51 Results for "

G2/M+arrest

" in MedChemExpress (MCE) Product Catalog:
Products (51)

51 Results for "G2/M+arrest" in MCE Product Catalog:

172
Decitabine
Decitabine
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172 Publications Verification
Art. -Nr.: HY-A0004
CAS. Nr.: 2353-33-5
Synonyms: 5-Aza-2'-deoxycytidine; 5-AZA-CdR; NSC 127716
Target:  

DNA Methyltransferase Apoptosis Nucleoside Antimetabolite/Analog

Forschungsgebiete:  

Infection Inflammation/Immunology Cancer

Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell Apoptosis. Decitabine has potent anticancer activity .
6
Rigosertib
Rigosertib
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6 Cited Publications
Art. -Nr.: HY-12037A
CAS. Nr.: 592542-59-1
Reinheit:  99.01%
Synonyms: ON-01910
Target:  

Polo-like Kinase (PLK) PI3K Apoptosis Raf

Forschungsgebiete:  

Cancer

Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle . Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM .
6
Rigosertib sodium
Rigosertib sodium
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6 Cited Publications
Art. -Nr.: HY-12037
CAS. Nr.: 592542-60-4
Reinheit:  99.57%
Synonyms: ON-01910 sodium
Target:  

Polo-like Kinase (PLK) PI3K Apoptosis

Forschungsgebiete:  

Neurological Disease Inflammation/Immunology Cancer

Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle . Rigosertib sodium is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM .
2
Oxcarbazepine
Oxcarbazepine
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2 Cited Publications
Art. -Nr.: HY-B0114
CAS. Nr.: 28721-07-5
Synonyms: GP 47680
Target:  

Sodium Channel Apoptosis

Forschungsgebiete:  

Neurological Disease Cancer

Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Anti-cancer and anticonvulsant effects .
2
TZ9
TZ9
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2 Cited Publications
Art. -Nr.: HY-18643
CAS. Nr.: 1002789-86-7
Target:  

E1/E2/E3 Enzyme Apoptosis

Forschungsgebiete:  

Cancer

TZ9 is a selective Rad6 inhibitor. TZ9 inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2-M arrest and apoptosis, and inhibits the proliferation and migration of metastatic human breast cancer cells .
2
Chelidonine
Chelidonine
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2 Cited Publications
Art. -Nr.: HY-N2369
CAS. Nr.: 476-32-4
Category:  

Infection Alkaloids Chelidonium majus Plants Disease Research Fields Isoquinoline Alkaloids Papaveraceae

Target:  

Apoptosis Influenza Virus

Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity .
1
HA-9104
HA-9104
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1 Cited Publications
Art. -Nr.: HY-160799
CAS. Nr.: 2412367-83-8
Target:  

E1/E2/E3 Enzyme Apoptosis

Forschungsgebiete:  

Cancer

HA-9104 is a potent and selective inhibitor of cullin-5 neddylation via virtually targeting the V30 pocket of UBE2F. HA-9104 binds to UBE2F, reduces its protein levels, and consequently inhibits cullin-5 neddylation. HA-9104 has potent growth suppression and radiosensitizing activities via targeting the UBE2F-CRL5 axis and causing DNA damage, leading to induction of apoptosis and G2/M arrest in lung and pancreatic cancer cells .
1
CAM833
CAM833
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1 Cited Publications
Art. -Nr.: HY-150147
CAS. Nr.: 2758364-02-0
Reinheit:  99.83%
Target:  

RAD51 Apoptosis

Forschungsgebiete:  

Cancer

CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization. CAM833 increases the progression of G2/M-arrested cells into apoptosis .
ABBV-706
ABBV-706
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Art. -Nr.: HY-170554
ABBV-706 is a SEZ6-targeted topoisomerase 1 inhibitor Antibody-Drug Conjugates (ADCs), which is composed of the Linker-Payload conjugation (HY-148820) and the Anti-SEZ6 Antibody (SC17) (HY-P991041). ABBV-706 can inhibit cancer cells proliferation and induce DNA damage and G2/M arrest. ABBV-706 exhibits high efficacy against small cell lung cancer (SCLC), neuroendocrine tumors (NENs) and central nervous system (CNS) tumors .
1-Monopalmitin
1-Monopalmitin
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Art. -Nr.: HY-W009141
CAS. Nr.: 542-44-9
Synonyms: Glyceryl palmitate
Category:  

Plants

Target:  

P-glycoprotein IAP PI3K Akt Caspase Apoptosis

1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting IAPs protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC50=50-58 μg/mL), with low toxicity to normal cells .
Tinengotinib
Tinengotinib
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Art. -Nr.: HY-145601
CAS. Nr.: 2230490-29-4
Reinheit:  98.45%
Synonyms: TT 00420
Target:  

Aurora Kinase FGFR VEGFR

Forschungsgebiete:  

Cancer

Tinengotinib (TT00420) is an orally active, spectrally selective small molecule kinase inhibitor targeting Aurora A/B (IC50=1.2-3.3 nM), FGFR1/2/3 (IC50=1.5-3.5 nM), VEGFRs, JAK1/2 and CSF1R. Tinengotinib blocks Aurora kinase-mediated cell cycle progression (inducing G2/M arrest), inhibits FGFR/JNK-JUN signaling pathway and activates MEK/ERK-dependent apoptotic pathway. Tinengotinib has the activity of anti-tumor proliferation, inducing apoptosis, inhibiting angiogenesis and regulating tumor microenvironment. Tinengotinib can be used in the study of triple-negative breast cancer (TNBC), gallbladder cancer and tumor immune microenvironment .
(-)-Pinoresinol
(-)-Pinoresinol
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Art. -Nr.: HY-126067
CAS. Nr.: 81446-29-9
Category:  

other families Hernandia nymphaeifolia (C. Presl) Kubitzki Lignans Phenylpropanoids Plants

