Klotho Antibody(YA6870)
(Synonyms: Kl; Klotho peptide)Klotho Antibody(YA6870) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Klotho.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:5000 | 1:50-1:200 |
Product Details
Klotho Antibody(YA6870) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Klotho.
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Host Rabbit
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Clonality Monoclonal, Recombinant
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 62,116 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 62,116 kDa
SwissProt: Q9UEF7 Human ; O35082 Mouse
Synthetic peptide within Human Klotho aa 404-453 / 1,012.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Klotho may have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1; The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Apical cell membrane; Single-pass type I membrane protein; Secreted; Secreted
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Expression
Tissue_specificity:It is present in the renal cortical tubules (protein level) . Soluble peptides are present in serum and cerebrospinal fluid. It is expressed in the kidney, placenta, small intestine, and prostate. Its expression is downregulated in the kidneys of renal cell carcinoma, hepatocellular carcinoma, and chronic renal failure.
Positive sample: Human kidney tissue lysates, Human serum lysate, human kidney tissue lysate, human kidney tissue, mouse kidney tissue. -
Isoforms & Post-Translational Modification
Q9UEF7 has 2 isomers: Q9UEF7-1: 116181 Da (predicted); Q9UEF7-2: 62135 Da (predicted).
N-glycosylated -
Subunit
Homodimer. Interacts with FGF23 and FGFR1
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SwissProt ID
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Synonyms
Kl; Klotho peptide
Documentation
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