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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
SH3+domain
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "SH3+domain" in MCE Product Catalog:
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3 Cited Publications
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AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
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3 Cited Publications
Target:
Research Areas:
AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
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1 Cited Publications
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Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis .
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1 Cited Publications
Cat. No.: HY-P76687
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBASH3A; Ubiquitin Associated And SH3 Domain Containing A; STS‑2; CLIP4; TULA; Ubiquitin‑Associated And SH3 Domain‑Containing Protein A; Suppressor Of T‑Cell Receptor Signaling 2; T‑Cell Ubiquitin Ligand Protein; T‑Cell Ubiquitin Ligand 1; Cbl‑Interacting
Cat. No.: HY-163144
CAS No.: 3044084-97-8
DAS-5-oCRBN is a PROTAC molecule with both c‑Src kinase inhibitory activity and target protein degradation activity, with an EC50 of 45 nM for c‑Src binding. DAS-5-oCRBN binds non-covalently to Cereblon and mediates target protein degradation via the ubiquitin-proteasome pathway. DAS-5-oCRBN can catalytically deplete intracellular c‑Src protein, while blocking both the kinase catalytic function of c‑Src and the non-catalytic protein interactions mediated by its SH2 and SH3 domains. DAS-5-oCRBN inhibits tumor cell proliferation and exerts significant anti-proliferative effects on both c‑Src kinase activity-dependent MDA-MB-231 cells and c‑Src protein level-dependent CAL51 cells. DAS-5-oCRBN can be used in cancer-related research such as studies on triple-negative breast cancer and chronic myeloid leukemia .
Cat. No.: HY-180888
CAS No.: 1356734-45-6
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Lck-IN-5 (example C10) is a potent and selective lymphocyte-specific protein tyrosine kinase (LCK) inhibitor. Lck-IN-5 selectively disrupts the interaction between the SH3 domain of LCK and the RK motif of CD3ε, thereby impairing LCK recruitment to the TCR. Lck-IN-5 modulates the activity of CD3ε-containing CAR and TRuC T cells, attenuating cytokine production and promoting a central-memory-like phenotype associated with enhanced persistence. Lck-IN-5 can be used for autoimmune diseases and graft-versus-host disease research .
Cat. No.: HY-113817
CAS No.: 1000010-33-2
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SHIP1 activator 1 is an SH3 domain-containing inositol 5-phosphatase regulator with SHIP1 activating activity. SHIP1 activator 1 retains its SHIA-1 activating ability by removing unnecessary functional groups. SHIP1 activator 1 is able to activate SHIP1 in vitro, inhibit Akt phosphorylation in MOLT-4 cells, and show dose-dependent activity in a mouse model of inflammation. SHIP1 activator 1 is an important chemical tool for evaluating the potential of SHIP1 activators as inhibitors of hematopoietic diseases involving abnormal PI3K cell signaling .
Cat. No.: HY-P77099
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NCKIPSD; Diaphanous Protein Interacting Protein; NCK Interacting Protein With SH3 Domain; 54 KDa Vimentin-Interacting Protein; AF3P21; WASP-Interacting SH3-Domain Protein; SPIN90; 54 KDa VacA-Interacting Protein; WISH; SH3 Adapter Protein SPIN90; WASLBP;
Cat. No.: HY-P701776
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SBK3; Putative Serine/Threonine-Protein Kinase SBK3; SH3 Domain Binding Kinase Family Member 3; SH3 Domain Binding Kinase Family, Member 3; SgK110; SH3-Binding Domain Kinase Family Member 3; Uncharacterized Serine/Threonine-Protein Kinase SBK3; SH3 Domain
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Cat. No.: HY-P705882
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: SBK1; Sbk; SH3 Domain Binding Kinase 1; SH3-Binding Domain Kinase 1; Serine/Threonine-Protein Kinase SBK1; SH3 Domain-Binding Kinase 1
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Cat. No.: HY-P703483
Synonyms: SBK2; Sugen Kinase 69; SH3 Domain Binding Kinase Family Member 2; SH3 Domain Binding Kinase Family, Member 2; SGK069; SH3 Domain-Binding Kinase Family Member 2; Serine/Threonine-Protein Kinase SBK2; SgK069; SH3-Binding Domain Kinase Family, Member 2
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Cat. No.: HY-P701477
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STAMBPL1; Associated Molecule With The SH3 Domain Of STAM (AMSH) - Family Protein; STAM Binding Protein Like 1; Associated Molecule With The SH3 Domain Of STAM (AMSH) Like Protein; AMSH-LP; AMSH-Like Protease; BA399O19.2; FLJ31524; KIAA1373; STAM Binding
Cat. No.: HY-P701459
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STAMBPL1; Associated Molecule With The SH3 Domain Of STAM (AMSH) - Family Protein; STAM Binding Protein Like 1; Associated Molecule With The SH3 Domain Of STAM (AMSH) Like Protein; AMSH-LP; AMSH-Like Protease; BA399O19.2; FLJ31524; KIAA1373; STAM Binding
Cat. No.: HY-P705439
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: SORBS2; Arg-Binding Protein 2; Sorbin And SH3 Domain Containing 2; Arg/Abl Interacting Protein; ARGBP2; Arg Binding Protein 2; Sorbin And SH3 Domain-Containing Protein 2; PRO0618; KIAA0777; Sorbin; Arg/Abl-Interacting Protein 2; ArgBP2
Cat. No.: HY-P70846A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MIA; Melanoma-Derived Growth Regulatory Protein; MIA SH3 Domain Containing; Melanoma Inhibitory Activity; CD-RAP; Melanoma Inhibitory Activity Protein; MIA1
Cat. No.: HY-107390AR
CAS No.: 1704801-24-0
Research Areas:
AX-024 hydrochloride (Standard) is the analytical standard of AX-024 (hydrochloride) (HY-107390A). This product is intended for research and analytical applications. AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
