1. Anti-infection
  2. Virus Protease
  3. A2ti-2

A2ti-2 

Cat. No.: HY-136466
Handling Instructions

A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection.

For research use only. We do not sell to patients.

A2ti-2 Chemical Structure

A2ti-2 Chemical Structure

CAS No. : 482646-13-9

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Description

A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM[1]. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection[2].

IC50 & Target

IC50: 230 μM (A2t)[1]

In Vitro

A2ti-2 (compound 7a) is an annexin A2-S100A10 protein-protein interaction blocker[1].
A2ti-2 is less effective with <50% reduction in HPV16 PsV infection achieved at 100 μM. A2ti-1 decreases HPV16 entry with a 20% reduction at 100 μM[2].

Molecular Weight

354.43

Formula

C₁₈H₁₈N₄O₂S

CAS No.

482646-13-9

SMILES

O=C(N)CSC1=NN=C(COC2=CC=CC=C2C)N1C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

A2ti-2Virus ProteaseannexinA2S100A10heterotetramerA2tprotein-proteininteractionPPIhumanpapillomavirustype16HPV16HPVInhibitorinhibitorinhibit

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