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Results for "

SSR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Bradykinin Receptor (1) CFTR (5) Dopamine Receptor (1) Drug Derivative (1) Drug Metabolite (1) Elastase (1) Endogenous Metabolite (1) FAAH (1) FGFR (2) Fungal (1) GABA Receptor (1) GlyT (3) Mitochondrial Metabolism (1) nAChR (1) Neurokinin Receptor (3) Oxytocin Receptor (1) Parasite (2) Reference Standards (2) Small Interfering RNA (siRNA) (6) Succinate Dehydrogenase (1) Thrombin (1) Vasopressin Receptor (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (5) Endocrinology (3) Infection (3) Inflammation/Immunology (2) Metabolic Disease (6) Neurological Disease (11)
Click Chemistry:	Alkynes (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (4) siRNAs (6)

Inhibitors & Agonists

Fluorescent Dye

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-106203

Crinecerfont SSR-125543	CFTR	Metabolic Disease
Crinecerfont (SSR-125543) is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency . Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10066

Nelivaptan 1 Publications Verification SSR-149415	Vasopressin Receptor	Cardiovascular Disease Neurological Disease
Nelivaptan (SSR-149415) is a selective and orally active vasopressin V_1b receptor antagonist (K_i: 3.7 and 1.3 nM for native and recombinant rat V_1b receptors, respectively). Nelivaptan inhibits arginine vasopressin (AVP)-induced Ca ²⁺ increase and corticotropin secretion. Nelivaptan can be used for research of stress, anxiety and depression .

HY-103445

SSR69071	Elastase	Cardiovascular Disease
SSR69071 is a potent, orally active and selective inhibitor of neutrophil elastase. SSR69071 reduces myocardial infarct size following ischemia-reperfusion injury . SSR69071 displays a higher affinity for human elastase (K_i=0.0168 nM) than for rat (K_i=3 nM), mouse (K_i=1.8 nM), and rabbit (K_i= 58 nM) elastases .

HY-106203A

Crinecerfont hydrochloride SSR-125543 hydrochloride	CFTR	Metabolic Disease
Crinecerfont (SSR-125543) hydrochloride is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont hydrochloride blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont hydrochloride improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont hydrochloride can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency . Crinecerfont hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15039

SSR240612	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology Endocrinology
SSR240612 is a potent, and orally active specific non-peptide bradykinin B1 receptor antagonist, with K_is of 0.48 nM and 0.73 nM for B1 kinin receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 481 nM and 358 nM for B2 receptors of guinea pig ileum membranes and CHO cells expressing human B1 receptor, respectively.

HY-19364

Ferroquine 1 Publications Verification Ferrochloroquine; SSR97193	Parasite	Infection
Ferroquine (Ferrochloroquine), a ferrocenyl analogue of Chloroquine, is an antimalarial agent. Ferroquine shows parasiticidal effect on *Plasmodium* by inducing oxidative stress and the subsequent destruction of the membrane .

HY-15599

SSR128129E 1 Publications Verification SSR	FGFR	Cancer
SSR128129E is an orally available and allosteric FGFR inhibitor with an IC₅₀ of 1.9 μM for FGFR1.

HY-19411

SSR180711 hydrochloride	nAChR	Neurological Disease
SSR180711 hydrochloride is an orally active, selective and reversible α7 acetylcholine nicotinic receptor (n-AChRs) partial agonist. SSR180711 hydrochloride can act on rat α7 n-AChR (K_i=22 nM; IC₅₀=30 nM) and human α7 n-AChR (K_i=14 nM; IC₅₀=18 nM). SSR180711 hydrochloride increases glutamatergic neurotransmission, ACh release and long-term potentiation (LTP) in the hippocampus .

HY-123863

SSR411298	FAAH	Neurological Disease
SSR411298 is an orally active, selective and reversible fatty acid amide hydrolase (FAAH) inhibitor. SSR411298 has the potential for post-traumatic stress disorder research .

HY-10715

SSR504734	GlyT	Neurological Disease
SSR504734 is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 (IC₅₀=18, 15, and 38 nM, respectively). SSR504734 shows anti-schizophrenia, anti-anxiety and anti-depression activities .

HY-19372

SSR-181507 hydrochloride	Dopamine Receptor 5-HT Receptor	Neurological Disease
SSR-181507 hydrochloride is a dopamine D₂ receptor antagonist and 5-HT_1A receptor agonist. SSR-181507 antagonizes Apomorphine (HY-12723)-induced climbing in mice and stereotypies in rats. SSR-181507 hydrochloride can be used in the research of depression and anxiety .

