1. Anti-infection
  2. Virus Protease
  3. A2ti-2

A2ti-2 

Cat. No.: HY-136466 Purity: 99.85%
Handling Instructions

A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection.

For research use only. We do not sell to patients.

A2ti-2 Chemical Structure

A2ti-2 Chemical Structure

CAS No. : 482646-13-9

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10 mM * 1 mL in DMSO Check price and availability
5 mg Check price and availability
10 mg Check price and availability
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Description

A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM[1]. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection[2].

IC50 & Target

IC50: 230 μM (A2t)[1]

In Vitro

A2ti-2 (compound 7a) is an annexin A2-S100A10 protein-protein interaction blocker[1].
A2ti-2 is less effective with <50% reduction in HPV16 PsV infection achieved at 100 μM. A2ti-1 decreases HPV16 entry with a 20% reduction at 100 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

354.43

Formula

C₁₈H₁₈N₄O₂S

CAS No.

482646-13-9

SMILES

O=C(N)CSC1=NN=C(COC2=CC=CC=C2C)N1C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (705.36 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8214 mL 14.1072 mL 28.2143 mL
5 mM 0.5643 mL 2.8214 mL 5.6429 mL
10 mM 0.2821 mL 1.4107 mL 2.8214 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

A2ti-2Virus ProteaseannexinA2S100A10heterotetramerA2tprotein-proteininteractionPPIhumanpapillomavirustype16HPV16HPVInhibitorinhibitorinhibit

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A2ti-2
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