280 Results for "

IgG4

" in MedChemExpress (MCE) Product Catalog:

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Pembrolizumab

35 Publications Verification

Cat. No.: HY-P9902

CAS No.: 1374853-91-4

Synonyms: MK-3475; Lambrolizumab

Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy.

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Pembrolizumab (anti-PD-1)

35 Publications Verification

Cat. No.: HY-P9902A

Synonyms: MK-3475 (anti-PD-1); Lambrolizumab (anti-PD-1)

Pembrolizumab (anti-PD-1) is a humanized IgG4 antibody and PD-1 inhibitor. Pembrolizumab produces PD-1 blockade, preventing PD-L1 and PD-L2 from connecting to PD-1. This avoids the uncontrolled regulation of T cells on cells that normally express PD-1 .

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Nivolumab

24 Cited Publications

Cat. No.: HY-P9903

CAS No.: 946414-94-4

Synonyms: BMS-936558; ONO-4538; MDX-1106

Nivolumab is a programmed death receptor-1 (PD-1) blocking human IgG4 antibody to treat advanced (metastatic) non-small cell lung cancer.

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Human IgG4 (S228P) kappa, Isotype Control

11 Cited Publications

Cat. No.: HY-P99003

Human IgG4 (S228P) kappa, Isotype Control, a human-derived monoclonal antibody, is an isotype control for human IgG4κ antibody.

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Magrolimab

5 Cited Publications

Cat. No.: HY-P99029

CAS No.: 2169232-81-7

Synonyms: Hu5F9-G4

Magrolimab (Hu5F9-G4) is a humanized anti-CD47 antibody. Magrolimab, an IgG4 isotype, lacks ADCC function and exhibits relatively weak ADCP effector function. Magrolimab can be used for the study of malignant bone tumors and breast cancer .

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Tanruprubart

5 Cited Publications

Cat. No.: HY-P990545

CAS No.: 2065212-40-8

Synonyms: ANX005

Tanruprubart (ANX005) is a C1q inhibitor and C1q depleter. Tanruprubart is a human antibody expressed in CHO cells, with huIgG1 heavy chains and huκ light chains, and its predicted molecular weight (MW) is 145 kDa. For the isotype control of Tanruprubart, refer to Human IgG4 kappa, Isotype Control (HY-P99003). The IC₅₀ of Tanruprubart is 346 ng/mL for humans and 259 ng/mL for rats; its EC₅₀ is 3.8 ng/mL for humans, 5.2 ng/mL for rats, and 9.9 ng/mL for mice. Tanruprubart is applicable to the research of Guillain-Barré syndrome and Alzheimer's disease .

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Camrelizumab

4 Cited Publications

Cat. No.: HY-P9971

CAS No.: 1798286-48-2

Synonyms: SHR-1210; INCSHR1210

Camrelizumab (SHR-1210) is a potent humanied high-affinity IgG4-κ monoclonal antibody (mAb) to PD-1. Camrelizumab binds PD-1 at a high affinity of 3 nM and inhibits the binding interaction of PD-1 and PD-L1 with an IC₅₀ of 0.70 nM. Camrelizumab acts as anti-PD-1/PD-L1 agent and can be used for cancer research, including NSCLC, ESCC, Hodgkin lymphoma, and advanced HCC et,al .

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ATG-031

4 Cited Publications

Cat. No.: HY-P99176

ATG-031 is a humanized anti-CD24 monoclonal antibody with high affinity and specificity. ATG-031 interacts with Siglec-10 expressed by tumor-associated macrophages. ATG-031 effectively stimulates macrophage-mediated phagocytosis and induces cancer cell destruction by blocking the anti-phagocytic surface proteins. ATG-031 can be used in the study of haematological malignancies as well as solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

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Metelimumab

3 Cited Publications

Cat. No.: HY-P99305

CAS No.: 272780-74-2

Synonyms: CAT-192; Anti-TGFB1 Recombinant Antibody

Metelimumab (CAT-192) is a human IgG4 monoclonal antibody that can selectively neutralize TGFβ1 .

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Sintilimab

3 Cited Publications

Cat. No.: HY-P99048

CAS No.: 2072873-06-2

Synonyms: IBI308

Sintilimab (IBI308) is a safe and effectivel humanized IgG4 monoclonal antibody that binds to PD-1 with a K_D value of 74 pM. Sintilimab blocks the interaction of PD-1 with its ligands (PD-L1 and PL-L2), consequently helping to restore the endogenous antitumour T-cell response. Sintilimab combined with prebiotics inhibits tumor volume and regulates immune cell subpopulation balance in lung adenocarcinoma mice. Sintilimab can be used for the research of classical Hodgkin's lymphoma, non-small cell lung cancer and oesophageal cancer ^[4] .

