10 Results for "

Protoberberine

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "Protoberberine" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-N6865
CAS No.: 38691-95-1
Groenlandicine, a protoberberine alkaloid, is a cholinesterase inhibitor (AChE (IC50 = 0.54 μM), BChE (IC50 = 3.32 μM)). Groenlandicine non-competitively inhibits BACE1 (IC50 = 19.68 μM, Ki = 21.2) and inhibits RLAR (IC50 = 140.1 μM), HRAR (IC50 = 154.2 μM), and total ROS generation (IC50 = 51.78 μM) in vitro. Groenlandicine suppresses osteosarcoma cell proliferation while promoting apoptosis. Groenlandicine inhibits the tumor growth when combined with Cisplatin (HY-17394). Groenlandicine can be used for the study on osteosarcoma, Alzheimer's disease and diabetes mellitus .
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1
1 Cited Publications
Cat. No.: HY-118581
CAS No.: 38989-38-7
Purity:  98.30%
Target:  

Topoisomerase

Research Areas:  

Cancer

Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage . Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes .
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Cat. No.: HY-163459
CAS No.: 908001-51-4
Target:  

Fungal

Research Areas:  

Infection

HWY-289 is a semisynthetic protoberberine derivative, has broad-spectrum and potent activities against phytopathogenic fungi, particularly Botrytis cinerea (EC50 = 1.34 μg/mL). HWY-289 changes the morphology of the mycelium and the internal structure of cells. HWY-289 reduces ATP content, ATPase activities, and key enzyme activities in the TCA cycle .
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Cat. No.: HY-N8346
CAS No.: 19716-61-1
8-Oxocoptisine is a natural protoberberine alkaloid with anti-cancer activity .
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Cat. No.: HY-N7642
CAS No.: 548-30-1
Synonyms: Hydroxysanguinarine; 8-Oxosanguinarine
Oxysanguinarine (Hydroxysanguinarine;8-Oxosanguinarine) is a protoberberine alkaloid from Meconopsis simplicifolia with antimalarial activity .
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Cat. No.: HY-N6957
CAS No.: 81397-08-2
Target:  

Drug Derivative

Research Areas:  

Metabolic Disease

8-Keto-berberine (compound 29) is a non-naturally occurring 11, 12-oxygenated protoberberine derived from naturally occurring 9, 10-oxygenated protoberberine .
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Cat. No.: HY-E71130
Research Areas:  

Others

The product of the (S)-Scoulerine 9-O-methyltransferase (EC 2.1.1.117) reaction is a precursor of the protoberberine alkaloid in plants.
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Cat. No.: HY-E71131
Research Areas:  

Others

(S)-Stylopine synthase (EC 1.14.21.1) catalyzes an oxidation reaction that does not introduce oxygen into the product. (S)-Stylopine synthase (EC 1.14.21.1) forms a second methylenedioxy bridge in the protoberberine alkaloid stylopine by oxidatively cyclizing cheilanthifoline with adjacent phenolic hydroxyl and methoxy groups.
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Cat. No.: HY-E71128
Research Areas:  

Others

(S)-Nandinine synthase (EC 1.14.21.12) is a cytochrome P-450 heme-thiolate enzyme catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid (S)-Nandinine by the oxidative ring closure of adjacent phenolic and methoxy groups of (S)-Scoulerine.
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Cat. No.: HY-N18128
CAS No.: 490-52-8
Hunnemanine is a protoberberine-type isoquinoline alkaloid with significant antifungal activity. At a concentration of 1000 ppm, Hunnemanine completely inhibits spore germination of a variety of phytopathogenic fungi, including Alternaria brassicae, Helminthosporium pennisetti, and Fusarium lini. Hunnemanine can be applied to studies on the infection mechanisms of phytopathogenic fungi and related control strategies .
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