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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
P11
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "P11" in MCE Product Catalog:
8
8 Publications Verification
Synonyms: TER199free base; TLK199
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2 Cited Publications
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NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor .
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Piromelatine (Neu-P11) is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities .
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Cat. No.: HY-P10294
CAS No.: 593266-60-5
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P11 is a selective inhibitor of platelet-activating factor acetylhydrolases (PAFAHs) 1b2 and 1b3 that impairs cancer cell survival. P11 exhibits IC50 values of ~40 and 900 nM for PAFAH1b2 and 1b3, respectively .
Cat. No.: HY-176428
CAS No.: 3120743-91-8
Synonyms: P11-2
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PROTAC MNK1 degrader-1 is a selective MNK1 PROTAC degrader with a DC50 of 11.92 nM, and a Dmax > 96% in MV4-11 cells. PROTAC MNK1 degrader-1 significantly reduces p-eIF4E (IC50: 22.07 nM), induces apoptosis, and arrests the cell cycle at the G1 phase. PROTAC MNK1 degrader-1 has potent antitumor activity. PROTAC MNK1 degrader-1 has robust antileukemic efficacy in MV4-11 xenograft mice model with acceptable drug safety .
Cat. No.: HY-16124
CAS No.: 158382-37-7
Synonyms: TLK-286; TER286
Canfosfamide (TLK-286, TER286) is a glutathione analogue prodrug that is activated by glutathione S-transferase P1-1 and induces apoptosis. Canfosfamide also inhibits the catalytic kinase activity of DNA-dependent protein kinase (DNA-PK). Canfosfamide produces an anticancer alkylating agent and a glutathione derivative after activation. Canfosfamide can be used to research malignancies .
Cat. No.: HY-171715
CAS No.: 3056740-00-9
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PL-13 (Compound P11) is the derivative of Trabectedin. PL-13 can disrupt the function of DNA and induces apoptosis in cancer cells. PL-13 be can be used for the research of cancer .
Cat. No.: HY-RS12372
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S100A10 Human Pre-designed siRNA Set A contains three designed siRNAs for S100A10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P11264
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Cat. No.: HY-RS16798
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S100a10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for S100a10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-13634
CAS No.: 286942-97-0
Synonyms: TER199; TLK199 hydrochloride
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Cat. No.: HY-P10052
CAS No.: 612096-46-5
Cat. No.: HY-105285R
CAS No.: 946846-83-9
Synonyms: Neu-P11 (Standard)
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Reference Standards Melatonin Receptor 5-HT Receptor P2X Receptor TRP Channel Sodium Channel
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Piromelatine (Standard) is the analytical standard of Piromelatine. This product is intended for research and analytical applications. Piromelatine (Neu-P11) is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities .
Cat. No.: HY-114688
CAS No.: 62959-30-2
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BITC-SG is the conjugate of phenylisothiocyanate (BITC) and glutathione (GSH). BITC-SG is involved in the irreversible inhibition of GST P1-1 .
Cat. No.: HY-16123
CAS No.: 439943-59-6
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Canfosfamide (hydrochloride) is a prodrug that upon activation by glutathione s-transferase P1-1 (GSTP1-1) yields an anticancer alkylating agent and a glutathione derivative.
Cat. No.: HY-P992283
Cat. No.: HY-169058
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GSTP1-1 inhibitor 2 (Compound 5g) is an hGSTP1-1 (glutathione S-transferase P1-1) inhibitor with an IC50 value of 12.2 μM. GSTP1-1 inhibitor 2 exhibits significant cytotoxicity against DU-145, PC3, and MCF-7 cell lines, with CC50 values of 36.6 μM, 11.9 μM, and 17.4 μM, respectively. It can be used in cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
