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Results for "

NSP-10

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

3

Recombinant Proteins

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-171006
    IRF1-IN-1
    1 Publications Verification

    		 Caspase PARP Pyroptosis Interleukin Related IFNAR Infection Inflammation/Immunology
    IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor. IRF1-IN-1 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-1 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1). IRF1-IN-1 has a protective effect on ionizing radiation-induced inflammatory skin injury .
    IRF1-IN-1
  • HY-171007
    IRF1-IN-2
    1 Publications Verification

    		 Caspase PARP Pyroptosis Interleukin Related Glutathione Peroxidase IFNAR Infection Inflammation/Immunology
    IRF1-IN-2 (Compound I-19) is an IRF1 inhibitor. IRF1-IN-2 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-2 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1; inhibits the Pho of TKB1, upregulates GPX4 and downregulates FACL4). IRF1-IN-2 has a protective effect on ionizing radiation-induced inflammatory skin injury .
    IRF1-IN-2
  • HY-124654
    SS148

    		SARS-CoV Metabolic Disease
    SS148 is a dual inhibitor of nsp14/nsp16 MTase. SS148 significant inhibits nsp10–nsp16 with an IC50 of 1.2 μM .
    SS148
  • HY-155280
    SARS-CoV-2-IN-60

    		SARS-CoV Infection
    SARS-CoV-2-IN-60 (compound 5a) is an S-adenosylmethionine (SAM)-competitive and irreversible SARS-CoV-2 nsp16-nsp10 methyltransferase activity inhibitor with an IC50 of 9 μM and a Ki of 26 μM. SARS-CoV-2-IN-60 can specifically occupy a newly identified pocket adjacent to the SAM-binding site on nsp16. SARS-CoV-2-IN-60 has the potential for pan-coronavirus therapeutics .
    SARS-CoV-2-IN-60

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