Search Result

Results for "

LYP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Cathepsin (1) Complement System (1) Endogenous Metabolite (5) ERK (2) Isotope-Labeled Compounds (4) Liposome (5) NAMPT (1) Notch (1) PD-1/PD-L1 (1) Phosphatase (8) PKC (1) PROTACs (1) SHP1 (1) SHP2 (1) Small Interfering RNA (siRNA) (2) Tyrosinase (1)
By Research Areas:	Cancer (13) Inflammation/Immunology (5) Metabolic Disease (4) Neurological Disease (2)
Oligonucleotides:	Pegylated Lipids (3) Phospholipids (2) Human Pre-designed siRNA Sets (2) siRNAs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011063

Gly-Phe-β-naphthylamide	Cathepsin	Metabolic Disease
Gly-Phe-β-naphthylamide is a substrate of Cathepsin C (HY-P2922) and belongs to the lysosomal agonist. Gly-Phe-β-naphthylamide can freely pass through the cell membrane and organelle membrane. Gly-Phe-β-naphthylamide will be specifically hydrolyzed by Cathepsin C, ultimately leading to a permeability lysis when it enters the acidic compartment. Gly-Phe-β-naphthylamide can be used to study lysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C .

HY-113123

LysoPC(14:0/0:0) 14:0 Lyso PC; 1-myristoyl-sn-glycero-3-phosphatidylcholine	Endogenous Metabolite	Neurological Disease Metabolic Disease
LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .

HY-113010

1-Arachidoyl-sn-glycero-3-phosphocholine	Endogenous Metabolite	Others
1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).

HY-108944

LYP-IN-1	SHP2 SHP1 Phosphatase	Inflammation/Immunology
LYP-IN-1 is a potent, selective and specific *LYP* inhibitor with a K_i and an IC₅₀ of 110 nM and 0.259 μM, respectively. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 (IC₅₀=5 μM) and SHP2 (IC₅₀=2.5 μM). LYP-IN-1 exhibits highly efficacious cellular activity in T- and mast cells. LYP-IN-1 can be used for the study of autoimmune disorders . LYP-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-156659

NC1	Phosphatase ERK	Inflammation/Immunology
NC1 is a selective non-competitive and allosteric lymphoid-specific tyrosine phosphatase (LYP) inhibitor, with a K_i value 4.3 μM. NC1 allosterically regulates LYP/PTPN22 activity by restricting WPD loop movement. NC1 inhibits LYP activity in lymphoid T cells and enhances T-cell receptor signaling. NC1 can be used for the research of autoimmune diseases .

HY-123931

ZLDI-8 1 Publications Verification	Notch Phosphatase Apoptosis	Cancer
ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC₅₀ of 31.6 μM and a K_i of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC₅₀ of 5.32 μM .

HY-P2526

LyP-1 2 Publications Verification	Complement System	Cancer
LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

HY-18667

LTV-1	Phosphatase	Inflammation/Immunology
LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC₅₀ of 508 nM. LTV-1 has the potential for autoimmunity treatment .

HY-124718

p32 Inhibitor M36 M36	PKC	Cancer
p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1 .

HY-138622

24:0 Lyso PC	Liposome	Others
24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-155848

LYP-IN-4	Phosphatase	Cancer
LYP-IN-4 (compound D14) is a reversible and selective inhibitor of lymphotyrosine phosphatase (LYP) (Ki=1.34 μM, IC50=3.52μM). LYP-IN-4 inhibits LYP to regulate TCR signaling, up-regulates PD-1/PD-L1 expression, and enhance anti-tumor immunity. LYP-IN-4 activates T cells and inhibits M2 macrophage polarization, inhibits tumor growth in MC38 isogenic mouse models.

HY-155847

LYP-IN-3	Phosphatase PD-1/PD-L1	Inflammation/Immunology Cancer
LYP-IN-3 is a selective, orally active and reversible lymphoid-tyrosine phosphatase (LYP) inhibitor (IC₅₀ = 2.55 μM, Ki = 0.93 μM). D34 exhibits high selectivity of PTP1B, PTPN12, PTPN5 and SSH2. LYP-IN-3 regulates the T-cell receptor (TCR) signaling by specifically inhibiting *LYP. LYP-IN-3 does not significantly inhibit MC38 cell viability; its anti-tumor effect stems from immune regulation. LYP-IN-3 can significantly upregulate PD-L1* or PD-1 expression in different immune cells. LYP-IN-3 facilitates T-cell infiltration and enhances T-cell functions. LYP-IN-3 synergizes with PD-L1 blockade can significantly improve colorectal tumor regression. LYP-IN-3 can be used for the study of colorectal cancer .