HY-116822

SSR 146977	Neurokinin Receptor	Neurological Disease
SSR 146977 is a potent and selective antagonist of the tachykinin NK3 receptor. SSR 146977 inhibits the binding of radioactive neurokinin B to NK3 receptors in Chinese hamster ovary cells, with a K_i of 0.26 nM .

HY-135847

Desmethyl ferroquine SSR97213	Parasite Drug Metabolite	Infection
Desmethyl ferroquine (SSR97213) is the active and major metabolite of Ferroquine. Ferroquine is an antimalarial. Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains .

HY-RS19959

Ssr1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ssr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ssr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ssr1 Mouse Pre-designed siRNA Set A Ssr1 Mouse Pre-designed siRNA Set A

HY-19456

SSR-241586	Neurokinin Receptor	Neurological Disease Endocrinology
SSR-241586 is an antagonist of neurokinin receptors. SSR-241586 is shown to be active in the treatment of depression, schizophrenia, urinary trouble, emesis, and irritable bowel syndrome (IBS) .

HY-107693

SSR 146977 hydrochloride	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
SSR 146977 hydrochloride is a potent and selective antagonist of the tachykinin NK₃ receptor. SSR 146977 hydrochloride can be used in the study of psychiatric disorders and airway inflammation .

HY-19674

SSR182289 SSR182289A free base	Thrombin	Cardiovascular Disease
SSR182289 (SSR182289A free base) is a selective and potent orally active thrombin inhibitor. SSR182289 competitively and selectivity inhibits human thrombin (K_i=0.031 μM). SSR182289 demonstrates anticoagulant activity in vitro (thrombin time EC₁₀₀=96 nM) and inhibits tissue factor-induced thrombin generation (IC₅₀=0.15 μM) in human plasma. SSR182289 inhibits thrombin-induced aggregation of human platelets (IC₅₀=32 nM), but has no effect on aggregation induced by other platelet agonists .

HY-167824

SSR180711	Endogenous Metabolite	Neurological Disease
SSR180711 is a potent and subtype-selective α7 agonist with activity in Alzheimer's disease and schizophrenia research. SSR180711 can be used to study subtypes of intracerebral hemorrhage associated with cerebral small vessel disease. SSR180711 shows potential in electrophysiological and behavioral studies to evaluate its effects on cognitive function. SSR180711 also has potential for studying cerebrovascular lesions and their effects .

HY-15599A

SSR128129E free acid SSR free acid	FGFR	Cancer
SSR128129E free acid is an orally available and allosteric FGFR inhibitor with an IC₅₀ of 1.9 μM for FGFR1.

HY-114895

SSR504734 free base	GlyT	Neurological Disease
SSR504734 free base is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 (IC₅₀=18, 15, and 38 nM, respectively). SSR504734 free base shows anti-schizophrenia, anti-anxiety and anti-depression activities .

HY-RS13814

SSR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SSR1 Human Pre-designed siRNA Set A contains three designed siRNAs for SSR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SSR1 Human Pre-designed siRNA Set A SSR1 Human Pre-designed siRNA Set A

HY-RS13817

SSR4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SSR4 Human Pre-designed siRNA Set A contains three designed siRNAs for SSR4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SSR4 Human Pre-designed siRNA Set A SSR4 Human Pre-designed siRNA Set A

HY-RS13815

SSR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SSR2 Human Pre-designed siRNA Set A contains three designed siRNAs for SSR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SSR2 Human Pre-designed siRNA Set A SSR2 Human Pre-designed siRNA Set A

HY-RS13816

SSR3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SSR3 Human Pre-designed siRNA Set A contains three designed siRNAs for SSR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SSR3 Human Pre-designed siRNA Set A SSR3 Human Pre-designed siRNA Set A

HY-106207

Celivarone SSR149744C	Drug Derivative	Cardiovascular Disease
Celivarone (SSR149744C) is a orally active noniodinated benzofuran derivative with antiarrhythmic properties. Celivarone has the potential for atrial fibrillation and in ventricular arrhythmias research .

HY-15018A

SSR126768A free base	Oxytocin Receptor	Endocrinology
SSR126768A free base is an orally active antagonist for oxytocin receptor, with K_i of 0.44 nM. SSR126768A free base is a tocolytic agent, that antagonizes the Oxytocin (HY-17571)-induced intracellular Ca ²⁺ increase and prostaglandin release in human uterine smooth muscle cells, inhibits thus the Oxytocin (HY-17571)-induced uterine contraction and delays parturition in pregnant rats in labor .

