865433-00-7
Chemical Structure
Aladorian
Synonym(s): ARM036; S44121
- CAS No.: 865433-00-7
- Formula:C12H13NO4S
- Molecular Weight:267.30
IUPAC Name: 2-(7-methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)-2-oxoacetic acid
InChIKey: FPWBHFYYVSNIFZ-UHFFFAOYSA-N
SMILES: O=C(C(N1CCSC2=CC=C(C=C2C1)OC)=O)O
Biological Activity: Aladorian (ARM036; S44121) is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian improves cardiomyocyte Ca²⁺ homeostasis independent of dystrophin restoration. Aladorian attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy[1][2][3][4][5].
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Aladorian | 99.31% | Aladorian (ARM036; S44121) is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian improves cardiomyocyte Ca²⁺ homeostasis independent of dystrophin restoration. Aladorian attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy. | ||||||||||||||||||||
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- [1]. Luo M, et al. Mechanisms of altered Ca²⁺ handling in heart failure. Circ Res. 2013;113(6):690-708. [Content Brief]
- [2]. Kupatt C, et al. Ryanodine Receptors Matter for Cardiac Function in Duchenne Muscular Dystrophy: Stability First. J Am Coll Cardiol. 2021 Dec 14;78(24):2454-2456. [Content Brief]
- [3]. Thireau J, et al. Anti-arrhythmic Effect of a Novel Rycal, S44121/Arm036, in a Post-myocardial Infarction Mouse Model of Heart Failure. Circulation. 2014;130( Suppl 2 ):Abstract 18592.
- [4]. Pauly M, et al. The Ryanodine Receptor Stabilizer S44121/Arm036 Improves Peripheral and Respiratory Muscle Function in a Mouse Model of Heart Failure. Circulation. 2014;130( Suppl 2 ):Abstract 13726.
- [5]. Thevis M, et al. Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls. J Pharm Biomed Anal. 2014;101:66-83. [Content Brief]
Keywords
