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GAT-3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino acid Transporter (1) Apoptosis (1) Caspase (1) CDK (1) Creatine Kinase (1) GABA Receptor (15) PARP (1) Reference Standards (2) Small Interfering RNA (siRNA) (5)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (14)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (3) siRNAs (5)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0696

Tiagabine NO050328; NO328; TGB	GABA Receptor	Neurological Disease
Tiagabine (NO050328; NO328; TGB) is an orally active, highly selective, and reversible *GAT-1* inhibitor and anticonvulsant that crosses the blood-brain barrier. By blocking the reuptake of GABA in neurons and glial cells, tiagabine increases extracellular GABA levels to enhance inhibitory signal transduction, thereby exerting multiple activities such as anticonvulsant, neuroprotective, and antioxidant effects. Tiagabine exhibits linear pharmacokinetic properties. Although it is metabolized by *CYP3A* and has a high protein binding rate, it carries a low risk of cognitive impairment. Tiagabine is widely used in research on related diseases including epilepsy (including refractory partial seizures), alcohol withdrawal symptoms, and Huntington's disease ^[3] .

HY-100228A

SKF89976A hydrochloride d,l-SKF89976A hydrochloride	GABA Receptor	Neurological Disease
SKF89976A hydrochloride is a selective GABA transporter (GAT-1) inhibitor with IC₅₀s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.

HY-100809

Guvacine hydrochloride 1 Publications Verification	GABA Receptor	Neurological Disease
Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC₅₀s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).

HY-N2482A

Guvacine hydrobromide 1 Publications Verification	GABA Receptor	Neurological Disease
Guvacine hydrobromide, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine hydrobromide inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC₅₀ values of 39 μM, 58 μM and 378 μM, respectively .

HY-103534

CI-966 hydrochloride	GABA Receptor	Neurological Disease
CI-966 hydrochloride is a potent, selective, orally active and brain-penetrant inhibitor of the GABA transporter *GAT-1, with IC₅₀s of 0.26 μM and 1.2 μM for hGAT-1, rGAT-1, respectively. CI-966 hydrochloride shows more than 200-fold selectivity over GAT-2, GAT-3, and BGT*-3. CI-966 hydrochloride exhibits anticonvulsant and neuroprotective activities ^[3].

HY-N2482

Guvacine	GABA Receptor	Neurological Disease
Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC₅₀ values of 39 μM, 58 μM and 378 μM, respectively .

HY-124285

ATPCA hydrochloride	GABA Receptor	Others
ATPCA hydrochloride is a selective radioactive substrate for BGT1 over GAT1/GAT3 .

HY-177796

TMLB-C16	Apoptosis CDK Caspase PARP	Cancer
TMLB-C16 is a potent and orally active *B3GAT3* inhibitor with a K_D of 3.962 μM. TMLB-C16 suppresses proliferation and migration, and induces cell cycle arrest and apoptosis in MHCC-97H (IC₅₀ = 6.53 μM) and HCCLM3 cells (IC₅₀ = 6.22 μM). TMLB-C16 inhibits tumor growth in both MHCC-97H and HCCLM3 xenograft tumor mouse models without causing obvious toxicity. TMLB-C16 can be used for hepatocellular carcinoma research .

HY-100228

SKF 89976A	GABA Receptor	Neurological Disease
SKF89976A is a selective GABA transporter (GAT-1) inhibitor with IC₅₀s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.

HY-RS25183

B3gat3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
B3gat3 Rat Pre-designed siRNA Set A contains three designed siRNAs for B3gat3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

B3gat3 Rat Pre-designed siRNA Set A B3gat3 Rat Pre-designed siRNA Set A

HY-RS01308

B3GAT3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
B3GAT3 Human Pre-designed siRNA Set A contains three designed siRNAs for B3GAT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

B3GAT3 Human Pre-designed siRNA Set A B3GAT3 Human Pre-designed siRNA Set A

HY-123240

CI-966	GABA Receptor	Neurological Disease
CI-966 is a potent, selective, orally active and brain-penetrant inhibitor of the GABA transporter *GAT-1, with IC₅₀s of 0.26 μM and 1.2 μM for hGAT-1, rGAT-1, respectively. CI-966 shows more than 200-fold selectivity over GAT-2, GAT-3, and BGT*-3. CI-966 exhibits anticonvulsant and neuroprotective activities ^[3].

HY-RS13297

SLC6A11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SLC6A11 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC6A11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLC6A11 Human Pre-designed siRNA Set A SLC6A11 Human Pre-designed siRNA Set A

HY-RS13299

SLC6A13 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SLC6A13 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC6A13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLC6A13 Human Pre-designed siRNA Set A SLC6A13 Human Pre-designed siRNA Set A

HY-182944

GATT-44	GABA Receptor	Neurological Disease
GATT-44 is a blood-brain barrier-permeable, selective GABA transporter 1 (GAT-1) ligand with an IC₅₀ of 126 nM. GATT-44 shows selectivity for GAT-2, GAT-3 and BGT-1 subtypes, and undergoes copper-mediated ¹⁸F-radiofluorination. The radiolabeled GATT-44 ([ ¹⁸F]GATT-44) exhibits brain uptake, metabolic stability and high GAT-1 binding specificity in non-human primates. GATT-44 is applicable for research on neurodegenerative and neuropsychiatric diseases .

