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REV7

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (4) Reference Standards (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (4)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: REV-ERB

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126214

JH-RE-06 4 Publications Verification	DNA/RNA Synthesis	Cancer
JH-RE-06, a potent *REV1-REV7* interface inhibitor (IC₅₀=0.78 μM; K_d=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy .

HY-100468

REV7/REV3L-IN-1 1 Publications Verification	DNA/RNA Synthesis	Cancer
REV7/REV3L-IN-1 is a *REV7/REV3L* interaction inhibitor with an IC₅₀ of 78 μM. REV7/REV3L-IN-1 binds directly to *REV7* and inhibits its interaction with *REV3L. REV7/REV3L-IN-1* inhibits interstrand crosslink repair in cells. REV7/REV3L-IN-1 chemosensitizes cancer cells to Cisplatin (HY-17394). REV7/REV3L-IN-1 can be used in cervical cancer research .

HY-126214S

JH-RE-06-d6	DNA/RNA Synthesis	Cancer
JH-RE-06-d6 is deuterium labele JH-RE-06. JH-RE-06, a potent REV1-REV7 interface inhibitor (IC₅₀=0.78 μM; K_i=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy .

HY-100468R

REV7/REV3L-IN-1 (Standard)	Reference Standards DNA/RNA Synthesis	Cancer
REV7/REV3L-IN-1 (Standard) is the analytical standard of REV7/REV3L-IN-1 (HY-100468). This product is intended for research and analytical applications. REV7/REV3L-IN-1 is a *REV7/REV3L* interaction inhibitor with an IC₅₀ of 78 μM. REV7/REV3L-IN-1 binds directly to *REV7* and inhibits its interaction with *REV3L. REV7/REV3L-IN-1* inhibits interstrand crosslink repair in cells. REV7/REV3L-IN-1 chemosensitizes cancer cells to Cisplatin (HY-17394). REV7/REV3L-IN-1 can be used in cervical cancer research .

HY-RS07951

MAD2L2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAD2L2 Human Pre-designed siRNA Set A contains three designed siRNAs for MAD2L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAD2L2 Human Pre-designed siRNA Set A MAD2L2 Human Pre-designed siRNA Set A

HY-RS19788

Mad2l2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mad2l2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mad2l2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mad2l2 Mouse Pre-designed siRNA Set A Mad2l2 Mouse Pre-designed siRNA Set A

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71540

	MAD2L1 Protein, Human (His-SUMO) 1 Publications Verification HsMAD2; MAD 2; MAD2 like 1; MAD2 mitotic arrest deficient like 1; MAD2-like protein 1; Mad2l1; MD2L1_HUMAN; Mitotic arrest deficient 2-like protein 1; Mitotic spindle assembly checkpoint protein MAD2A; REV7	Human	E. coli
	MAD2L1 is a critical spindle assembly checkpoint component that delays anaphase until correct chromosome alignment. During prophase, it forms a heterotetrameric complex with MAD1L1 at unattached kinetochores, recruiting O-MAD2 and aiding transformation. MAD2L1 Protein, Human (His-SUMO) is the recombinant human-derived MAD2L1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-126214S

JH-RE-06-d6
JH-RE-06-d6 is deuterium labele JH-RE-06. JH-RE-06, a potent REV1-REV7 interface inhibitor (IC₅₀=0.78 μM; K_i=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy .

Host:	Rabbit (3)
Reactivity:	Human (3) Rat (1) Mouse (1)
Application:	IHC-P (1) ICC/IF (2) IP (3) WB (3) FC (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83445

	MAD2L2 Antibody (YA3190) REV7; FANCV; MAD2B; POLZ2	WB, ICC/IF, IP	Human
	MAD2L2 Antibody (YA3190) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAD2L2.

HY-P83445A

	MAD2L2 Antibody (YA3190)(PBS only) REV7; FANCV; MAD2B; POLZ2	WB, ICC/IF, IP	Human
	MAD2L2 Antibody (YA3190) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAD2L2.

HY-P810361

	MAD2L2 Antibody (YA9683) Homolog of REV7 S ceREVisiae, hREV7, MAD2 (mitotic arrest deficient yeast, homolog) like 2, MAD2 homolog, MAD2 like 2, MAD2 mitotic arrest deficient like 2, MAD2-like protein 2, MAD2B, Mad2l2, MD2L2_HUMAN	WB, IHC-P, FC, IP	Human, Mouse, Rat
	MAD2L2 Antibody (YA9683) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to MAD2L2.

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MAD2L2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MAD2L2 Human Pre-designed siRNA Set A contains three designed siRNAs for MAD2L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mad2l2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Mad2l2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mad2l2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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