MRGPRX2 Antibody (YA7113)(PBS only)
(Synonyms: MRGX2, MRGPRX2, Mas-related G-protein coupled receptor member X2)MRGPRX2 Antibody (YA7113) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MRGPRX2.
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Host:
Mouse
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Isotype:
IgG1
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:400 | 1:10000 |
Product Details
MRGPRX2 Antibody (YA7113) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MRGPRX2.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 37kDa;
Purified recombinant fragment of human MRGPRX2 expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MRGPRX2 is a Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A[1].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402). Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007) -
Isoforms & Post-Translational Modification
Q96LB1: 330 amino acids, molecular weight 37099 Da.
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SwissProt ID
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Synonyms
MRGX2, MRGPRX2, Mas-related G-protein coupled receptor member X2
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