Maurocalcine
Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques.
For research use only. We do not sell to patients.
- CAS No.: 269745-22-4
- Formula: C156H270N56O46S6
- Molecular Weight:3858.55
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Calcium Channel Isoforms
More
Biological Activity
Maurocalcine (100 nM, 24 h) increases the sensitivity of RyR2 to activating [Ca2+]i and decrease its sensitivity to inhibiting [Ca2+]i[1].
Maurocalcine (5 μM, 4 h/24 h) is absolutely no sign of significant cell toxicity for HEK293[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HEK293
-
Concentration:5, 10 μM
-
Incubation Time:4, 24 h
-
Result:Had absolutely no sign of significant cell toxicity for concentrations up to 5 μM whether the incubation time lasted 4 h or 24 h.
Exhibited only 8.0% cell toxicity for concentration of 10 μM and a 24 h incubation time.
Chemical Information
-
CAS No. 269745-22-4
-
Molecular Weight 3858.55
-
Formula C156H270N56O46S6
-
Sequence
Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Leu-Cys-Lys-Glu-Asn-Lys-Asp-Cys-Cys-Ser-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ile-Glu-Lys-Arg-Cys-Arg (Disulfide bridge:Cys3-Cys17;Cys10-Cys21;Cys16-Cys32)
-
Sequence Shortening
GDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR (Disulfide bridge:Cys3-Cys17;Cys10-Cys21;Cys16-Cys32)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. De Waard S, et al. Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes. Biochem J. 2020 Oct 30;477(20):3985-3999. [Content Brief]
[2]. Altafaj X, et al. Maurocalcine interacts with the cardiac ryanodine receptor without inducing channel modification. Biochem J. 2007 Sep 1;406(2):309-15. [Content Brief]
[3]. Boisseau S, et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta. 2006 Mar;1758(3):308-19. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Maurocalcine Related Classifications
HY-P5114 Related Classifications
Powered by Bioz