Klotho

By Targets:	Endogenous Metabolite (1) ERK (2) FGFR (4) p38 MAPK (2) TGF-beta/Smad (2)
By Research Areas:	Inflammation/Immunology (5) Metabolic Disease (7)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990964

Efimosfermin alfa BOS-580; LLF580	FGFR	Metabolic Disease Inflammation/Immunology
Efimosfermin alfa is a genetically engineered FGF21 variant. Efimosfermin alfa exerts its function by activating the FGFR1c/β-Klotho complex. Efimosfermin alfa is applicable to researches on metabolic dysfunction-associated steatohepatitis, obesity and mild hypertriglyceridemia .

HY-P99614

Fazpilodemab BFKB8488A; RG-7992; RO-7040551	FGFR	Metabolic Disease
Fazpilodemab (BFKB8488A) is a humanized bispecific IgG1 antibody that selectively targets and activates fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. Fazpilodemab can be used for the research of type 2 diabetes mellitus (T2DM) or nonalcoholic fatty liver disease (NAFLD) .

HY-150687

ZINC12409120	ERK	Metabolic Disease
ZINC12409120 is a high selective ERK inhibitor. ZINC12409120 acts on disrupting *FGF23:α-Klotho* interaction to inhibit ERK activity with an IC₅₀ of 5.0 μM .

HY-P10414A

Klotho-derived peptide 1 hydrochloride KP1 (human) hydrochloride	TGF-beta/Smad p38 MAPK	Inflammation/Immunology
Klotho-derived peptide 1 (KP1 human) hydrochloride blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced activation of Smad2/3 and mitogen-activated protein kinase (MAPK), and exhibits anti-fibrotic and kidney protective effects in mouse model .

HY-P10414

Klotho-derived peptide 1 KP1 (human)	TGF-beta/Smad p38 MAPK	Inflammation/Immunology
Klotho-derived peptide 1 (KP1 human) blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced activation of Smad2/3 and mitogen-activated protein kinase (MAPK), and exhibits anti-fibrotic and kidney protective effects in mouse model .

HY-137321

Estriol 3-glucuronide sodium salt Estriol 3-β-D-Glucuronide sodium salt	Endogenous Metabolite	Metabolic Disease
Estriol 3-glucuronide (Estriol 3-β-D-Glucuronide) sodium salt is a metabolite of Estriol. Estriol 3-glucuronide sodium salt competitively inhibits the hydrolysis of 4-methylumbelliferyl-β-D-glucuronide (4Mu-GlcU). Estriol 3-glucuronide sodium salt is a substrate for hydrolysis by Klotho-human IgG1 Fc protein (KLFc) .

HY-P992195

*Anti-Beta Klotho* Antibody**	FGFR	Inflammation/Immunology
Anti-Beta Klotho Antibody is a monoclonal antibody targeting Beta Klotho*. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Beta Klotho* Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).

HY-186173

MD-3-A45	ERK FGFR	Metabolic Disease
MD-3-A45 is an inhibitor of fibroblast growth factor 23 (FGF-23). MD-3-A45 blocks the activation of the *FGFRs/α-klotho* signaling pathway by FGF-23 and inhibits FGF-23-induced ERK activation. MD-3-A45 can be used in the research of chronic kidney disease, hereditary hypophosphatemic rickets and acquired hypophosphatemic rickets .

Cat. No.	Product Name	Target	Research Area

HY-P10414A

Klotho-derived peptide 1 hydrochloride KP1 (human) hydrochloride	TGF-beta/Smad p38 MAPK	Inflammation/Immunology
Klotho-derived peptide 1 (KP1 human) hydrochloride blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced activation of Smad2/3 and mitogen-activated protein kinase (MAPK), and exhibits anti-fibrotic and kidney protective effects in mouse model .

HY-P10414

Klotho-derived peptide 1 KP1 (human)	TGF-beta/Smad p38 MAPK	Inflammation/Immunology
Klotho-derived peptide 1 (KP1 human) blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced activation of Smad2/3 and mitogen-activated protein kinase (MAPK), and exhibits anti-fibrotic and kidney protective effects in mouse model .

HY-P5270

Hexapeptide-12	Peptides	Metabolic Disease
Hexapeptide-12isa bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

HY-P5279

Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine	Peptides	Metabolic Disease
Palmitoyl dipeptide-7 is a bioactive peptide with anti-aging effects that has been reported for use as a cosmetic ingredient.

Cat. No.	Product Name	Target	Research Area	Image

HY-P990964

Efimosfermin alfa BOS-580; LLF580	FGFR	Metabolic Disease Inflammation/Immunology
Efimosfermin alfa is a genetically engineered FGF21 variant. Efimosfermin alfa exerts its function by activating the FGFR1c/β-Klotho complex. Efimosfermin alfa is applicable to researches on metabolic dysfunction-associated steatohepatitis, obesity and mild hypertriglyceridemia .