HY-164238

LysoPC(18:3)	Endogenous Metabolite	Cancer
LysoPC(18:3) is a lysophospholipid (LyP). LysoPC(18:3) can be used as a lipid biomarker in the diagnosis of breast cancer .

HY-172271

DSPE-PEG1000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10)	Liposome	Cancer
DSPE-PEG1000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10) is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

HY-113123S1

LysoPC(14:0/0:0)-d7 14:0 Lyso PC-d₇; 1-myristoyl-sn-glycero-3-phosphatidylcholine-d₇	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease Metabolic Disease
LysoPC(14:0/0:0)-d₇ (14:0 Lyso PC-d₇) is deuterium labeled LysoPC(14:0/0:0). LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .

HY-138622S1

24:0 Lyso PC-d4	Isotope-Labeled Compounds	Others
24:0 Lyso PC-d₄4 is the deuterium labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-162537

LYP-8	PROTACs NAMPT	Cancer
LYP-8 is a potent and effective NAMPT degrader with maximum degradation of 97% at 0.5 μM in SKOV-3 cells. LYP-8 shows anti-cancer activity in vivo and in vitro(Sturcture Note:(Blue: Cereblon ligand (HY-112078), Black: linker (HY-128801)；Pink: Nampt inhibitor Nampt-IN-11 (HY-158689)) .

HY-172271C

DSPE-PEG3400-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10)	Liposome	Cancer
DSPE-PEG3400-LyP-1 is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 targets tumor-associated lymphatic vessels and macrophages .

HY-172271A

DSPE-PEG2000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10)	Liposome	Cancer
DSPE-PEG2000-LyP-1 is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

HY-172271B

DSPE-PEG3000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10)	Liposome	Cancer
DSPE-PEG3000-LyP-1 is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

HY-RS11424

PTPN22 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PTPN22 Human Pre-designed siRNA Set A contains three designed siRNAs for PTPN22 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTPN22 Human Pre-designed siRNA Set A PTPN22 Human Pre-designed siRNA Set A

HY-138622S

24:0 Lyso PC-13C6	Isotope-Labeled Compounds	Others
24:0 Lyso PC- ¹³C₆ is the ¹³C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-RS12821

SH2D1A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SH2D1A Human Pre-designed siRNA Set A contains three designed siRNAs for SH2D1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SH2D1A Human Pre-designed siRNA Set A SH2D1A Human Pre-designed siRNA Set A

HY-182299

LYP-IN-5	Phosphatase Tyrosinase ERK	Inflammation/Immunology
LYP-IN-5 is a lymphoid tyrosine phosphatase (LYP) inhibitor with an IC₅₀ value of 20.6 μM. LYP-IN-5 enhances the phosphorylation of ZAP70 and ERK1/2 following TCR stimulation, and promotes T cell activation. LYP-IN-5 can be used in the research of autoimmune diseases .

HY-113010S1

1-Arachidoyl-sn-glycero-3-phosphocholine-d4	Isotope-Labeled Compounds Endogenous Metabolite	Others
1-Arachidoyl-sn-glycero-3-phosphocholine-d₄ is the deuterium labeled 1-Arachidoyl-sn-glycero-3-phosphocholine. 1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).

HY-124420

MLS-0322825	Phosphatase	Metabolic Disease
MLS-0322825 is a selective low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with an IC₅₀ of 3.3 μM for LMPTP-A. MLS-0322825 shows exquisite selectivity over other phosphatases (class I tyrosine-specific lymphoid phosphatase (LYP) and class I dual-specific vaccinia H1-related phosphatase (VHR)). MLS-0322825 can be used for the research of type 2 diabetes ^[1].

