2255311-93-2
Chemical Structure
HPGDS inhibitor 3
- CAS No.: 2255311-93-2
- Formula:C21H27N3O2
- Molecular Weight:353.46
IUPAC Name: 7-cyclopropyl-N-((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-1,8-naphthyridine-3-carboxamide
InChIKey: VEKOTFOGNGVLSE-QAQDUYKDSA-N
SMILES: CC(O)([C@H]1CC[C@@H](CC1)NC(C2=CC3=CC=C(N=C3N=C2)C4CC4)=O)C
Biological Activity: HPGDS inhibitor 3 is an orally active and highly potent peripherally restricted hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 value of 9.4 nM and EC50 of 42 nM, respectively. HPGDS inhibitor 3 exhibits good selectivity, good pharmacokinetic parameters in mouse, rat, and dog, and no CNS toxicity. HPGDS inhibitor 3 has anti-inflammatory activity[1].
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HPGDS inhibitor 3 | HPGDS inhibitor 3 is an orally active and highly potent peripherally restricted hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 value of 9.4 nM and EC50 of 42 nM, respectively. HPGDS inhibitor 3 exhibits good selectivity, good pharmacokinetic parameters in mouse, rat, and dog, and no CNS toxicity. HPGDS inhibitor 3 has anti-inflammatory activity. | |||||||||||||||||||||
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Keywords