Target:  

Glycosidase Apoptosis

(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that inhibits α-glucosidase and acts as a hypoglycemic agent. (-)-Pinoresinol has some anti-inflammatory effects and acts as a chemopreventive agent, inducing increased apoptosis and cell cycle G2/M arrest .
Maytansinoid B
Maytansinoid B
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Art. -Nr.: HY-148870
CAS. Nr.: 1628543-40-7
Reinheit:  95.48%
Target:  

ADC Payloads

Forschungsgebiete:  

Cancer

Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form antibody-drug conjugates (ADCs). Maytansinoids are known as antimitotic agents, binding to tubulin and inhibiting microtubule assembly. Maytansinoids induces G2/M arrest in the cell cycle to induce apoptosis .
Decitabine (Standard)
Decitabine (Standard)
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Art. -Nr.: HY-A0004R
CAS. Nr.: 2353-33-5
Synonyms: 5-Aza-2'-deoxycytidine (Standard); 5-AZA-CdR (Standard); NSC 127716 (Standard)
Target:  

Reference Standards DNA Methyltransferase Apoptosis Nucleoside Antimetabolite/Analog

Forschungsgebiete:  

Cancer

Decitabine (Standard) is the analytical standard of Decitabine. This product is intended for research and analytical applications. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .
9-Methoxycamptothecin
9-Methoxycamptothecin
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Art. -Nr.: HY-N6011
CAS. Nr.: 39026-92-1
Category:  

Alkaloids Pyridine Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields Isoquinoline Alkaloids Cancer

Target:  

Topoisomerase Apoptosis

9-Methoxycamptothecin (MCPT), isolated from Camptotheca acuminata, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer .
Ovatodiolide
Ovatodiolide
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Art. -Nr.: HY-118921
CAS. Nr.: 3484-37-5
Category:  

Labiatae Terpenoids Diterpenoids Plants Artemisia persica Boiss.

Target:  

Apoptosis

Ovatodiolide is a compound that can be isolated from Anisomeles indica. Ovatodiolide has anti-bacterial and anti-inflammatory properties. Ovatodiolide also has anti-cancer activity that induces cell cycle G2/M arrest and apoptosis via a ROS-dependent ATM/ATR signaling pathways .
Simmiparib
Simmiparib
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Art. -Nr.: HY-115552
CAS. Nr.: 1551355-46-4
Reinheit:  99.01%
Target:  

PARP

Forschungsgebiete:  

Cancer

Simmiparib is a highly potent and orally active PARP1 and PARP2 inhibitor with IC50 values of 1.75 nM and 0.22 nM, respectively. Simmiparib has more potent PARP1/2 inhibition than its parent Olaparib (HY-10162). Simmiparib induces DNA double-strand breaks (DSB) accumulation and G2/M arrest in homologous recombination repair (HR)-deficient cells, thereby inducing apoptosis. Simmiparib exhibits remarkable anticancer activities in cells and nude mice bearing xenografts .
RGN6024
RGN6024
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Art. -Nr.: HY-176537
CAS. Nr.: 3055038-20-2
Target:  

Microtubule/Tubulin

Forschungsgebiete:  

Cancer

RGN6024 is a brain-penetrant, orally active and reversible small molecule tubulin destabilizer. RGN6024 inhibits microtubule polymerization both in biochemical and cellular assays, binds to the colchicine binding pocket of β-tubulin (SPR: Kd = 6.7 μM; tryptophan assay: Kd = 7.4 μM), and triggers G2/M arrest in glioblastoma (GB) cells. RGN6024 retains activity in βIII-tubulin overexpressing cells. RGN6024 inhibits tumor growth in a GB xenograft mouse model. RGN6024 can be used for the study of glioblastoma (GB) .
HQY1428
HQY1428
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Art. -Nr.: HY-172970
CAS. Nr.: 3093763-71-1
Target:  

CDK DNA/RNA Synthesis Apoptosis

Forschungsgebiete:  

Cancer

HQY1428 is an orally active CDK12 inhibitor. HQY1428 inhibits DNA replication, causes G2/M arrest in SKOV3 cells, induces DNA double-strand breaks and apoptosis. HQY1428 has anti-tumor activity in the SKOV3 xenograft mouse model. HQY1428 combined with the HER2 inhibitor Lapatinib (HY-50898) in the NCI-N87 xenograft mouse model produces a synergistic therapeutic effect .
MASTL/Aurora A-IN-1
MASTL/Aurora A-IN-1
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Art. -Nr.: HY-W231513
CAS. Nr.: 321945-24-8
Target:  

MASTL Ser/Thr Protease Aurora Kinase

Forschungsgebiete:  

Cancer

MASTL/Aurora A-IN-1 (Compound MA4) is a dual inhibitor of MASTL and Aurora A kinases with IC50 values of 0.56 μM and 0.16 μM, respectively. MASTL/Aurora A-IN-1 has broad-spectrum anticancer activity and has potent anticancer activity against SR (leukemia), K-562 (leukemia), MDA-MB-435 (melanoma), MOLT-4 (leukemia), and SK-MEL-2 (melanoma) cell lines in NCI-60 cancer cell lines with GI50 values of 0.023, 0.032, 0.037, 0.044, and 0.051 μM, respectively. MASTL/Aurora A-IN-1 inhibits Aurora A and MASTL kinases, inducing cell cycle G2/M arrest, thereby inhibiting cancer cell proliferation. MASTL/Aurora A-IN-1 can be used in cancer research, especially for tumors with dysregulated mitosis .
Assay Types