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S100A10 Antibody (YA675)

(Synonyms: S100A10; 42C; ANX2L; ANX2LG; CAL1L; CLP11; Ca[1]; GP11; P11; p10)
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Based on 1 publication(s) in Google Scholar

S100A10 Antibody (YA675) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to S100A10.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF, IP

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for S100A10 Antibody (YA675)
  • S100A10 Antibody (YA675) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:500-1:1000 1:50-1:200 1:20

Product Details

Description

S100A10 Antibody (YA675) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to S100A10.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 11 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 11 kDa
Species Reactivity Database
Immunogen

Synthetic peptide corresponding to Mouse S100A10.The exact sequence is proprietary to MCE.

Sensitivity

Endogenous

Purification

affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3102246

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for S100A10 Antibody (YA675)
    Western blot analysis of extracts from C6 (lane 2(20μg), C6 (lane 3(40μg), using S100A10 Antibody. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in TBST for 2 hour at room temperature. The primary antibody and Loading control antibody (Beta Actin, HY-P80438, 1/3000) was used in 5% BSA in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (HY-P8004/HY-P8001, 1/10,000) was used for 1 hour at room temperature.

Background

  • Function

    S100A10, also known as p11, functions as a membrane-associated scaffold that forms a heterotetrameric complex with annexin A2 and regulates localization and function of receptors, ion channels, and plasminogen-activation machinery[1]. Mechanistically, annexin A2 stabilizes and anchors S100A10 at the plasma membrane, where S100A10 supports plasminogen binding, plasmin generation, fibrinolysis, and extracellular matrix invasion[2][3]. In macrophage models, S100A10 loss reduced plasmin generation, impaired Matrigel invasion, decreased pro-MMP-9 activation, and limited macrophage recruitment during inflammatory stimulation[4]. In tumor models, S100A10 was essential for tumor-promoting macrophage migration into tumor sites, linking the S100A10-plasmin axis to cancer microenvironment research[5]. In neural models, p11 increased 5-HT1B receptor localization at the cell surface and altered depression-like behavioral states, supporting its use in serotonin receptor trafficking studies[6]. Compared with related S100 isoforms, S100A10 is distinguished by Ca2+-insensitive EF-hand mutations and a constitutively exposed target-binding surface[7]. For experimental applications, S100A10 inhibition or genetic deletion provides a practical strategy to test plasmin-dependent invasion, fibrinolysis, macrophage recruitment, and receptor-trafficking mechanisms[3][4][6].

  • Subunit

    Interacts with TASOR (PubMed:31112734)

  • SwissProt ID

    P08207

  • Gene ID
    6281 [NCBI]
  • Synonyms

    S100A10; 42C; ANX2L; ANX2LG; CAL1L; CLP11; Ca[1]; GP11; P11; p10

  • Research Field

    Signal Transduction

[1]. Liu L, et al. Structure-Based Virtual Screening Accelerates GPCR Drug Discovery. Trends Pharmacol Sci. 2020 Jun;41(6):382-384. [Content Brief]

[2]. Réty S, et al. The crystal structure of a complex of p11 with the annexin II N-terminal peptide. Nat Struct Biol. 1999 Jan;6(1):89-95. [Content Brief]

[3]. Surette AP, et al. Regulation of fibrinolysis by S100A10 in vivo. Blood. 2011 Sep 15;118(11):3172-81. [Content Brief]

[4]. O'Connell PA, et al. S100A10 regulates plasminogen-dependent macrophage invasion. Blood. 2010 Aug 19;116(7):1136-46. [Content Brief]

[5]. Phipps KD, et al. Plasminogen receptor S100A10 is essential for the migration of tumor-promoting macrophages into tumor sites. Cancer Res. 2011 Nov 1;71(21):6676-83. [Content Brief]

[6]. Svenningsson P, et al. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science. 2006 Jan 6;311(5757):77-80. [Content Brief]

[7]. Hermann A, et al. S100 calcium binding proteins and ion channels. Front Pharmacol. 2012 Apr 25;3:67. [Content Brief]

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S100A10 Antibody (YA675) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedchemExpress Validation
     Western blot analysis of extracts from C6 (lane 2(20μg), C6 (lane 3(40μg), using S100A10 Antibody. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in TBST for 2 hour at room temperature. The primary antibody and Loading control antibody (Beta Actin, HY-P80438, 1/3000) was used in 5% BSA in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (HY-P8004/HY-P8001, 1/10,000) was used for 1 hour at room temperature.

  • S100A10 Antibody (YA675) Product Image
    1/16
  • Experimental Validation Results for S100A10 Antibody (YA675)
  • S100A10 Antibody (YA675) Product Image
  • Experimental Validation Results for S100A10 Antibody (YA675)
    1/1
    MedchemExpress Validation
     Western blot analysis of extracts from C6 (lane 2(20μg), C6 (lane 3(40μg), using S100A10 Antibody. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in TBST for 2 hour at room temperature. The primary antibody and Loading control antibody (Beta Actin, HY-P80438, 1/3000) was used in 5% BSA in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (HY-P8004/HY-P8001, 1/10,000) was used for 1 hour at room temperature.
  • Experimental Validation Results for S100A10 Antibody (YA675)
  • S100A10 Antibody (YA675) Product Image
    MedchemExpress Validation

    Western blot analysis of extracts from C6 (lane 2(20μg), C6 (lane 3(40μg), using S100A10 Antibody. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in TBST for 2 hour at room temperature. The primary antibody and Loading control antibody (Beta Actin, HY-P80438, 1/3000) was used in 5% BSA in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (HY-P8004/HY-P8001, 1/10,000) was used for 1 hour at room temperature.

  • S100A10 Antibody (YA675) Product Image WB