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Results for "

RyR1

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

3

Peptides

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12542
    Dantrolene
    Maximum Cited Publications
    15 Publications Verification

    F 368

    		 Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene is also a calcium channel protein inhibitor. Dantrolene inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] .
    Dantrolene
  • HY-14657
    Dantrolene sodium
    Maximum Cited Publications
    15 Publications Verification

    F 440

    		 Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Cardiovascular Disease Neurological Disease Metabolic Disease
    Dantrolene sodium is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene sodium is also a calcium channel protein inhibitor. Dantrolene sodium inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] .
    Dantrolene sodium
  • HY-12542A
    Dantrolene sodium hemiheptahydrate
    Maximum Cited Publications
    15 Publications Verification

    Dantrolene sodium hydrate

    		 Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Cardiovascular Disease Neurological Disease Metabolic Disease
    Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene sodium hemiheptahydrate is also a calcium channel protein inhibitor. Dantrolene sodium hemiheptahydrate inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium hemiheptahydrate offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] .
    Dantrolene sodium hemiheptahydrate
  • HY-119850
    Aladorian

    ARM036; S44121

    		 Calcium Channel Cardiovascular Disease
    Aladorian (ARM036; S44121) is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian improves cardiomyocyte Ca²⁺ homeostasis independent of dystrophin restoration. Aladorian attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy [1] .
    Aladorian
  • HY-149662
    TMDJ-035

    		Calcium Channel ATP Synthase Myosin Cardiovascular Disease
    TMDJ-035 is a high-affinity, selective RyR2 inhibitor with an EC50 of 0.0130 μM. TMDJ-035 reduces RyR2 protein expression without affecting action potential-induced Ca 2+ transients. TMDJ-035 decreases ATP content and intracellular Ca 2+ levels. TMDJ-035 inhibits arrhythmias in a CPVT mouse model carrying mutant RyR2s. TMDJ-035 has no effect on electrocardiogram parameters or cardiac systolic function. TMDJ-035 exacerbates heart failure in mouse myocardial infarction models and hypoxic cardiomyocytes by altering cardiac function, causing tissue damage, promoting inflammatory infiltration, collagen deposition, and changes in Myosin heavy chain/actin expression. TMDJ-035 can be used in studies related to heart failure, catecholaminergic polymorphic ventricular tachycardia, and arrhythmias [1] .
    TMDJ-035
  • HY-141564
    RyR1-IN-1

    		Calcium Channel Neurological Disease
    RyR1-IN-1 (Compound 1) is a RyR1 inhibitor with an IC50 of 12 nM. RyR1-IN-1 blocks Ca²⁺ release and inhibits muscle tetany caused by caffeine and heat stress. RyR1-IN-1 can completely prevent the increase in body temperature and death caused by isoflurane and heat stress. RyR1-IN-1 can be used for the study of heat stroke [1].
    RyR1-IN-1
  • HY-RS12368
    RYR1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    RYR1 Human Pre-designed siRNA Set A contains three designed siRNAs for RYR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RYR1 Human Pre-designed siRNA Set A
    RYR1 Human Pre-designed siRNA Set A
  • HY-P5114A
    Maurocalcine TFA

    		Calcium Channel Others
    Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine TFA induces [ 3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine TFA exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine TFA can be applied to in vivo cell tracking or other cell imaging techniques [1] .
    Maurocalcine TFA
  • HY-RS26452
    Ryr1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ryr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ryr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ryr1 Rat Pre-designed siRNA Set A
    Ryr1 Rat Pre-designed siRNA Set A
  • HY-RS19950
    Ryr1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ryr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ryr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ryr1 Mouse Pre-designed siRNA Set A
    Ryr1 Mouse Pre-designed siRNA Set A
  • HY-P5424
    RyR1(3614-3643)

    		Calmodulin Others
    RyR1(3614-3643) is a biological active peptide. (the absolutely conserved peptide corresponding to the CaM-binding domain of RyR1 in all vertebrates)
    RyR1(3614-3643)
  • HY-178437
    Bastadins-5

    		Calcium Channel Metabolic Disease
    Bastadins-5 is a potent stabilizer for the open state of RYR1. Bastadins-5 enhances Ca 2+-induced Ca 2+ release. Bastadins-5 can be used in research on central nuclear disease and malignant hypothermia [1].
    Bastadins-5
  • HY-P5114
    Maurocalcine

    		Calcium Channel Others
    Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [ 3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques [1] .
    Maurocalcine
  • HY-119581
    MBED

    9-Methyl-7-bromoeudistomin D

    		 Fluorescent Dye Neurological Disease
    MBED (9-Methyl-7-bromoeudistomin D) is a RyR agonist. MBED is a high-affinity caffeine-like probe, helps identify the caffeine-binding site in RyRs .
    MBED

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