482646-13-9
482646-13-9
Chemical Structure
A2ti-2
- CAS No.: 482646-13-9
- Formula:C18H18N4O2S
- Molecular Weight:354.43
IUPAC Name: 2-((4-phenyl-5-((o-tolyloxy)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
InChIKey: DRZJLOOZLBTLAL-UHFFFAOYSA-N
SMILES: O=C(N)CSC1=NN=C(COC2=CC=CC=C2C)N1C3=CC=CC=C3
Biological Activity: A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM[1]. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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A2ti-2 | 99.80% | A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection. | ||||||||||||||||||||
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References
- [1]. Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7(8):1435-46. [Content Brief]
- [2]. Andrew W Woodham, et al. Small Molecule Inhibitors of the Annexin A2 Heterotetramer Prevent Human Papillomavirus Type 16 Infection. J Antimicrob Chemother. 2015;70(6):1686-90. [Content Brief]
Keywords
