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Results for "

NEMO

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (1) Deubiquitinase (1) IFNAR (1) IKK (3) Interleukin Related (1) NF-κB (8) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (6) Neurological Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-176426

Subquinocin	Deubiquitinase NF-κB IFNAR	Cancer
Subquinocin is a tumor suppressor CYLD inhibitor that inhibits USP family deubiquitinases (DUBs) activity of CYLD with an IC₅₀ of 30 μM. Subquinocin enhances the activation of NF-κB and IFN pathways by inhibiting CYLD. Subquinocin promotes RIG-I-mediated activation of IRF3/IRF7 in the interferon pathway. Subquinocin can be used for the research of cancer and neurodegenerative diseases .

HY-123936

SR12343	NF-κB IKK COX Interleukin Related	Neurological Disease Inflammation/Immunology
SR12343 is a IKK/NF-κB inhibitor and a mimetic of the NF-κB essential modulator (NEMO)-binding domain (NBD). SR12343 inhibits TNF-α- and LPS-induced NF-κB activation by blocking the interaction between IKKβ and NEMO. SR12343 suppresses LPS-induced acute pulmonary inflammation in mice. SR12343 extends the healthspan of naturally aged and accelerated aging mice. SR12343 can be used for research on inflammatory and degenerative diseases .

HY-P10839

NBD peptide	NF-κB	Inflammation/Immunology
NBD peptide inhibits NF-κB signaling pathway through inhibition of the NEMO-IKK complex combination. NBD peptide exhibits anti-inflammatory efficacy through block of pro-inflammatory cytokines production. NBD peptide exhibits immunosuppressive activity through regulation of immune cells. NBD peptide enhances its transmembrane ability by combining with cell-penetrating peptide HIV-TAT .

HY-P1847A

IKKγ NBD Inhibitory Peptide TFA	NF-κB	Inflammation/Immunology
IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide TFA could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-P10966A

Tat-IKIP (46-60) TFA	IKK NF-κB	Inflammation/Immunology
Tat-IKIP (46-60) TFA is the trifluoroacetic acid of Tat-IKIP (46-60) (HY-P10966). Tat-IKIP (46-60) is a IκB kinase (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis .

HY-P1847

IKKγ NBD Inhibitory Peptide	NF-κB	Cancer
IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-P10469

NBD-2	NF-κB	Inflammation/Immunology Cancer
NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc .

HY-RS06664

IKBKG Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IKBKG Human Pre-designed siRNA Set A contains three designed siRNAs for IKBKG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IKBKG Human Pre-designed siRNA Set A IKBKG Human Pre-designed siRNA Set A

HY-P10966

Tat-IKIP (46-60)	IKK NF-κB	Inflammation/Immunology
Tat-IKIP (46-60) is a IκB kinase (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis .

Cat. No.	Product Name	Target	Research Area

HY-P10839

NBD peptide	NF-κB	Inflammation/Immunology
NBD peptide inhibits NF-κB signaling pathway through inhibition of the NEMO-IKK complex combination. NBD peptide exhibits anti-inflammatory efficacy through block of pro-inflammatory cytokines production. NBD peptide exhibits immunosuppressive activity through regulation of immune cells. NBD peptide enhances its transmembrane ability by combining with cell-penetrating peptide HIV-TAT .

HY-P1847A

IKKγ NBD Inhibitory Peptide TFA	NF-κB	Inflammation/Immunology
IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide TFA could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-P10966A

Tat-IKIP (46-60) TFA	IKK NF-κB	Inflammation/Immunology
Tat-IKIP (46-60) TFA is the trifluoroacetic acid of Tat-IKIP (46-60) (HY-P10966). Tat-IKIP (46-60) is a IκB kinase (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis .

HY-P1847

IKKγ NBD Inhibitory Peptide	NF-κB	Cancer
IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-P10469

NBD-2	NF-κB	Inflammation/Immunology Cancer
NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc .

HY-P10966

Tat-IKIP (46-60)	IKK NF-κB	Inflammation/Immunology
Tat-IKIP (46-60) is a IκB kinase (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P76517

	*NLK/Nemo* Like Kinase Protein, Human (Active, sf9, His-GST)** Serine/threonine-protein kinase NLK; NEMO-like kinase; NLK	Human	Sf9 insect cells
	NLK/Nemo-like kinase protein is a key serine/threonine protein kinase that directs cell fate through multiple regulatory effects. As a non-canonical Wnt pathway effector, NLK affects transcription factors downstream of WNT5A, MAP3K7/TAK1, and HIPK2. NLK/Nemo Like Kinase Protein, Human (sf9, His-GST) is the recombinant human-derived NLK/Nemo Like Kinase protein, expressed by Sf9 insect cells , with N-GST, N-His labeled tag.

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Host:	Rabbit (4)
Reactivity:	Human (4) Rat (2) Mouse (3)
Application:	IHC-P (3) ICC/IF (3) IP (2) WB (4) FC (2) ELISA (1)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (4)
Clonality:	polyclonal (1) Monoclonal (3) Recombinant (2)
Modification:	Unmodified (4)

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HY-P83194

	NLK Antibody (YA2939) LAK1; NEMO like kinase; Nlk	WB, FC	Human
	NLK Antibody (YA2939) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NLK.

HY-P810366

	NLK Antibody DKFZp761G1211, FLJ21033, LAK1, NEMO like kinase, NEMO-like kinase, Nlk, NLK_HUMAN, Protein LAK1, Serine/threonine protein kinase NLK, Serine/threonine-protein kinase NLK	WB, ICC/IF, IHC-P	Human, Mouse
	NLK Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to NLK.

HY-P86607

	Optineurin Antibody (YA6299) Optineurin; E3-14.7K-interacting protein; FIP-2; Huntingtin yeast partner L; Huntingtin-interacting protein 7; HIP-7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Transcription factor IIIA-interacting protein; TFIIIA-IntP;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Optineurin Antibody (YA6299) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Optineurin.

HY-P80415

	IKK gamma Antibody (YA346)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	IKK gamma Antibody (YA346) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK gamma.

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Cat. No.	Product Name		Classification

HY-RS06664

IKBKG Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IKBKG Human Pre-designed siRNA Set A contains three designed siRNAs for IKBKG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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