1985669-27-9
1985669-27-9
Chemical Structure
SS148
- CAS No.: 1985669-27-9
- Formula:C16H20N6O5S
- Molecular Weight:408.43
IUPAC Name: S-(((2S,3S,4R,5R)-5-(4-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)-L-homocysteine
InChIKey: XLTWYAYAFLGUEQ-OPYVMVOTSA-N
SMILES: N#CC1=CN(C2=NC=NC(N)=C21)[C@@H]3O[C@H](CSCC[C@@H](C(O)=O)N)[C@@H](O)[C@H]3O
Biological Activity: SS148 is a dual inhibitor of nsp14/nsp16 MTase. SS148 significant inhibits nsp10–nsp16 with an IC50 of 1.2 μM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SS148 | SS148 is a dual inhibitor of nsp14/nsp16 MTase. SS148 significant inhibits nsp10–nsp16 with an IC50 of 1.2 μM. | |||||||||||||||||||||
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References
- [1]. Nigam A, et al. Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors. bioRxiv [Preprint]. 2023 Nov 13:2023.10.03.560722. [Content Brief]
- [2]. Klima M, et al. Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16. Protein Sci. 2022 Sep;31(9):e4395. [Content Brief]
Keywords