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Ixekizumab

3 Cited Publications

Cat. No.: HY-P9924

CAS No.: 1143503-69-8

Synonyms: LY2439821

Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A (K_D<3 pM). Ixekizumab directly blocks IL-17A binding to IL-17RA (IL-17A receptor) but does not bind to other IL-17 family members. Ixekizumab is used for the research of moderate-to-severe plaque psoriasis .

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Natalizumab (Anti-CD49d)

3 Cited Publications

Cat. No.: HY-108831A

CAS No.: 189261-10-7

Purity: 98.72%

Synonyms: AN100226; BG00002

Natalizumab (Anti-CD49d) (AN100226; BG00002) Solution is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d), blocking the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab solution inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 ⁺ T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thereby exerting anti-inflammatory and immunomodulatory activity. Natalizumab (Anti-CD49d) solution is used in the study of relapsing-remitting multiple sclerosis (RRMS) and is also applied in the research of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab (Anti-CD49d) can also prevent lymphocytes from entering the central nervous system, thus preventing acute demyelinating relapses ^[4] .

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Natalizumab

3 Cited Publications

Cat. No.: HY-108831

CAS No.: 189261-10-7

Purity: 99.10%

Natalizumab (AN100226; BG00002) is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d). It blocks the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 ⁺ T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thus exerting anti-inflammatory and immunomodulatory activity. Natalizumab is used in the study of relapsing-remitting multiple sclerosis (RRMS) and also has applications in the study of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab can also prevent lymphocytes from entering the central nervous system, thereby preventing acute demyelinating relapses ^[4] .

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Visugromab

2 Cited Publications

Cat. No.: HY-P99100

CAS No.: 2556646-63-8

Synonyms: CTL-002

Visugromab (CTL-002) is a GDF-15 neutralizing IgG4 mAb. Visugromab has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

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Garadacimab

2 Cited Publications

Cat. No.: HY-P99631

CAS No.: 2162134-62-3

Synonyms: CSL312

Garadacimab (CSL312) is a first-in-class, fully human IgG4 monoclonal antibody targeting activated factor XII (FXIIa). Garadacimab has the potential for hereditary angioedema research .

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Tralokinumab

2 Cited Publications

Cat. No.: HY-P99053

CAS No.: 1044515-88-9

Synonyms: CAT354

Tralokinumab (CAT354) is a humanized IgG4 monoclonal antibody that specifically binds to and neutralizes IL-13. Tralokinumab can be used in the research of diseases such as asthma, atopic dermatitis, and pulmonary fibrosis .

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Volociximab

2 Cited Publications

Cat. No.: HY-P99333

CAS No.: 558480-40-3

Synonyms: M200; Eos 200-4

Volociximab (M200) is a chimeric human/murine IgG4 antibody IIA1 targeting integrin α5β1 (EC₅₀=0.2 nM). Integrin α5β1 is a major fibronectin receptor involved in angiogenesis. Volociximab has antiangiogenic and antitumor activities and inhibits the proliferation of human umbilical vein vascular endothelial cells (HUVECs) .

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Atibuclimab

2 Cited Publications

Cat. No.: HY-P99008

CAS No.: 2417175-94-9

Synonyms: IC14

Atibuclimab (IC14), is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab attenuates Lipopolysaccharides (HY-D1056) (LPS)-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist. Atibuclimab can be used for the research of amyotrophic lateral sclerosis, sepsis, community-acquired pneumonia, or acute lung injury .

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CD64 Protein, Human (HEK293, His)

2 Cited Publications

Cat. No.: HY-P70669

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: Ig gamma-4 chain C region,IgG4 Fc

Species:

Human

Source:

HEK293

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Urelumab

1 Cited Publications

Cat. No.: HY-P99055

CAS No.: 934823-49-1

Urelumab, a fully human, non-ligand binding, CD137 agonist IgG4 monoclonal antibody, enhances T-cell and natural killer-cell antitumor activity, and may enhance cytotoxic activity of Rituximab (HY-P9913). Urelumab can be used for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and other types of non-Hodgkin lymphoma (NHL) .

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