20 Results for "

MCR

" in MedChemExpress (MCE) Product Catalog:
Products (20)

20 Results for "MCR" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-B1456A
CAS No.: 29679-58-1
Synonyms: LILLY-53858
Research Areas:  

Inflammation/Immunology

Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .
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2
2 Cited Publications
Cat. No.: HY-B0288B
CAS No.: 71720-56-4
Synonyms: LILLY-53858 Calcium hydrate
Research Areas:  

Inflammation/Immunology

Fenoprofen (LILLY-53858) Calcium hydrate is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen Calcium hydrate is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen Calcium hydrate also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium hydrate has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .
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1
1 Cited Publications
Cat. No.: HY-N2466
CAS No.: 75921-69-6
Synonyms: MT-I; [Nle4,D-Phe7]-α-MSH
Melanotan I (MT-I; [Nle4,D-Phe7]-α-MSH) is an α-MSH (HY-P0252) analog, synthetic melanotropic peptide, and melanocortin receptor (MCR) agonist. Melanotan I induces skin tanning by mimicking the action of α-MSH on the melanocortin 1 receptor (MC1R) in melanocytes. As an appetite suppressant, Melanotan I impairs the ability of insulin to inhibit endogenous glucose production, suppresses leptin secretion from adipose tissue, and thereby reduces voluntary feed intake in ewes. Melanotan I can be used in research related to UV-induced skin damage, polymorphic light eruption, ruminant feeding, and sexual dysfunction .
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1 Cited Publications
Cat. No.: HY-N10549
CAS No.: 83088-28-2
Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the SLC7A11-GPX4 axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury .
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1
1 Cited Publications
Cat. No.: HY-N2466A
CAS No.: 1566590-77-9
Synonyms: MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate
Melanotan I (MT-I; [Nle4,D-Phe7]-α-MSH) acetate is an α-MSH (HY-P0252) analog, synthetic melanotropic peptide, and melanocortin receptor (MCR) agonist. Melanotan I acetate induces skin tanning by mimicking the action of α-MSH on the melanocortin 1 receptor (MC1R) in melanocytes. As an appetite suppressant, Melanotan I acetate impairs the ability of insulin to inhibit endogenous glucose production, suppresses leptin secretion from adipose tissue, and thereby reduces voluntary feed intake in ewes. Melanotan I acetate can be used in research related to UV-induced skin damage, polymorphic light eruption, ruminant feeding, and sexual dysfunction .
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Cat. No.: HY-105305
CAS No.: 926277-68-1
Synonyms: ABT-719; AP-214
Target:  

Melanocortin Receptor

Research Areas:  

Inflammation/Immunology

Modimelanotide (ABT-719) is an α-melanocyte-stimulating hormone analog. Modimelanotide has high specific binding ability to melanocortin receptors (MCR1, 3, 4, 5). Modimelanotide possesses anti-inflammatory and organ-protective effects. Modimelanotide can be used in the research of diseases such as acute kidney injury .
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Cat. No.: HY-B0288A
CAS No.: 34597-40-5
Synonyms: LILLY-53858 Calcium
Research Areas:  

Inflammation/Immunology

Fenoprofen (LILLY-53858) Calcium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen Calcium is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen Calcium also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .
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Cat. No.: HY-P11362
CAS No.: 100930-04-9
Target:  

Melanocortin Receptor

Research Areas:  

Endocrinology

δ-MSH is a melanocortin peptide. δ-MSH is a weak melanocortin receptor (MCRs) ligand .
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Cat. No.: HY-157892
CAS No.: 123580-46-1
Target:  

Parasite

Research Areas:  

Infection

Antimalarial agent 38 is an orally active antimalarial agent, which inhibits Plasmodium falciparum D6 strain, Chloroquine (HY-17589A)-sensitive Thai strain and Chloroquine-resistant FcB1 strain and K1 strain, with IC50s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC50 >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model .
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Cat. No.: HY-RS09549
Research Areas:  

Others

Nr3c2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nr3c2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS08248
Research Areas:  

Others

MCRS1 Human Pre-designed siRNA Set A contains three designed siRNAs for MCRS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS09547
Research Areas:  

Others

NR3C2 Human Pre-designed siRNA Set A contains three designed siRNAs for NR3C2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P6176
CAS No.: 3032608-72-0
Target:  

Melanocortin Receptor

Research Areas:  

Metabolic Disease Endocrinology

JLB2-110c activates MCRs receptor (mMC4R EC50 = 0.34 nM) and has a strong in vivo appetite suppressant effect .
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Cat. No.: HY-164869
CAS No.: 2863607-71-8
Research Areas:  

Others

1-Hex-GlcNAlk is a metabolic chemical reporter (MCR) utilized in glycosylation research. 1-Hex-GlcNAlk exhibits robust labeling over background with negligible amounts of nonspecific chemical labeling in cell lysates .
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Cat. No.: HY-B1456AR
CAS No.: 29679-58-1
Synonyms: LILLY-53858 (Standard)
Fenoprofen (Standard) (LILLY-53858 (Standard)) is the analytical standard of Fenoprofen (HY-B1456A). This product is intended for research and analytical applications. Fenoprofenc is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis.
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Cat. No.: HY-B0288BR
CAS No.: 71720-56-4
Synonyms: LILLY-53858 Calcium hydrate (Standard)
Fenoprofen (LILLY-53858 (Standard)) (Standard) Calcium hydrate is the analytical standard of Fenoprofen Calcium hydrate (HY-B0288B). This product is intended for research and analytical applications. Fenoprofen is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis.
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Cat. No.: HY-B1456AS
Synonyms: LILLY-53858-13C6 sodium hydrate
Fenoprofen- 13C6 (LILLY-53858- 13C6) sodium hydrate is the 13C labeled Fenoprofen (HY-B1456A).Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .
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Cat. No.: HY-P701313
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Phosphatidylethanolamine transferase MCR-1; EC:2.7.8.43; Polymyxin resistance protein MCR-1; MCR1; MCR-1; APZ14_31440
Species:  
Source:  
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Cat. No.: HY-P71578
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Phosphatidylethanolamine transferase MCR-1; EC:2.7.8.43; Polymyxin resistance protein MCR-1; MCR1; MCR-1; APZ14_31440
Species:  
Source:  
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Cat. No.: HY-105305A
Synonyms: ABT-719 acetate; AP-214 acetate
Target:  

Melanocortin Receptor

Research Areas:  

Endocrinology

Modimelanotide (ABT-719) acetate is an α-melanocyte-stimulating hormone analog. Modimelanotide acetate has high specific binding ability to melanocortin receptors (MCR1, 3, 4, 5). Modimelanotide acetate possesses anti-inflammatory and organ-protective effects. Modimelanotide acetate can be used in the research of diseases such as acute kidney injury .
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