine-d₂ is the deuterium labeled Hypoxanthine . Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia .

HY-N0091S7

Hypoxanthine-15N4 2 Publications Verification
Hypoxanthine- ¹⁵N₄ is the ¹⁵N labeled Hypoxanthine . Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia .

HY-W017018S

L-Ornithine-d6 hydrochloride
L-Ornithine-d₆ (hydrochloride) is the deuterium labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.

HY-W017018S4

L-Ornithine-d7 hydrochloride
L-Ornithine-d₇ (hydrochloride) is the deuterium labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.

HY-113248S

3-Nitro-L-tyrosine-d3
3-Nitro-L-tyrosine-d₃ is the deuterium labeled 3-Nitro-L-tyrosine. 3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions .

HY-W745029A

L-Glutathione reduced-d5 ammonium
L-Glutathione reduced-d₅ (GSH-d₅) ammonium is the deuterium labeled L-Glutathione reduced (HY-D0187). L-Glutathione reduced (GSH) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

HY-B0351S1

Taurine-13C2
Taurine- ¹³C₂ is the ¹³C-labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes .

HY-66011AS

Moxifloxacin-d4
Moxifloxacin-d₄ is the deuterium labeled Moxifloxacin. Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia .

HY-N0091S2

Hypoxanthine-13C5
Hypoxanthine- ¹³C₅ is a ¹³C-labeled Hypoxanthine (HY-N0091). Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

HY-W017018S5

L-Ornithine-15N2 hydrochloride
L-Ornithine- ¹⁵N₂ (hydrochloride) is the ¹⁵N-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.

HY-D0187S4

L-Glutathione reduced-13C
L-Glutathione reduced- ¹³C (GSH- ¹³C; γ-L-Glutamyl-L-cysteinyl-glycine- ¹³C) is ¹³C-labeled L-Glutathione reduced (HY-D0187). L-Glutathione reduced is an endogenous antioxidant and oxygen free radical scavenger.

HY-Y0366S3

Lauric acid-d3
Lauric acid-d₃3 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-Y0366S1

Lauric acid-d23
Lauric acid-d₂₃3 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-11063S

Fingolimod-d4
Fingolimod-d₄ is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC₅₀ of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant .

HY-A0023AS1

Alogliptin-d3
Alogliptin-d₃ is the deuterium labeled Alogliptin. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC₅₀ of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes .

HY-145119S

Mindeudesivir
GS-621763-d₁ is the deuterium labeled GS-621763 (HY-145119) . GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice .

HY-W017018S3

L-Ornithine-d2 hydrochloride
L-Ornithine-d₂ (hydrochloride) is the deuterium labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.

HY-107322AS1

Barnidipine-d5

Barnidipine-d₅ is the deuterium-labeled Barnidipine (HY-107322A). Barnidipine-d₅ (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [ ³H] initrendipine binding sites (K_i=0.21 nmol/l), has selective action against CaA receptors . Barnidipine-d₅ (Mepirodipine) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action .

HY-B1486AS

Oxprenolol-d7
Oxprenolol-d₇ is the deuterium labeled Oxprenolol. Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a K_i of 7.10 nM in a radioligand binding assay using rat heart muscle .

HY-42682S1

D(+)-Galactosamine-13C hydrochloride
D(+)-Galactosamine- ¹³C (hydrochloride) is the ¹³C labeled D(+)-Galactosamine hydrochloride. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and

HY-14566S

Donepezil-d7 hydrochloride
Donepezil-d₇ (hydrochloride) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

HY-B0099S

Edaravone-d5
Edaravone-d₅ is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator .

HY-B0661S

Tamsulosin-d4
Tamsulosin-d₄ ((R)-(-)-YM12617 (free base)-d₄) is deuterium labeled Tamsulosin. Tamsulosin ((R)-(-)-YM12617 free base) is an inhibitor of α₁-adrenergic receptor. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth in animal models .

HY-B0102S

Fluoxetine-d6
Fluoxetine-d₆ (LY-110140 (free base)-d₆) is deuterium labeled Fluoxetine. Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

HY-166341S

*S 8849-1-d4 free* base**
S 8849-1-d₄ (free base) (Tianeptine metabolite MC5-d₄) is deuterium labeled S 8849-1 (free base). S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants .

HY-W142395S

*6-TAMRA-d12 free* acid**
6-TAMRA-d₁₂ free acid is a deuterated-labeled 6-TAMRA, which is widely used in the preparation of fluorescent antibodies and as a fluorescent group for immunohistochemical avidin derivatives.

HY-14566S3

Donepezil-d4
Donepezil-d₄ (E2020-d₄ (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

HY-W727525

Donepezil-d7
Donepezil-d₇ (E2020-d₇ (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

HY-B0690S

Fosinopril-d5
Fosinopril-d₅ (SQ28555-d₅ (free acid)) is deuterium labeled Fosinopril. Fosinopril (SQ28555 free acid) is the ester proagent of angiotensin-converting enzyme (ACE) inhibitor with an IC₅₀ value of 0.18 μM. Fosinopril demonstrates a non-competitive inhibition effect on ACE activity with an K_i value of 1.675 μM .

HY-B0732AS

Itopride-d6

Itopride-d₆ (HSR803-d₆ (free base)) is deuterium labeled Itopride. Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD) .

HY-152852S

*Mefatinib-d6 free* base**
Mefatinib-d6 free base (Mifanertinib-d6) is the deuterium labeled Mefatinib. Mefatinib is a potent tyrosine kinase inhibitor with antineoplastic activity .

HY-16168AS

Degarelix-d7
Degarelix-d₇ (FE 200486-d₇ free base) is deuterium labeled Degarelix. Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.

HY-B0689S1

Indinavir-13C4,15N

Indinavir- ¹³C₄, ¹⁵N (MK-639 (free base)- ¹³C₄, ¹⁵N) is ¹³C and ¹⁵N labeled Indinavir. Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CL ^pro inhibitor .

HY-66011BS

(Rac)-Moxifloxacin-d4

(Rac)-Moxifloxacin-d₄ ((Rac)-BAY 12-8039-d₄ (free base)) is deuterium labeled (Rac)-Moxifloxacin. (Rac)-Moxifloxacin ((Rac)-BAY 12-8039 free base) is the isoform of Moxifloxacin Hydrochloride (HY-66011), which is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia .

HY-B0731AS

Perospirone-d8

Perospirone-d₈ (SM-9018-d₈ (free base)) is deuterium labeled Perospirone. Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT_2A receptor (K_i=0.6 nM) and dopamine D₂ receptor (K_i=1.4 nM), and also a partial agonist of 5-HT_1A receptor (K_i=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research .

HY-W728096

Migalastat-d5

Migalastat-d₅ (GR181413A-d₅ (free base)) is deuterium labeled Migalastat. Migalastat (GR181413A free base) is an orally active α-galactosidase A molecular chaperone, with an IC₅₀ value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity .

HY-14566S1

Donepezil-d5
Donepezil-d₅ is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

HY-B0072S

Tropisetron-d5

Tropisetron-d₅ (SDZ-ICS-930-d₅ (free base)) is deuterium labeled Tropisetron. Tropisetron (SDZ-ICS-930 free base) is an orally active anti-inflammatory and antiemetic agent. Tropisetron is 5-HT₃R antagonists with a K_i of 5.3 nM. Tropisetron is also a partial agonist of α7 nicotinic receptor (α7 nAChR) with an EC₅₀ of 1.3 μM. In addition, Tropisetron has antitumor and neuroprotective effects .

HY-121467S1

Acotiamide-d4

Acotiamide-d₄ (Z-338 (free base)-d₄) is deuterium labeled Acotiamide. Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC₅₀ of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .

HY-13567S1

Bendamustine-d8
Bendamustine-d₈ is the deuterium labeled Bendamustine . Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70069GL

Endo S2, Streptococcus pyogenes (GMP Like)	Biochemical Assay Reagents	Infection
Endo S2, Streptococcus pyogenes (GMP Like) is Endo S2, Streptococcus pyogenes (HY-E70069) produced by using GMP like guidelines. Endo-β-N-acetylglucosaminidase (Endo S2) is a key enzyme involved in the processing of free oligosaccharides in the cytosol. Endo-β-N-acetylglucosaminidase catalyzes hydrolysis of N-linked oligosaccharides .

HY-13271AG

Tubastatin A	HDAC Beta-lactamase Autophagy Apoptosis	Cancer
Tubastatin A (GMP) is the Tubastatin A (HY-13271A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tubastatin A is a potent and selective HDAC6 inhibitor with an IC₅₀ of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).

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