2 Results for "

Questiomycin A

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Questiomycin A" in MCE Product Catalog:

Cat. No.: HY-N8439
CAS No.: 1916-59-2
Synonyms: Phx-3
Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases .
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Cat. No.: HY-181008
Target:  

Bacterial

Research Areas:  

Infection Inflammation/Immunology

Antitubercular agent-56, a Questiomycin A (HY-N8439) derivative, is a potent and orally active antitubercular agent. Antitubercular agent-56 disrupts mycobacterial envelope integrity by inhibiting FabD (Kd = 9.39 μM; IC50 = 49.60 μM). Antitubercular agent-56 exhibits good intracellular antimycobacterial activity against Mycobacterium tuberculosis (MTB) and drug-resistant MTB both in vitro and in vivo. Antitubercular agent-56 can be used for research on tuberculosis (TB) .
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