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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
NSP-10
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "NSP-10" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-171006
CAS No.: 701225-07-2
Target:
Research Areas:
IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor. IRF1-IN-1 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-1 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1). IRF1-IN-1 has a protective effect on ionizing radiation-induced inflammatory skin injury .
1
1 Cited Publications
Cat. No.: HY-171007
CAS No.: 708245-32-3
Research Areas:
IRF1-IN-2 (Compound I-19) is an IRF1 inhibitor. IRF1-IN-2 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-2 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1; inhibits the Pho of TKB1, upregulates GPX4 and downregulates FACL4). IRF1-IN-2 has a protective effect on ionizing radiation-induced inflammatory skin injury .
Cat. No.: HY-124654
CAS No.: 1985669-27-9
Target:
Research Areas:
SS148 is a dual inhibitor of nsp14/nsp16 MTase. SS148 significant inhibits nsp10–nsp16 with an IC50 of 1.2 μM .
Cat. No.: HY-155280
CAS No.: 331647-89-3
SARS-CoV-2-IN-60 (compound 5a) is an S-adenosylmethionine (SAM)-competitive and irreversible SARS-CoV-2 nsp16-nsp10 methyltransferase activity inhibitor with an IC50 of 9 μM and a Ki of 26 μM. SARS-CoV-2-IN-60 can specifically occupy a newly identified pocket adjacent to the SAM-binding site on nsp16. SARS-CoV-2-IN-60 has the potential for pan-coronavirus therapeutics .
Cat. No.: HY-P703532
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Replicase polyprotein 1ab; pp1ab; ORF1ab polyprotein; Host translation inhibitor NSP1; Leader protein; Non-structural protein 1 (NSP1); Non-structural protein 2 (NSP2); p65 homolog; Papain-like protease NSP3 (EC:3.2.2.-, EC:3.4.19.12, EC:3.4.22.-); Non-
Cat. No.: HY-P703533
Synonyms: Replicase polyprotein 1ab; pp1ab; ORF1ab polyprotein; Host translation inhibitor NSP1; Leader protein; Non-structural protein 1 (NSP1); Non-structural protein 2 (NSP2); p65 homolog; Papain-like protease NSP3 (EC:3.2.2.-, EC:3.4.19.12, EC:3.4.22.-); Non-
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