24:0 Lyso PC	Biochemical Assay Reagents
24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

DSPE-PEG1000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10)	Biochemical Assay Reagents
DSPE-PEG1000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10) is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

DSPE-PEG3400-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10)	Biochemical Assay Reagents
DSPE-PEG3400-LyP-1 is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 targets tumor-associated lymphatic vessels and macrophages .

DSPE-PEG2000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10)	Biochemical Assay Reagents
DSPE-PEG2000-LyP-1 is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

DSPE-PEG3000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10)	Biochemical Assay Reagents
DSPE-PEG3000-LyP-1 is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

Cat. No.	Product Name	Target	Research Area

HY-P2526

LyP-1 2 Publications Verification	Complement System	Cancer
LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

HY-P2526A

LyP-1 TFA 2 Publications Verification	Peptides	Cancer
LyP-1 TFA is a cyclic 9 amino acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

HY-P4088

LyP-2	Peptides	Cancer
LyP-2 is a peptide that homes to tumor lymphatics. LyP2 homes to lymphatics of C8161 melanomas and cervical carcinomas and K14-HPV16 skin, but not to MDA-MB435 tumors, showing heterogeneity in the molecular markers of tumor cells and lymphatics .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113123

LysoPC(14:0/0:0) 14:0 Lyso PC; 1-myristoyl-sn-glycero-3-phosphatidylcholine	Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite
LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .

HY-113010

1-Arachidoyl-sn-glycero-3-phosphocholine	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).

Cat. No.	Product Name	Chemical Structure

HY-113123S1

LysoPC(14:0/0:0)-d7
LysoPC(14:0/0:0)-d₇ (14:0 Lyso PC-d₇) is deuterium labeled LysoPC(14:0/0:0). LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .

HY-138622S1

24:0 Lyso PC-d4
24:0 Lyso PC-d₄4 is the deuterium labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-138622S

24:0 Lyso PC-13C6
24:0 Lyso PC- ¹³C₆ is the ¹³C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-113010S1

1-Arachidoyl-sn-glycero-3-phosphocholine-d4
1-Arachidoyl-sn-glycero-3-phosphocholine-d₄ is the deuterium labeled 1-Arachidoyl-sn-glycero-3-phosphocholine. 1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).

Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Rat (2) Mouse (2)
Application:	IHC-P (2) WB (2)
Isotype:	IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P88710

	PTPN22 Antibody (YA8394) LYP; LYP1; LYP2; PEP; PTPN8	IHC-P	Human
	PTPN22 Antibody (YA8394) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PTPN22.

HY-P88710A

	PTPN22 Antibody (YA8394)(PBS only) LYP; LYP1; LYP2; PEP; PTPN8	IHC-P	Human
	PTPN22 Antibody (YA8394) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PTPN22.

HY-P82205

	SH2D1A Antibody (YA1950) LYP; SAP; XLP; DSHP; EBVS; IMD5; XLPD; MTCP1; XLPD1; SAP/SH2D1A	WB	Human, Mouse, Rat
	SH2D1A Antibody (YA1950) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SH2D1A.

HY-P82205A

	SH2D1A Antibody (YA1950)(PBS only) LYP; SAP; XLP; DSHP; EBVS; IMD5; XLPD; MTCP1; XLPD1; SAP/SH2D1A	WB	Human, Mouse, Rat
	SH2D1A Antibody (YA1950) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SH2D1A.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-113123

LysoPC(14:0/0:0) 14:0 Lyso PC; 1-myristoyl-sn-glycero-3-phosphatidylcholine		Phospholipids
LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .

HY-138622

24:0 Lyso PC		Phospholipids
24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .

HY-172271

DSPE-PEG1000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10)		Pegylated Lipids
DSPE-PEG1000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10) is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

HY-172271A

DSPE-PEG2000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10)		Pegylated Lipids
DSPE-PEG2000-LyP-1 is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

HY-172271B

DSPE-PEG3000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10)		Pegylated Lipids
DSPE-PEG3000-LyP-1 is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .

HY-RS11424

PTPN22 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PTPN22 Human Pre-designed siRNA Set A contains three designed siRNAs for PTPN22 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12821

SH2D1A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SH2D1A Human Pre-designed siRNA Set A contains three designed siRNAs for SH2D1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

LYP

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
Products