18 Results for "

Klotho

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "Klotho" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P700011
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KL; Alpha-Klotho; Klotho; HFTC3; KLA
Species:  
Source:  
CHO
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Cat. No.: HY-P990964
CAS No.: 2765640-39-7
Synonyms: BOS-580; LLF580

Target:  

FGFR

Efimosfermin alfa is a genetically engineered FGF21 variant. Efimosfermin alfa exerts its function by activating the FGFR1c/β-Klotho complex. Efimosfermin alfa is applicable to researches on metabolic dysfunction-associated steatohepatitis, obesity and mild hypertriglyceridemia .
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Cat. No.: HY-P99614
CAS No.: 2517935-02-1
Synonyms: BFKB8488A; RG-7992; RO-7040551

Target:  

FGFR

Research Areas:  

Metabolic Disease

Fazpilodemab (BFKB8488A) is a humanized bispecific IgG1 antibody that selectively targets and activates fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. Fazpilodemab can be used for the research of type 2 diabetes mellitus (T2DM) or nonalcoholic fatty liver disease (NAFLD) .
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Cat. No.: HY-150687
CAS No.: 1010888-06-8
Target:  

ERK

Research Areas:  

Metabolic Disease

ZINC12409120 is a high selective ERK inhibitor. ZINC12409120 acts on disrupting FGF23:α-Klotho interaction to inhibit ERK activity with an IC50 of 5.0 μM .
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Cat. No.: HY-P10414A
Synonyms: KP1 (human) hydrochloride
Target:  

TGF-β Receptor

Research Areas:  

Infection Endocrinology

Klotho-derived peptide 1 hydrochloride (KP1 (human) hydrochloride) is a polypeptide with multiple activities including senescence inhibition and renal protection. Klotho-derived peptide 1 hydrochloride binds to TβR2 and ATAD3A, with a Kd value of 1.41 μM for binding to human TβR2 and a Kd value of 0.319 μM for binding to ATAD3A. By binding to TβR2, Klotho-derived peptide 1 hydrochloride blocks the TGF-β/Smad3 and downstream TGF-β signaling pathways, inhibits the expression of miR-223-3p, induces the expression of lncRNA-TUG1, restores endogenous Klotho at the post-transcriptional level, inhibits cellular senescence markers, fibroblast activation and renal tubular epithelial cell apoptosis, blocks cytochrome c release and caspase activation, maintains the integrity of mitochondrial ultrastructure, and restores mitochondrial protein levels. Klotho-derived peptide 1 hydrochloride enters renal tubular epithelial cells via endocytosis, protects against nephrotoxic and hypoxic injuries, and recapitulates the renal protective and anti-fibrotic effects of full-length Klotho. Klotho-derived peptide 1 hydrochloride can be used in research related to kidney diseases such as chronic kidney disease and SARS-CoV-2-associated acute kidney injury .
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Cat. No.: HY-P990636
Synonyms: MK-3655

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

NGM-313 is a CHO-expressed human antibody targeting Klotho Beta. NGM-313 contains a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for NGM-313 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P10414
Synonyms: KP1 (human)
Target:  

TGF-β Receptor

Research Areas:  

Infection Endocrinology

Klotho-derived peptide 1 (KP1 (human)) is a polypeptide with multiple activities including senescence inhibition and renal protection. Klotho-derived peptide 1 binds to TβR2 and ATAD3A, with a Kd value of 1.41 μM for binding to human TβR2 and a Kd value of 0.319 μM for binding to ATAD3A. By binding to TβR2, Klotho-derived peptide 1 blocks the TGF-β/Smad3 and downstream TGF-β signaling pathways, inhibits the expression of miR-223-3p, induces the expression of lncRNA-TUG1, restores endogenous Klotho at the post-transcriptional level, inhibits cellular senescence markers, fibroblast activation and renal tubular epithelial cell apoptosis, blocks cytochrome c release and caspase activation, maintains the integrity of mitochondrial ultrastructure, and restores mitochondrial protein levels. Klotho-derived peptide 1 enters renal tubular epithelial cells via endocytosis, protects against nephrotoxic and hypoxic injuries, and recapitulates the renal protective and anti-fibrotic effects of full-length Klotho. Klotho-derived peptide 1 can be used in research related to kidney diseases such as chronic kidney disease and SARS-CoV-2-associated acute kidney injury .
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Cat. No.: HY-P5270
CAS No.: 70592-18-6
Target:  

Peptides

Research Areas:  

Metabolic Disease

Hexapeptide-12isa bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .
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Cat. No.: HY-P5279
CAS No.: 2228114-98-3
Target:  

Peptides

Research Areas:  

Metabolic Disease

Palmitoyl dipeptide-7 is a bioactive peptide with anti-aging effects that has been reported for use as a cosmetic ingredient.
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Cat. No.: HY-137321
CAS No.: 15087-06-6
Synonyms: Estriol 3-β-D-Glucuronide sodium salt
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

Estriol 3-glucuronide (Estriol 3-β-D-Glucuronide) sodium salt is a metabolite of Estriol. Estriol 3-glucuronide sodium salt competitively inhibits the hydrolysis of 4-methylumbelliferyl-β-D-glucuronide (4Mu-GlcU). Estriol 3-glucuronide sodium salt is a substrate for hydrolysis by Klotho-human IgG1 Fc protein (KLFc) .
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Cat. No.: HY-P992195

Target:  

FGFR

Research Areas:  

Inflammation/Immunology

Anti-Beta Klotho Antibody is a monoclonal antibody targeting *Beta Klotho*. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Beta Klotho Antibody, please refer to Human IgG1 (L234A/L235A) kappa, Isotype Control (HY-P991207).
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Cat. No.: HY-P77972
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: KLB; B-Klotho; Klotho Beta; BKL; Beta-Klotho; Klotho Beta Like; BetaKlotho; KLB Protein; Klotho Beta-Like Protein
Species:  
Source:  
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Cat. No.: HY-P78714
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KLB; B-Klotho; Klotho Beta; BKL; Beta-Klotho; Klotho Beta Like; BetaKlotho; KLB Protein; Klotho Beta-Like Protein
Species:  
Source:  
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Cat. No.: HY-P704735
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KLB; B-Klotho; Klotho Beta; BKL; Beta-Klotho; Klotho Beta Like; BetaKlotho; KLB Protein; Klotho Beta-Like Protein
Species:  
Source:  
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Cat. No.: HY-P83610
Synonyms: Kl; Klotho peptide

Host:  

Rabbit

Application:  

WB, IHC-P

Reactivity:  

Human, Mouse

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Cat. No.: HY-P87179
Synonyms: Kl; Klotho peptide

Host:  

Rabbit

Application:  

WB, IHC-P

Reactivity:  

Human, Mouse

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Cat. No.: HY-P705496
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: betaKlotho; beta-Klotho; BKL; KLB; Klotho beta like; Klotho beta-like protein
Source:  
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Cat. No.: HY-186173
CAS No.: 2314337-87-4
Target:  

ERK FGFR

Research Areas:  

Metabolic Disease

MD-3-A45 is an inhibitor of fibroblast growth factor 23 (FGF-23). MD-3-A45 blocks the activation of the FGFRs/α-klotho signaling pathway by FGF-23 and inhibits FGF-23-induced ERK activation. MD-3-A45 can be used in the research of chronic kidney disease, hereditary hypophosphatemic rickets and acquired hypophosphatemic rickets .
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