HY-RS18696

B3gat3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
B3gat3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for B3gat3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

B3gat3 Mouse Pre-designed siRNA Set A B3gat3 Mouse Pre-designed siRNA Set A

HY-100228AR

SKF89976A hydrochloride (Standard) d,l-SKF89976A hydrochloride (Standard)	GABA Receptor Reference Standards	Neurological Disease
SKF89976A (hydrochloride) (Standard) is the analytical standard of SKF89976A (hydrochloride) (HY-100228A). This product is intended for research and analytical applications. SKF89976A hydrochloride is a selective GABA transporter (GAT-1) inhibitor with IC50s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.

HY-W033027

BGT1-IN-1	GABA Receptor	Neurological Disease
BGT1-IN-1 (compound 9) is a potent BGT1 inhibitor with IC₅₀ value of 13.9, 58.3 µM for hBGT1, GAT3, respectively. BGT1-IN-1 shows no cytotoxic. BGT1-IN-1 shows neuroprotective activity .

HY-181961

SR-THAP	GABA Receptor	Cardiovascular Disease Neurological Disease
SR-THAP is a γ-aminobutyric acid transporter 3 (GAT3) inhibitor with an IC₅₀ of 4.9 μM, and exhibits 42-fold and 23-fold selectivity over GAT1 and GlyT1, respectively. SR-THAP inhibits GABA uptake in mammalian cells. SR-THAP is applicable to the research of epilepsy, Alzheimer's disease and ischemic stroke .

HY-103534R

CI-966 hydrochloride (Standard)	Reference Standards GABA Receptor	Neurological Disease
CI-966 hydrochloride (Standard) is the analytical standard of CI-966 hydrochloride (HY-103534). This product is intended for research and analytical applications. CI-966 hydrochloride is a potent, selective, orally active and brain-penetrant inhibitor of the GABA transporter GAT-1, with IC₅₀s of 0.26 μM and 1.2 μM for hGAT-1, rGAT-1, respectively. CI-966 hydrochloride shows more than 200-fold selectivity over GAT-2, GAT-3, and BGT-3. CI-966 hydrochloride exhibits anticonvulsant and neuroprotective activities ^[3].

HY-181135

Bicyclo-GABA	GABA Receptor	Neurological Disease
Bicyclo-GABA is a selective betaine/GABA transporter 1 (BGT1) competitive, non-transported inhibitor with an IC₅₀ of 590 nM. Bicyclo-GABA exhibits low micromolar agonistic activity at α₁β₂γ₂ GABA_A receptors with an EC₅₀ of 5.1 μM. Bicyclo-GABA displays 129 times higher activity for BGT1 than GAT3. Bicyclo-GABA serves as a valuable tool compound for deciphering its elusive pharmacological role in the brain and periphery .

HY-181753

INSP-0154	Creatine Kinase Amino acid Transporter	Inflammation/Immunology Cancer
INSP-0154 is a potent creatine kinase B (CKB)/creatine transporter (SLC6A8) inhibitor. INSP-0154 binds to the SLC6A8 occluded pocket, prevents creatine transport into cells, and protects SLC6A8 cysteine residue C144 from irreversible inactivation. INSP-0154 inhibits creatine uptake in mouse heart tissue. INSP-0154 can be used for the research of cancer .

Guvacine hydrochloride 1 Publications Verification	Alkaloids Neurological Disease Classification of Application Fields Areca catechu L. Pyridine Alkaloids Palmae Plants Disease Research Fields Source Classification	GABA Receptor
Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC₅₀s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).

Guvacine	Alkaloids Areca catechu L. Pyridine Alkaloids Plants Palmae Source Classification	GABA Receptor
Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC₅₀ values of 39 μM, 58 μM and 378 μM, respectively .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P7626

	B3GAT3 Protein, Human (His) rHuB3GAT3, His; B3GAT3; Beta-1,3-Glucuronyltransferase 3;	Human	E. coli
	B3GAT3 Protein, Human (His), a recombinant human B3GAT3 produced in E. coli, has a His tag. B3GAT3, a member of the glucuronyltransferase gene family, exhibits strict acceptor specificity.

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B3gat3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
B3gat3 Rat Pre-designed siRNA Set A contains three designed siRNAs for B3gat3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

B3GAT3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
B3GAT3 Human Pre-designed siRNA Set A contains three designed siRNAs for B3GAT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLC6A11 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SLC6A11 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC6A11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLC6A13 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SLC6A13 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC6A13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

B3gat3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
B3gat3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for B3gat3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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