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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
MRGX2
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "MRGX2" in MCE Product Catalog:
9
Target:
Domaines de recherche:
2
2 Cited Publications
Cat. No.: HY-P3419
CAS No.: 929905-12-4
Domaines de recherche:
1
1 Cited Publications
Cat. No.: HY-172458
CAS No.: 473687-20-6
Domaines de recherche:
Z-3578 is an orally active small-molecule antagonist of MrgX2 with potent antipseudoallergic activity, exhibiting a KD value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppresses the release of β-hexosaminidase, significantly reduces the release of histamine and TNF-α, and decreases intracellular calcium flux. In a mouse pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation, and reduces serum histamine levels. Z-3578 can be used for the study of pseudoallergic reactions .
Cat. No.: HY-176446
CAS No.: 2641397-91-1
Domaines de recherche:
Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of MrgX2 receptor with an IC50 value of 0.042-2.5 nM. Mrgx2 antagonist-3 blocks downstream G protein signaling and β-Arrestin recruitment, thereby inhibiting MrgX2 receptor-mediated calcium influx and cellular degranulation. Mrgx2 antagonist-3 is promising for research of inflammation-related diseases and pruritus, such as chronic urticaria, allergic asthma .
Cat. No.: HY-148492
CAS No.: 2767111-67-9
Domaines de recherche:
Mrgx2 antagonist-2 (Example 132) is a Mrgx2 antagonist with a pIC50 of 8.6. Mrgx2 antagonist-2 can be used in the research of MrgX2 -mediated diseases or disorders .
Cat. No.: HY-147106
CAS No.: 2767110-35-8
Domaines de recherche:
Mrgx2 antagonist-1 (example 1) is a potent Mrgx2 (Mas-related Gene X2) antagonist. Mrgx2 antagonist-1 can be used for the research of MrgX2-mediated diseases and disorders.
Cat. No.: HY-174452
CAS No.: 724709-67-5
Domaines de recherche:
BER-5 is a potent MrgX2 antagonist. BER-5 possess broad-spectrum antagonistic activity against a diverse range of MrgX2 agonists. BER-5 can inhibit Substance P (SP) (HY-P0201)-induced degranulation of LAD2 cells. BER-5 attenuates SP-induced allergic reactions in mice. BER-5 can be used for the study of allergic reactions.
Cat. No.: HY-186243
CAS No.: 2527815-63-8
Domaines de recherche:
MRGX2-IN-1 is a MRGX2 inhibitor with a pKd of 7.45 and a pEC50 of 7.867 against hMRGX2. MRGX2-IN-1 can be used for the research of immune diseases .
Cat. No.: HY-106178D
CAS No.: 852629-88-0
Synonyms: 3D53 monoacetate
Target:
Domaines de recherche:
PMX 53 monoacetate (3D53 monoacetate) is a potent orally active CD88 (C5aR) antagonist that inhibits C5a-induced neutrophil myeloperoxide release and chemotactic activity. PMX 53 monoacetate has an IC50 value of 20 nM against C5a-induced neutrophil myeloperoxide release. >The value is 22 nM, and the IC50 value of the chemotactic activity is 75 nM. PMX 53 monoacetate is also an agonist of MrgX2 .
Cat. No.: HY-P3419A
Domaines de recherche:
Cat. No.: HY-RS08651
Target:
Domaines de recherche:
MRGPRX2 Human Pre-designed siRNA Set A contains three designed siRNAs for MRGPRX2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P87425A
Synonyms: MRGX2, MRGPRX2, Mas-related G-protein coupled receptor member X2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
