2. MAPK/ERK Pathway Stem Cell/Wnt Protein Tyrosine Kinase/RTK
  3. ERK FGFR
  4. MD-3-A45

MD-3-A45 is an inhibitor of fibroblast growth factor 23 (FGF-23). MD-3-A45 blocks the activation of the FGFRs/α-klotho signaling pathway by FGF-23 and inhibits FGF-23-induced ERK activation. MD-3-A45 can be used in the research of chronic kidney disease, hereditary hypophosphatemic rickets and acquired hypophosphatemic rickets.

For research use only. We do not sell to patients.

MD-3-A45

MD-3-A45 Chemical Structure

CAS No. : 2314337-87-4

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MD-3-A45 Related Antibodies

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ERK ERK1 ERK2 ERK5 ERK8

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Description

MD-3-A45 is an inhibitor of fibroblast growth factor 23 (FGF-23). MD-3-A45 blocks the activation of the FGFRs/α-klotho signaling pathway by FGF-23 and inhibits FGF-23-induced ERK activation. MD-3-A45 can be used in the research of chronic kidney disease, hereditary hypophosphatemic rickets and acquired hypophosphatemic rickets[1].

In Vitro

MD-3-A45 completely inhibits FGF-23-induced ERK activation in HEK-293 cells expressing FGFRs/α-Klotho with an IC50 of 0.14 μM, and has a metabolic stability half-life of 9 minutes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MD-3-A45 Related Antibodies
Molecular Weight

237.30

Formula

C16H15NO
CAS No.
SMILES

O/N=C/C1=C(/C=C/C2=CC=C(C)C=C2)C=CC=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MD-3-A45 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MD-3-A452314337-87-4ERKFGFRExtracellular signal regulated kinasesFibroblast growth factor receptorERK activationchronic kidney diseasehereditary hypophosphatemic ricketsFGF-23HEK-293 cellsfibroblast growth factor 23FGFRs/α-Klotho signalingacquired hypophosphatemic ricketsInhibitorinhibitorinhibit

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