32 Results for "

MICAL2

" in MedChemExpress (MCE) Product Catalog:
Products (32)

32 Results for "MICAL2" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-103316A
CAS No.: 874374-25-1
Purity:  99.92%
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease Cancer

Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca 2+ signaling, with an IC50 of 65 nM . Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice .
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1
1 Cited Publications
Cat. No.: HY-P0107A
CAS No.: 1217463-61-0
Target:  

Bombesin Receptor

Research Areas:  

Inflammation/Immunology

RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice .
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1
1 Cited Publications
Cat. No.: HY-12736A
CAS No.: 2341796-81-2
Purity:  99.37%
Target:  

Syk ERK

Research Areas:  

Inflammation/Immunology Cancer

GSK143 dihydrochloride is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. GSK143 dihydrochloride inhibits phosphorylated Erk (pErk: pIC50=7.1) . GSK143 dihydrochloride reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice .
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1
1 Cited Publications
Cat. No.: HY-P0107
CAS No.: 138147-78-1
Target:  

Bombesin Receptor

Research Areas:  

Inflammation/Immunology

RC-3095 is a bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 exerts protective effects by reducing gastric oxidative injury in the arthritic mice .
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1
1 Cited Publications
Cat. No.: HY-109506S9
CAS No.: 65277-91-0
Purity:  ≥95.0%
Synonyms: 129Y83-13C2
DPPC-13C2 is a deuterated labeled DPPC . DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .
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Cat. No.: HY-N1393
CAS No.: 579-75-9
Synonyms: NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether
2-Methoxybenzoic acid (NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether) is a natural compound with potential salicylate-like effect. 2-Methoxybenzoic acid inhibits carbonic anhydrase activity, elevates intraplatelet cyclic guanosine monophosphate level, and suppresses cytosolic phospholipase A2 phosphorylation. 2-Methoxybenzoic acid suppresses platelet reactivity, including decreased spreading, retraction, and aggregation in platelets. 2-Methoxybenzoic acid ameliorates arterial thrombosis in a dose-dependent manner without affecting normal hemostasis in mice. 2-Methoxybenzoic acid can be used for the research of arterial thrombosis .
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Cat. No.: HY-W010516
CAS No.: 97-61-0
Synonyms: 2-Methylpentanoic acid
2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chain amino acids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].
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Cat. No.: HY-109506S
CAS No.: 25582-63-2
Purity:  ≥99.0%
Synonyms: 129Y83-d62
DPPC-d62 is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers . DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice .
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Cat. No.: HY-75625
CAS No.: 2237-36-7
Synonyms: 4-Methoxysalicylic Acid
2-Hydroxy-4-methoxybenzoic acid is an orally active inhibitor of MCT-1 and MCT-4, as well as a plant biomarker. 2-Hydroxy-4-methoxybenzoic acid can be isolated from roots. 2-Hydroxy-4-methoxybenzoic acid induces Apoptosis and loss of mitochondrial membrane potential. 2-Hydroxy-4-methoxybenzoic acid exhibits anticancer activity against breast cancer. 2-Hydroxy-4-methoxybenzoic acid normalizes lactic acid levels. 2-Hydroxy-4-methoxybenzoic acid neutralizes viper venom and attenuates its lethal, hemorrhagic, coagulant and anticoagulant activities in male albino mice. 2-Hydroxy-4-methoxybenzoic acid possesses antihyperlipidemic, antidiabetic and hepatoprotective activities [2].
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Cat. No.: HY-N0092R
CAS No.: 58-63-9
Inosine (Standard) is the analytical standard of Inosine. This product is intended for research and analytical applications. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors [2] . In Vitro:Inosine dose-dependently stimulates cAMP production mediated through the A2AR [2].
Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation [2].
Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes .
In Vivo:Inosine (10-100 mg/kg; i.p.) exhibits antinociceptive effect in mice .
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Cat. No.: HY-RS08426
Research Areas:  

Others

MICAL2 Human Pre-designed siRNA Set A contains three designed siRNAs for MICAL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS20179
Research Areas:  

Others

Mical2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mical2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS26683
Research Areas:  

Others

Mical2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mical2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-131102
CAS No.: 13297-17-1
Purity:  99.67%
Research Areas:  

Infection

Mequindox is an antimicrobial agent . Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice .
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Cat. No.: HY-W654264
2-Methylbutyrylcarnitine (chloride) is a gut microbial metabolite which binds to integrin α2β1 in platelets, potentiating cytosolic phospholipase A2 (cPLA2) activation and platelet hyperresponsiveness. 2-Methylbutyrylcarnitine (chloride) enhances platelet hyperreactivity and thrombus formation in mice. 2-Methylbutyrylcarnitine (chloride) is a branched-chain acylcarnitine .
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Cat. No.: HY-145119S
CAS No.: 2647442-33-7
Purity:  99.02%
Synonyms: VV116 free base; GS-621763-d1
GS-621763-d1 is the deuterium labeled GS-621763 (HY-145119) . GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice .
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Cat. No.: HY-12736
CAS No.: 1240390-27-5
Target:  

Syk ERK

Research Areas:  

Inflammation/Immunology Cancer

GSK143 is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. GSK143 inhibits phosphorylated Erk (pErk: pIC50=7.1) . GSK143 reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice .
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Cat. No.: HY-113902
CAS No.: 109628-38-8
Target:  

CRM1

Research Areas:  

Cancer

(2-(β-Piperidinoethyl)-9-hydroxyellipticinium chloride (compound 1AA) is a SETBP1 inhibitor that disrupts the interaction between SETBP1 and XPO1. (2-(β-Piperidinoethyl)-9-hydroxyellipticinium chloride inhibits colony formation, induces differentiation/cytotoxicity, and downregulates the transcription of Setbpl target genes. (2-(β-Piperidinoethyl)-9-hydroxyellipticinium chloride improves survival and reduces the spleen size of leukemic mice. (2-(β-Piperidinoethyl)-9-hydroxyellipticinium chloride can be used for myeloid neoplasms and solid tumors research .
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Cat. No.: HY-101139
CAS No.: 96865-92-8
Synonyms: XAC
Target:  

Adenosine Receptor

Research Areas:  

Neurological Disease

Xanthine amine congener is a non-selective adenosine receptor antagonist . Xanthine amine congener induces convulsions in mice .
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Cat. No.: HY-109506S3
CAS No.: 77165-56-1
Synonyms: 129Y83-d9-1
DPPC-d9-1 is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers . DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice .
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