FGF-23
FGF-23 is a bone-derived hormone that governs phosphate homeostasis. Secreted by osteocytes and osteoblasts, it binds FGFR1, FGFR3 and FGFR4 in complex with the co-receptor α-klotho in kidney, promoting phosphate excretion by downregulating sodium-phosphate cotransporters and suppressing 1,25-dihydroxyvitamin D synthesis. Excess FGF-23 causes tumor-induced osteomalacia and X-linked hypophosphatemia, while inactivating mutations lead to familial tumoral calcinosis; in chronic kidney disease, rising FGF-23 tracks with cardiovascular risk. Circulating FGF-23 levels are additionally raised in heart failure, where they serve as a prognostic biomarker. Burosumab, an anti-FGF-23 antibody, treats X-linked hypophosphatemia. Recombinant FGF-23 is used in klotho-dependent signaling assays, phosphate-metabolism research and antibody-based diagnostics.
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FGF-23 Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
