331647-89-3
331647-89-3
Chemical Structure
SARS-CoV-2-IN-60
- CAS No.: 331647-89-3
- Formula:C13H7Cl2F3N2O
- Molecular Weight:335.11
InChIKey: MMOUYBCDJMEUFG-DUXPYHPUSA-N
SMILES: ClC1=CC=C(/C=C/C2=NC(O)=NC(C(F)(F)F)=C2)C(Cl)=C1
Biological Activity: SARS-CoV-2-IN-60 (compound 5a) is an S-adenosylmethionine (SAM)-competitive and irreversible SARS-CoV-2 nsp16-nsp10 methyltransferase activity inhibitor with an IC50 of 9 μM and a Ki of 26 μM. SARS-CoV-2-IN-60 can specifically occupy a newly identified pocket adjacent to the SAM-binding site on nsp16. SARS-CoV-2-IN-60 has the potential for pan-coronavirus therapeutics[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SARS-CoV-2-IN-60 | 99.22% | SARS-CoV-2-IN-60 (compound 5a) is an S-adenosylmethionine (SAM)-competitive and irreversible SARS-CoV-2 nsp16-nsp10 methyltransferase activity inhibitor with an IC50 of 9 μM and a Ki of 26 μM. SARS-CoV-2-IN-60 can specifically occupy a newly identified pocket adjacent to the SAM-binding site on nsp16. SARS-CoV-2-IN-60 has the potential for pan-coronavirus therapeutics. | ||||||||||||||||||||
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References
Keywords