HY-106203C

Crinecerfont tosylate SSR-125543 tosylate	CFTR	Metabolic Disease
Crinecerfont (SSR-125543) tosylate is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont tosylate blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont tosylate improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont tosylate can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency . Crinecerfont tosylate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-106203B

(R)-Crinecerfont (R)-SSR-125543	CFTR	Metabolic Disease
(R)-Crinecerfont is the R-enantiomer of Crinecerfont (HY-106203). Crinecerfont (SSR-125543) is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency . Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-178050

SDH-IN-30	Fungal Succinate Dehydrogenase	Infection
SDH-IN-30 (Compound 7m) is a Succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 0.34 μM. SDH-IN-30 has potent antifungal activities against Rhizoctonia solani and Sclerotinia sclerotiorum with EC₅₀ s of 0.004 and 0.028 μg/mL. SDH-IN-30 also has remarkable protective and curative efficacies against R. solani and significantly inhibits S. sclerotiorum growth on oilseed rape leaves by damaging the fungal cell structure. SDH-IN-30 can be used for fungal infections like rice sheath blight (RSB) and sclerotinia stem rot (SSR) research .

HY-W436366

SSR180575	GABA Receptor Mitochondrial Metabolism	Cardiovascular Disease
SSR180575 is a specific and potent peripheral benzodiazepine receptor ligand. SSR180575 irreversibly and specifically binds with high affinity on rat heart mitochondria (K_d = 1.95 nM). SSR180575 can be used in the research of cardiovascular diseases .

HY-10715R

SSR504734 (Standard)	Reference Standards GlyT	Neurological Disease
SSR504734 (Standard) is the analytical standard of SSR504734 (HY-10715). This product is intended for research and analytical applications. SSR504734 is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 (IC₅₀=18, 15, and 38 nM, respectively). SSR504734 shows anti-schizophrenia, anti-anxiety and anti-depression activities .

HY-RS26461

Ssr1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ssr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ssr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ssr1 Rat Pre-designed siRNA Set A Ssr1 Rat Pre-designed siRNA Set A

HY-14835

Burapitant SSR240600	Others	Others
Burapitant (SSR240600) is a compound that modulates cholinergic transmission and regulates acetylcholine release in the limbic/prefrontal region of the rat striatum, with its effects being influenced by the interaction of 5-HT? and 5-HT? receptors.

HY-106203R

Crinecerfont (Standard) SSR-125543 (Standard)	Reference Standards CFTR	Metabolic Disease
Crinecerfont (Standard) is the analytical standard of Crinecerfont (HY-106203). This product is intended for research and analytical applications. Crinecerfont (SSR-125543) is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D3085

SSR-LDs

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P77493

	*Somatostatin R1/SSR1 Protein, Human (HEK293, Fc)* Translocon-associated protein subunit alpha; TRAP-alpha; SSR-alpha; TRAPA; PSEC0262	Human	HEK293
	The somatostatin R1 (SSR1) protein contains TRAP-α, TRAP-β, TRAP-δ, and TRAP-gamma, forming a heterotetramer. They play a role in binding calcium to the ER membrane and regulating the retention of ER-resident proteins. Somatostatin R1/SSR1 Protein, Human (HEK293, Fc) is the recombinant human-derived Somatostatin R1/SSR1 protein, expressed by HEK293 , with C-hFc labeled tag.

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Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) WB (4) FC (2)
Isotype:	IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P88097

	SSR1 (TRAP alpha) Antibody (YA7781) TRAPA	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	SSR1 (TRAP alpha) Antibody (YA7781) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SSR1 (TRAP alpha).

HY-P88097A

	SSR1 (TRAP alpha) Antibody (YA7781)(PBS only) TRAPA	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	SSR1 (TRAP alpha) Antibody (YA7781) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SSR1 (TRAP alpha).

HY-P82287

	Somatostatin Receptor 3 Antibody (YA2032) SS3R; SS3-R; SS-3-R; SSR-28	WB	Human
	Somatostatin Receptor 3 Antibody (YA2032) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Somatostatin Receptor 3.

HY-P82287A

	Somatostatin Receptor 3 Antibody (YA2032)(PBS only) SS3R; SS3-R; SS-3-R; SSR-28	WB	Human
	Somatostatin Receptor 3 Antibody (YA2032) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Somatostatin Receptor 3.

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Cat. No.	Product Name		Classification

HY-106203

Crinecerfont SSR-125543		Alkynes
Crinecerfont (SSR-125543) is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency . Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-106203A

Crinecerfont hydrochloride SSR-125543 hydrochloride		Alkynes
Crinecerfont (SSR-125543) hydrochloride is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont hydrochloride blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont hydrochloride improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont hydrochloride can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency . Crinecerfont hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-106203B

(R)-Crinecerfont (R)-SSR-125543		Alkynes
(R)-Crinecerfont is the R-enantiomer of Crinecerfont (HY-106203). Crinecerfont (SSR-125543) is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency . Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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