SS148
SS148 is a dual inhibitor of nsp14/nsp16 MTase. SS148 significant inhibits nsp10–nsp16 with an IC50 of 1.2 μM.
For research use only. We do not sell to patients.
- CAS No.: 1985669-27-9
- Formula: C16H20N6O5S
- Molecular Weight:408.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 1985669-27-9
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Molecular Weight 408.43
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Formula C16H20N6O5S
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SMILES
N#CC1=CN(C2=NC=NC(N)=C21)[C@@H]3O[C@H](CSCC[C@@H](C(O)=O)N)[C@@H](O)[C@H]3O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Nigam A, et al. Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors. bioRxiv [Preprint]. 2023 Nov 13:2023.10.03.560722. [Content Brief]
[2]. Klima M, et al. Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16. Protein Sci. 2022 Sep;31(9):e4395. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SS148 Related Classifications
HY-124654 Related Classifications
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