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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
HPGDS
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "HPGDS" in MCE Product Catalog:
3
3 Cited Publications
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hPGDS-IN-1 (Compound 2 ) is an hPGDS inhibitor with an IC50 of 12 nM (as measured by fluorescence polarization assay or EIA). hPGDS-IN-1 can be used in the research of allergic rhinitis and spinal cord neurons .
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HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX .
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HQL-79, a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS .
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HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC50 of 9.9 nM .
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PROTAC(H-PGDS)-7 is a Hematopoietic prostaglandin D synthase (H-PGDS) molecular glue degrader, with a DC50 of 17.3 pM .
Cat. No.: HY-146662
CAS No.: 2255311-93-2
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HPGDS inhibitor 3 is an orally active and highly potent peripherally restricted hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 value of 9.4 nM and EC50 of 42 nM, respectively. HPGDS inhibitor 3 exhibits good selectivity, good pharmacokinetic parameters in mouse, rat, and dog, and no CNS toxicity. HPGDS inhibitor 3 has anti-inflammatory activity .
Cat. No.: HY-120581
CAS No.: 1537192-31-6
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ML388 is a potent and selective hydroxyprostaglandin dehydrogenase (HPGD) inhibitor with an IC50 of 34 nM. ML388 induces PGE2 production in A549 cells and LNCaP prostate cancer cells .
Cat. No.: HY-RS17229
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Hpgds Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hpgds gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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TFC-007, a selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, show high inhibitory activity against H-PGDS enzyme (IC50 value of 83 nM). TFC-007 can be used for composing H-PGDS degradation inducer PROTAC(H-PGDS)-1 (TFC-007 binds to H-PGDS, and Pomalidomide binds to cereblon) .
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F092 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS) with a KD value of 0.14 nM. F092 can be used in the study of allergic and inflammatory responses .
Cat. No.: HY-RS06341
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HPGDS Human Pre-designed siRNA Set A contains three designed siRNAs for HPGDS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-10439R
CAS No.: 1033836-12-2
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HPGDS inhibitor 1 (Standard) is the analytical standard of HPGDS inhibitor 1 (HY-10439). This product is intended for research and analytical applications. HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX .
Cat. No.: HY-157577
CAS No.: 2761281-51-8
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PROTAC (H-PGDS)-8 is an H-PGDS PROTAC inhibitor with a IC50 of 0.14 μM. PROTAC (H-PGDS)-8 binds to H-PGDS and inhibits its enzymatic activity. PROTAC (H-PGDS)-8 inhibits the production of PGD2 in cancer cells. PROTAC (H-PGDS)-8 can be used for the research of Duchenne muscular dystrophy .
Cat. No.: HY-RS06338
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HPGD Human Pre-designed siRNA Set A contains three designed siRNAs for HPGD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06339
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Hpgd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hpgd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06340
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Hpgd Rat Pre-designed siRNA Set A contains three designed siRNAs for Hpgd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23682
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Hpgds Rat Pre-designed siRNA Set A contains three designed siRNAs for Hpgds gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P71036
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HPGDS; H-PGDS; Hematopoietic Prostaglandin D Synthase; GSTS1; GSTS; PGD2; PGDS; Glutathione S-Transferase Sigma; Glutathione-Requiring Prostaglandin D Synthase; Glutathione S-Transferase; Glutathione-Dependent PGD Synthase; Epididymis Secretory Sperm Bind
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2-Benzoylthiophene is an inhibitor of human hematopoietic prostaglandin D2 synthase (H-PGDS) with an IC50 value of 11.4 μM. 2-Benzoylthiophene can be used in the research of inflammatory diseases .
Cat. No.: HY-108259R
CAS No.: 162641-16-9
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HQL-79 (Standard) is the analytical standard of HQL-79 (HY-108259). This product is intended for research and analytical applications. HQL-79, a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
