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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
RyR1
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "RyR1" in MCE Product Catalog:
19
19 Publications Verification
Synonyms: F 368
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene is also a calcium channel protein inhibitor. Dantrolene inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] .
19
19 Publications Verification
Synonyms: F 440
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Metabolic Disease
Dantrolene sodium is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene sodium is also a calcium channel protein inhibitor. Dantrolene sodium inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] .
19
19 Publications Verification
Synonyms: Dantrolene sodium hydrate
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Metabolic Disease
Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 μM and an IC50 of 52.3 μM. Dantrolene sodium hemiheptahydrate is also a calcium channel protein inhibitor. Dantrolene sodium hemiheptahydrate inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium hemiheptahydrate offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] .
Art. -Nr.: HY-141564
CAS. Nr.: 2837939-81-6
Target:
Forschungsgebiete:
RyR1-IN-1 (Compound 1) is a RyR1 inhibitor with an IC50 of 12 nM. RyR1-IN-1 blocks Ca²⁺ release and inhibits muscle tetany caused by caffeine and heat stress. RyR1-IN-1 can completely prevent the increase in body temperature and death caused by isoflurane and heat stress. RyR1-IN-1 can be used for the study of heat stroke [1].
Art. -Nr.: HY-RS12368
Target:
Forschungsgebiete:
RYR1 Human Pre-designed siRNA Set A contains three designed siRNAs for RYR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-P5114A
Target:
Forschungsgebiete:
Art. -Nr.: HY-RS26452
Target:
Forschungsgebiete:
Ryr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ryr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS19950
Target:
Forschungsgebiete:
Ryr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ryr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-P5424
Target:
Forschungsgebiete:
Art. -Nr.: HY-178437
CAS. Nr.: 79067-75-7
Target:
Forschungsgebiete:
Bastadins-5 is a potent stabilizer for the open state of RYR1. Bastadins-5 enhances Ca 2+-induced Ca 2+ release. Bastadins-5 can be used in research on central nuclear disease and malignant hypothermia [1].
Art. -Nr.: HY-P5114
CAS. Nr.: 269745-22-4
Target:
Forschungsgebiete:
Art. -Nr.: HY-119581
CAS. Nr.: 123363-40-6
Synonyms: 9-Methyl-7-bromoeudistomin D
Target:
Forschungsgebiete:
MBED (9-Methyl-7-bromoeudistomin D) is a RyR agonist. MBED is a high-affinity caffeine-like probe, helps identify the caffeine-binding site in RyRs .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