HY-P99614

Fazpilodemab BFKB8488A; RG-7992; RO-7040551	FGFR	Metabolic Disease
Fazpilodemab (BFKB8488A) is a humanized bispecific IgG1 antibody that selectively targets and activates fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. Fazpilodemab can be used for the research of type 2 diabetes mellitus (T2DM) or nonalcoholic fatty liver disease (NAFLD) .

HY-P990636

NGM-313 MK-3655	Inhibitory Antibodies	Inflammation/Immunology
NGM-313 is a CHO-expressed human antibody targeting Klotho Beta. NGM-313 contains a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for NGM-313 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P992195

*Anti-Beta Klotho* Antibody**	FGFR	Inflammation/Immunology
Anti-Beta Klotho Antibody is a monoclonal antibody targeting Beta Klotho*. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Beta Klotho* Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).

Species:	Human (4) Rhesus Macaque (1) Mouse (1) Cynomolgus (1)
Tag:	His (5) GST (1)
Source:	HEK293 (4) CHO (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P77972

	Klotho beta Protein, Human (HEK293, His) betaKlotho; beta-Klotho; BKL; KLB; Klotho beta like; Klotho beta; MGC142213	Human	HEK293
	Klotho beta protein plays a critical role in the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), a key enzyme controlling bile acid synthesis. Although its glycosidase activity may be inactive, Klotho beta enhances the binding ability of FGFR1 and FGFR4 to FGF21, promoting their interaction. Klotho beta Protein, Human (HEK293, His) is the recombinant human-derived Klotho beta protein, expressed by HEK293 , with C-His labeled tag.

HY-P78714

	Klotho beta Protein, Mouse (HEK293, His) betaKlotho; beta-Klotho; BKL; KLB; Klotho beta like; Klotho beta-like protein	Mouse	HEK293
	Klotho beta protein represses cholesterol 7-alpha-hydroxylase (CYP7A1), a key enzyme in bile acid synthesis. It enhances binding between fibroblast growth factor receptors and fibroblast growth factor 21, and directly interacts with FGF19 and FGF21. This positions Klotho beta as a crucial modulator of metabolic and growth factor signaling pathways. Klotho beta Protein, Mouse (HEK293, His) is the recombinant mouse-derived Klotho beta protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P700011

	Klotho Protein, Human (CHO, His) 1 Publications Verification α-Klotho	Human	CHO
	Klotho Protein exhibits weak glycosidase activity against glucuronidated steroids and is inactive in vivo due to the lack of essential active site Glu residues. It regulates calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Klotho Protein, Human (CHO, His) is the recombinant human-derived Klotho protein, expressed by CHO , with C-10*His labeled tag.

HY-P704735

	Klotho beta Protein, Human (968a.a, HEK293, His) betaKlotho; beta-Klotho; BKL; KLB; Klotho beta like; Klotho beta; MGC142213	Human	HEK293
	Klotho beta protein plays a critical role in the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), a key enzyme controlling bile acid synthesis. Although its glycosidase activity may be inactive, Klotho beta enhances the binding ability of FGFR1 and FGFR4 to FGF21, promoting their interaction. Klotho beta Protein, Human (968a.a, HEK293, His) is the recombinant human-derived Klotho beta protein, expressed by HEK293, with C-His labeled tag.

HY-P705496

	Klotho beta Protein, Cynomolgus/Rhesus Macaque (HEK293, His) betaKlotho; beta-Klotho; BKL; KLB; Klotho beta like; Klotho beta-like protein	Rhesus Macaque;Cynomolgus	HEK293

HY-P71650

	Cytosolic beta-Glucosidase/GBA3 Protein, Human (GST) CBG; CBGL1; Cytosolic beta glucosidase ; Cytosolic beta glucosidase like protein 1; Cytosolic beta-glucosidase; Glucosidase beta acid 3; Klotho related protein ; KLRP	Human	E. coli
	Cytosolic β-glucosidase/GBA3 is a multifunctional neutral cytosolic β-glucosidase that displays broad substrate specificity, suggesting a possible involvement in glycosylceramide catabolism. Although it exhibits significant glucosylceramidase activity in vitro, its in vivo relevance is unclear. Cytosolic beta-Glucosidase/GBA3 Protein, Human (GST) is the recombinant human-derived Cytosolic beta-Glucosidase/GBA3 protein, expressed by E. coli , with N-GST labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2) Mouse (2)
Application:	IHC-P (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83610

	Klotho Antibody (YA3355) Kl; Klotho peptide	WB, IHC-P	Human, Mouse
	Klotho Antibody (YA3355) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Klotho.

HY-P87179

	Klotho Antibody(YA6870) Kl; Klotho peptide	WB, IHC-P	Human, Mouse
	Klotho Antibody(YA6870) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Klotho.

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