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United States

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Referencia número: HY-P11264

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Cyclic peptide P1-1

Cyclic peptide P1-1 is a high-potent GPR55 antagonist. Cyclic peptide P1-1 antagonizes GPR55 and suppresses collagen secretion. Cyclic peptide P1-1 reduces ROS production, attenuates ER stress, and inhibits mitochondria-associated Apoptosis. Cyclic peptide P1-1 inhibits the expression of α-SMA and COL1α. Cyclic peptide P1-1 ameliorates CCl₄ (HY-Y0298)-induce and MCD-diet-induce acute liver inflammation and fibrosis.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₄₀H₇₀N₁₂O₁₃S₂
Peso molecular:991.19

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cyclic peptide P1-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

Chemical Information

Peso molecular 991.19
Fòrmula C₄₀H₇₀N₁₂O₁₃S₂
Sequence

Cys-Lys-Lys-Asn-Ser-Pro-Thr-Ile-Cys (Disulfide bridge: Cys1-Cys9)
Sequence Shortening

CKKNSPTIC (Disulfide bridge: Cys1-Cys9)
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Shi Z, et al. Discovery of Novel Peptide Antagonists Targeting GPR55 for Liver Inflammation and Fibrosis. J Med Chem. 2024 Jul 25;67(14):12085-12098. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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