2055101-86-3
Chemical Structure
SR12343
- CAS No.: 2055101-86-3
- Formula:C15H15BrClN3O
- Molecular Weight:368.66
IUPAC Name: N-(3-bromophenethyl)-2-((5-chloropyridin-2-yl)amino)acetamide
InChIKey: PEOFCAIUELALCR-UHFFFAOYSA-N
SMILES: O=C(NCCC1=CC=CC(Br)=C1)CNC2=NC=C(Cl)C=C2
Biological Activity: SR12343 is a IKK/NF-κB inhibitor and a mimetic of the NF-κB essential modulator (NEMO)-binding domain (NBD). SR12343 inhibits TNF-α- and LPS-induced NF-κB activation by blocking the interaction between IKKβ and NEMO. SR12343 suppresses LPS-induced acute pulmonary inflammation in mice. SR12343 extends the healthspan of naturally aged and accelerated aging mice. SR12343 can be used for research on inflammatory and degenerative diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SR12343 | 99.66% | SR12343 is a IKK/NF-κB inhibitor and a mimetic of the NF-κB essential modulator (NEMO)-binding domain (NBD). SR12343 inhibits TNF-α- and LPS-induced NF-κB activation by blocking the interaction between IKKβ and NEMO. SR12343 suppresses LPS-induced acute pulmonary inflammation in mice. SR12343 extends the healthspan of naturally aged and accelerated aging mice. SR12343 can be used for research on inflammatory and degenerative diseases. | ||||||||||||||||||||
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- [1]. Benhamú B, et al. New Trends in Aging Drug Discovery. Biomedicines. 2022;10(8):2006. Published 2022 Aug 18. [Content Brief]
- [2]. Zhao J, et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018;16(6):e2004663. Published 2018 Jun 11. [Content Brief]
Keywords
