123363-40-6
123363-40-6
Chemical Structure
MBED
Synonym(s): 9-Methyl-7-bromoeudistomin D
- CAS No.: 123363-40-6
- Formula:C12H8Br2N2O
- Molecular Weight:356.01
IUPAC Name: 5,7-dibromo-9-methyl-9H-pyrido[3,4-b]indol-6-ol
InChIKey: BFWFPORISPXHAR-UHFFFAOYSA-N
SMILES: OC1=C(C2=C(C=C1Br)N(C3=C2C=CN=C3)C)Br
Biological Activity: MBED (9-Methyl-7-bromoeudistomin D) is a RyR agonist. MBED is a high-affinity caffeine-like probe, helps identify the caffeine-binding site in RyRs[1][2].
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MBED | MBED (9-Methyl-7-bromoeudistomin D) is a RyR agonist. MBED is a high-affinity caffeine-like probe, helps identify the caffeine-binding site in RyRs. | |||||||||||||||||||||
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References
- [1]. Diaz-Sylvester PL, et al. Eudistomin D and penaresin derivatives as modulators of ryanodine receptor channels and sarcoplasmic reticulum Ca2+ ATPase in striated muscle. Mol Pharmacol. 2014 Apr;85(4):564-75. [Content Brief]
- [2]. Mirko Vukcevic, et al. Downstream Effects of a RyR1 Mutation Linked to Malignant Hyperthermia on the Phenotypic and Functional Characteristic of Dendritic Cells. Volume 102, Issue 3, Supplement 1307aJanuary 31, 2012.
