S100A10 - S100 calcium binding protein A10 Gene

Also Known as 42C; P11; p10; GP11; ANX2L; CAL1L; CLP11; Ca[1]; ANX2LG

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6281

About S100A10

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,982,915-151,993,859 (from NCBI)

This gene has 4 transcripts (splice variants), 246 orthologues and 21 paralogues. Broad expression in colon (RPKM 299.3), esophagus (RPKM 210.9) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]

S100A10 Products (1)

mRNA	Protein	Name
NM_002966.3	NP_002957.1	protein S100-A10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables lipid binding	IDA IDA: Inferred from direct assay	23861394	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14699089	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	23091277	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	12198146	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in membrane raft assembly	IDA IDA: Inferred from direct assay	23861394	GOA
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	23129259	GOA
involved in positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	23129259	GOA
involved in positive regulation of plasminogen activation	IDA IDA: Inferred from direct assay	9836589	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	23129259	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	23129259	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	12198146	GOA
involved in vesicle budding from membrane	IDA IDA: Inferred from direct assay	23861394	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of AnxA2-p11 complex	IDA IDA: Inferred from direct assay	23091277	GOA
part of RNA polymerase II transcription regulator complex	EXP EXP: Inferred from Experiment	23415230	GOA
colocalizes with membrane raft	IDA IDA: Inferred from direct assay	14699089	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	3126079	GOA
part of plasma membrane protein complex	IPI IPI: Inferred from physical interaction	9886297	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A10 Protein Structure

S_100

0
97 a.a.

Protein Preferred Names	Protein Names
protein S100-A10	S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))

S100A10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	S100A10	P60903	ZGPAT	Homo sapiens	Q8N5A5-2	Validated Y2H	32296183
Intra	S100A10	P60903	HLTF	Homo sapiens	Q14527	Pull Down	23415230
Intra	S100A10	P60903	TRPM4	Homo sapiens	Q8TD43	FPS	31837246
Intra	S100A10	P60903	S100Z	Homo sapiens	Q8WXG8	Validated Y2H	32296183
Intra	S100A10	P60903	S100Z	Homo sapiens	Q8WXG8	Y2H Array	32296183
Intra	S100A10	P60903	S100Z	Homo sapiens	Q8WXG8	Y2H Prey Pooling	32296183
Intra	S100A10	P60903	MLKL	Homo sapiens	Q8NB16-2	Y2H Array	32296183
Intra	S100A10	P60903	MLKL	Homo sapiens	Q8NB16-2	Y2H Prey Pooling	32296183
Intra	S100A10	P60903	MLKL	Homo sapiens	Q8NB16-2	Validated Y2H	32296183
Intra	S100A10	P60903	AHNAK	Homo sapiens	Q09666	X-Ray Diffraction	23415230
Intra	S100A10	P60903	ANXA2	Homo sapiens	P07355	Crosslink	30021884
Intra	S100A10	P60903	ANXA2	Homo sapiens	P07355	Anti Bait CoIP	24457100
Intra	S100A10	P60903	ANXA2	Homo sapiens	P07355	IF	24457100

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74586	S100A10 Protein, Human (His)	P60903 (P2-K97)	≥ 95%, as determined by reducing SDS-PAGE.

S100A10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80889	S100A10 Antibody (YA675)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P80889A	S100A10 Antibody (YA675)(PBS only)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P84419	S100A10/P11 Antibody (YA4116)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P84419A	S100A10/P11 Antibody (YA4116)(PBS only)	WB, IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Trachea Leiomyoma	Tracheal Neoplasms Leiomyoma Of The Trachea Tracheal Neoplasm Tracheal Leiomyoma
Conjunctival Intraepithelial Neoplasm	Intraepithelial Neoplasia Of Conjunctiva Conjunctival Intraepithelial Neoplasia
Barrett'S Adenocarcinoma	Barrett Adenocarcinoma Adenocarcinoma Arising In Barrett'S Mucosa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136465	A2ti-1	Inhibitor	99.78%	Unkown
HY-136466	A2ti-2	Inhibitor	99.80%	Unkown
HY-RS12372	S100A10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16798	S100a10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23239	S100a10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	S100A10	MGD	MGI:1339468
Rattus norvegicus	S100A10	RGD	RGD:628655
Bos taurus	S100A10	VGNC	VGNC:34237
Felis catus	S100A10	VGNC	VGNC:80348
Macaca mulatta	S100A10	VGNC	VGNC:106491
Others	S100A10	NCBI